Current and Recent Projects
The Southern California Center is the natural outcome of more than 20 years of work by RAND and its affiliated institutions in reviewing the biomedical literature for evidence of benefits, harms, and costs; using meta-analysis, decision analysis, and cost-effectiveness analysis to synthesize the literature; developing measures of clinical appropriateness and practice guidelines; developing and assessing medical review criteria; and developing and assessing performance measures and other tools for translating evidence-based knowledge into clinical practice.
Below is a list of EPC projects. Projects marked with an asterisk (*) are currently in progress.
Clinical Care Projects
Aging, Healthy
- Preventive Services for Persons 65 and Older
- Smoking Cessation
- Health Risk Appraisals and Medicare
- Chronic Disease Self-Management
- Falls Prevention
- Exercise and Older Adults
Cancer and Blood Disorders
Complementary and Alternative Medicine
- Ayurvedic Interventions for Diabetes Mellitus
- Mind-Body Interventions for Gastrointestinal Conditions
- S-Adenosyl Methionine (SAM-E) for Treatment of Depression, Osteoarthritis, and Liver Disease
- Complementary and Alternative Therapies for Cancer: A Best Case Series
- Antioxidants for Cancer
- Antioxidants for Cardiovascular Disease
Dietary Supplements
- Antioxidants for Cancer
- Antioxidants for Cardiovascular Disease
- Ephedra: Clinical Efficacy and Side-effects
- Health Benefits of Omega-3 Fatty Acids
- Omega-3 Fatty Acids and Cancer
- Omega-3 Fatty Acids and Type II Diabetes, Immune Disorders, and Renal Disease
- Omega-3 Fatty Acids and Cognitive Functions and Neurological Disorders
- S-Adenosyl Methionine (SAM-E) for Treatment of Depression, Osteoarthritis, and Liver Disease
- Safety of Probiotics Used to Reduce Risk*
Ear, Nose, and Throat Conditions
- Diagnosis and Treatment of Acute Otitis Media - Update
- Management of Acute Otitis Media in Children
- Diagnosis and Treatment of Otitis Media with Effusion
Eye Conditions
Heart and Vascular Diseases
- Diagnosis and Treatment of Heart Failure
- Prevention of Venous Thromboembolism
- Newer Antiplatelet Agents: Evidence for Effectiveness
- Angiotensin II Receptor Antagonists: Evidence for Effectiveness
Infectious Diseases
Kidney Conditions (see also Nerve and Brain Conditions below)
Mental Health
- Autism Intervention Research Networks*
- Efficacy and Comparative Effectiveness of Off-label Use of Atypical Antipsychotics: Update
- Efficacy and Comparative Effectiveness of Off-label Use of Atypical Antipsychotics
- Developing Guidelines for Treatment of Autism in Children
- Anti-epileptic Drugs in Mood Disorders or Pain: Evidence for the Effectiveness
- Off-Label Uses of Atypical Antipsychotic Medications
Metabolic, Nutritional, and Endocrine Conditions
- LapBand for Metabolic Conditions*
- Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low bone Density or Osteoporosis: Update*
- Food Allergy: Evidence Review
- Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low bone Density or Osteoporosis*
- Obesity: Surgical and Pharmacological Treatments
Musculoskeletal Disorders
Nerve and Brain Conditions
- Autism Intervention Research Networks*
- Developing Guidelines for Treatment of Autism in Children
- Prevention and Management of Urinary Tract Infections in Paralyzed Persons
- Anti-epileptic Drugs Used for Mood Disorders or Pain: Evidence for Effectiveness
- Omega-3 Fatty Acids and Cognitive Functions and Neurological Disorders
Obstetric and Gynecological Disorders
Oral and Gastrointestinal Disorders
Pediatric Conditions
Health Care Services Projects
Financing and Economic Incentives
- Identifying, Characterizing, and Evaluating Health Care Efficiency Measures
- Utilization of Medicare Physician Services
Information Technology
- Electronic Health Information Technology Systems
- Updating and Expanding Reviews of Health Information Technology*
Quality Improvement and Patient Safety
- Allocation of Scarce Resources during Mass Casualty Events*
- Closing the Quality Gap*
- Development of an Integrated Toolkit/Resource Guide for Falls Prevention in Hospitals*
- Defining Continuous Quality Improvement (CQI) for Health Care Delivery*
- Critical Analysis of the Evidence for Patient Safety Practices*
- Development of Measures for Medicare Advantage Organizations and Special Needs Plans*
- Validity and Reliability Testing of Quality Assessment Tools*
- Developing Criteria for Context Sensitive Patient Safety Practices*
- Advancing the Science of Continuous Quality Improvement: A Framework for Identifying, Classifying, and Evaluating Continuous Quality Improvement Studies
- Cancer Care Quality Measures: Symptoms and End-of-Life Care
- End-of-Life Care and Outcomes
-
Healthy Aging (see Aging, Healthy above)
- Preventive Services for Persons 65 and Older
- Smoking Cessation
- Health Risk Appraisals and Medicare
- Chronic Disease Self Management
- Falls Prevention
- Exercise and Older Adults
- Identifying, Characterizing, and Evaluating Healthcare Efficiency Measures
- Preventing Violence in Adolescents
Technical Projects
Methodology
- Surveillance and Identification of Triggers for Updating*
- USAID Strength of Evidence*
- Machine Learning Methods in Systematic Reviews*
- Methods and Evaluation of Updating for Systematic Reviews*
- Assessing Empirical Evidence of Association between Internal Validity*
- Identifying Signals for Updating Systematic Reviews*
- Effectiveness Reviews for Medicare Modernization Act
- Reliability of Cochrane Risk of Bias Tool
- Validity of AHRQ Clinical Practice Guidelines
- Meta-regression Approaches
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