Journal Article
An Evidence Map of Randomised Controlled Trials Evaluating Genetic Therapies
This evidence map provides a broad overview of the genetic therapies that have been evaluated in randomised controlled trials for efficacy and safety.
2020
Report
Primary Care Productivity: Findings from the Literature and Perspectives from a Stakeholder Panel
To advance understanding of primary care clinic productivity, the authors reviewed relevant literature and convened stakeholders to explore definitions, identify relevant tools, and establish consensus on key aspects of primary care productivity.
Feb 17, 2021
Report
Clinical Interventions for Adults with Comorbid Alcohol Use and Depressive Disorders: A Systematic Review and Network Meta-Analysis
The authors synthesize evidence on the effects and compare the effectiveness of clinical interventions for improving symptoms of adults with co-occurring alcohol use and depressive disorders.
Dec 30, 2020
Journal Article
What Are the Determinants of Health System Performance? Findings from the Literature and a Technical Expert Panel
This study is part of an ongoing effort to discover how and why some health systems in the United States are high performing and others are not.
Jan 28, 2020
Report
Gender Differences in Response to Alcohol Use Disorder Treatment: A Systematic Review
If men and women respond differently to treatments for alcohol use disorder, this would be important to consider in treatment selection. The authors of this systematic review sought to synthesize evidence for gender differences in treatment effects.
Nov 6, 2019
Report
The Use of Technology to Augment Clinical Care in Depression and Anxiety Disorders: An Evidence Map
This evidence map provides an overview of the existing research evaluating technology in depression and anxiety care and documents upcoming research to evaluate the role of technology to support clinical care.
Aug 15, 2019
Journal Article
Obesity Prevention Interventions and Implications for Energy Balance in the United States and Mexico: A Systematic Review of the Evidence and Meta-Analysis
Obesity is preventable and yet continues to be a major risk factor for chronic disease. This review searched the vast literature on obesity prevention interventions to assess their effects on daily energy consumed and energy expended.
Aug 8, 2019
Journal Article
A Systematic Review in Support of the National Consensus Project Clinical Practice Guidelines for Quality Palliative Care, Fourth Edition
A substantial body of evidence exists to support clinical practice guidelines for quality palliative care but the quality of evidence is limited.
2018
Journal Article
Elusive Search for Effective Provider Interventions: A Systematic Review of Provider Interventions to Increase Adherence to Evidence-Based Treatment for Depression
Low quality of evidence and lack of replication of specific intervention strategies across studies limit conclusions that can be drawn from the existing research about the effectiveness of interventions to improve adherence to antidepressant medications.
Dec 20, 2018
Report
Provider Interventions to Increase Uptake of Evidence-Based Treatment for Depression: A Systematic Review
This systematic review synthesizes evidence of health care provider interventions to promote evidence-based treatment of depression across provider groups, care settings, and patient health.
Sep 10, 2018
Journal Article
The Use of Technology in the Clinical Care of Depression: An Evidence Map
This evidence map provides a broad overview of the existing research evaluating technology in depression care. Computer applications are most common. Almost all applications yield symptom improvement. Further research on these applications is needed.
Aug 22, 2018
Journal Article
Describing Care Coordination of Gynecologic Oncology in Western Healthcare Settings: A Rapid Review
This article discusses a rapid review of the literature on characteristics of care coordination for gynecologic malignancies.
Jul 6, 2018
Journal Article
Diagnosis of Celiac Disease
This document summarizes results of a systematic review of tests used to diagnose celiac disease.
2016
Journal Article
Mindfulness-based Relapse Prevention for Substance Use Disorders: A Systematic Review and Meta-analysis
Across studies, our analyses did not indicate that MBRP has beneficial clinical effects beyond comparator interventions (such as relapse prevention, health education, CBT, andTAU) on substance use relapse.
Aug 15, 2017
Journal Article
What Defines a High-Performing Health System: A Systematic Review
Lack of a consistent definition of a high-performing health system severely hampers our ability to compare delivery systems based on performance.
Aug 15, 2017
Journal Article
Machine Learning Versus Standard Techniques for Updating Searches for Systematic Reviews: A Diagnostic Accuracy Study
Machine-learning methods can help decrease the effort involved in updating searches for systematic reviews.
Aug 1, 2017
Journal Article
Acupuncture for the Treatment of Adults with Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis
A systematic review found little support for promoting acupuncture as an evidence-based treatment for post-traumatic stress disorder.
May 30, 2017
Report
Needle Acupuncture for Posttraumatic Stress Disorder (PTSD): A Systematic Review
RAND researchers conducted a systematic review that synthesized evidence from trials of needle acupuncture to provide estimates of its efficacy and safety for treating posttraumatic stress disorder.
Mar 15, 2017
Journal Article
Diagnosis of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline
Various clinical algorithms show promise for providing at least a provisional gout diagnosis in patients who present with signs of early-stage disease; such patients are most likely to be seen in primary, urgent, and emergency care settings.
Nov 30, 2016
Journal Article
Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline
This systematic review found strong evidence for using colchicine, NSAIDs, and corticosteroids to relieve symptoms of acute gout attacks.
