Effect of Supplemental Vitamin E for the Prevention and Treatment of Cardiovascular Disease

Published in: Journal of General Internal Medicine, v. 19, no. 4, Apr. 2004, p. 380-389

Posted on RAND.org on January 01, 2004

by Paul G. Shekelle, Sally C. Morton, Lara Hilton, Jay Udani, Myles Spar, Wenli Tu, Marika Booth, Ian D. Coulter, Sydne Newberry, Mary L. Hardy

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OBJECTIVE: To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease. DESIGN: Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified. MEASUREMENTS AND MAIN RESULTS: Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively. CONCLUSIONS: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

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