Nov 30, 2016
Journal Article
Hyaluronic Acid Injection Therapy for Osteoarthritis of the Knee: Concordant Efficacy and Conflicting Serious Adverse Events in Two Systematic Reviews
A lack of standards for reporting and synthesizing adverse events associated with common treatments can lead to conflicting conclusions about the balance of their benefits and harms.
Nov 28, 2016
Journal Article
Populations and Interventions for Palliative and End-of-Life Care: A Systematic Review
This evidence review found that palliative care improves outcomes for cancer, dementia, congestive heart failure, and chronic obstructive pulmonary disease.
Sep 12, 2016
Journal Article
Surveillance and Identification of Signals for Updating Systematic Reviews: Implementation and Early Experience
The question of how to determine when a systematic review needs to be updated is of considerable importance. Developing and implementing a surveillance process for quickly identifying Comparative Effectiveness Reviews (CERs) in need of updating.
2013
Journal Article
Acupuncture for Substance Use Disorders: A Systematic Review and Meta-Analysis
This systematic review aims to estimate the effects of acupuncture for adults with substance use disorders (SUDs).
Mar 9, 2016
Journal Article
Development of the Quality Improvement Minimum Quality Criteria Set (QI-MQCS): A Tool for Critical Appraisal of Quality Improvement Intervention Publications
Valid, reliable critical appraisal tools advance quality improvement (QI) intervention impacts by helping stakeholders identify higher quality studies.
Dec 23, 2015
Journal Article
The Minimum Quality Criteria Set (QI-MQCS) for Critical Appraisal: Advancing the Science of Quality Improvement
This meeting abstract documents expert panel deliberations intended to develop a critical appraisal instrument to promote identification, dissemination and implementation of findings from high quality improvement initiative evaluations.
Nov 2, 2015
Journal Article
Systematic Review of School-Based Interventions to Prevent Smoking for Girls
The purpose of this review is to study the effect of school-based interventions on smoking prevention for girls.
Sep 25, 2015
Report
Mindfulness-Based Relapse Prevention for Substance Use Disorders: A Systematic Review
RAND researchers conducted a systematic review that synthesized evidence from trials of Mindfulness-Based Relapse Prevention (MBRP) to provide estimates of its efficacy and safety for treating substance use disorders.
Jul 28, 2015
Report
Needle Acupuncture for Substance Use Disorders: A Systematic Review
RAND researchers conducted a systematic review that synthesized evidence from trials of needle acupuncture to provide estimates of its efficacy and safety for treating substance use disorders.
Jul 28, 2015
Journal Article
Usage and Effect of Health Information Exchange: A Systematic Review
Health information exchange (HIE) is increasing in the United States, and it is incentivized by government policies. The authors systematically review and evaluate evidence of the use and effect of HIE on clinical care.
Dec 3, 2014
Journal Article
Assessment of a Method to Detect Signals for Updating Systematic Reviews
Systematic reviews are a cornerstone of evidence-based medicine but are useful only if up-to-date.
Feb 1, 2014
Journal Article
Comparative Effectiveness of Pharmacologic Treatments to Prevent Fractures: An Updated Systematic Review
Osteoporosis is a major contributor to the propensity to fracture among older adults, and various pharmaceuticals are available to treat it.
2014
Journal Article
A Surveillance System to Assess the Need for Updating Systematic Reviews
This report describes the development and initial results of a surveillance system to assess produced by the Agency for Research and Quality (AHRQ) Evidence-based Practice Center (EPC) Program.
Nov 1, 2013
Journal Article
Making Health Care Safer II: An Updated Critical Analysis of the Evidence for Patient Safety Practices
The goal of this project was to conduct a systematic literature review evaluating the evidence for a large number of patient safety practices.
Mar 1, 2013
Journal Article
Making Health Care Safer II: An Updated Critical Analysis of the Evidence for Patient Safety Practices : Executive Summary
The authors review patient safety practices for evidence of effectiveness, implementation, and adoption.
Mar 1, 2013
Journal Article
Incorporating Evidence Review Into Quality Improvement: Meeting the Needs of Innovators
Achieving quality improvement (QI) aims often requires local innovation.
2013
Journal Article
A Pilot Study Using Machine Learning and Domain Knowledge to Facilitate Comparative Effectiveness Review Updating
Comparative effectiveness reviews need to be updated frequently to maintain their relevance.
Sep 1, 2012
Journal Article
A Pilot Study Using Machine Learning and Domain Knowledge to Facilitate Comparative Effectiveness Review Updating
Comparative effectiveness and systematic reviews require frequent and time-consuming updating. Results of earlier screening should be useful in reducing the effort needed to screen relevant articles.
2013
Journal Article
Off-label Use of Atypical Antipsychotics: An Update
The authors performed a systematic review on the efficacy and safety of atypical antipsychotic drugs for use in conditions lacking FDA approval.
Sep 1, 2011
Journal Article
Safety of Probiotics to Reduce Risk and Prevent or Treat Disease
The existing scientific literature does not adequately address questions about the safety of probiotics.
2011