Southern California Evidence-based Practice Center 1997-2019: Projects and Publications

2019

Funding Agency Project Topic Journal Articles and Evidence Reports
Department of Veterans Affairs VA-ESP Program Support 2014

Hilton L, Marshall N, Motala A, Taylor S, Miake-Lye I, Baxi S, Shanman R, Solloway M, Beroes J, Hempel S (in press). Mindfulness Meditation for Workplace Wellness: An Evidence Map. WORK: A Journal of Prevention, Assessment & Rehabilitation.

Hempel S, Taylor SL, Marshall NJ, Miake-Lye IM, Beroes J, Shanman R, Solloway MR, Shekelle PG (2014). Evidence Map of Mindfulness. VA-ESP Project #05-226; 2014. Washington (DC): Department of Veterans Affairs; 2014 Oct. VA Evidence-based Synthesis Program Reports.

Hempel S, Taylor SL, Solloway M, Miake-Lye IM, Beroes JM, Shanman R, Shekelle PG. (2014) Evidence Map of Tai Chi. VA-ESP Project #05-226; 2014. Washington (DC): Department of Veterans Affairs; 2014 Sep. VA Evidence-based Synthesis Program Reports.

USC, AHRQ Interacting with Autism

Interacting with Autism. Last updated January 2019; http://www.interactingwithautism.com

Harris MJ, Kinder M, Shekelle PG, Croen L, Challman T. Partnership for Research & Dissemination of Evidence-Based Medicine in Autism-Final Report. Prepared for the Agency for Healthcare Research and Quality under award number R24 HS022029-01. University of Southern California February 29, 2016.

Gratome. Partnership for Research &Dissemination of Evidence-Based Medicine in Autism. http://grantome.com/grant/NIH/R24-HS022029-01

RAND Corporation. Interacting with Autism: A USC-RAND Partnership. https://www.rand.org/well-being/social-and-behavioral-policy/projects/autism-partnership.html

PCORI Genetic Therapy

Richardson A, Apaydin E, Baxi S, Vockley J, Akinniranye O, Larkin J, Motala A, Hempel S. Landscape Review and Evidence Map of Gene Therapy: Adenovirus, Adeno-associated Virus, and Clustered Regularly Interspaced Short Palindromic Repeats. In: (PCORI) P-CORI (ed.). Patient-Centered Outcomes Research Institute Washington, DC 2019; 175.

Apaydin E, Richardson AS, Vockley G, Baxi SM, Akinniranye O, Larkin J, Motala A, Hempel S. Evidence map of genetic therapy interventions. Accessed March 20, 2019. https://osf.io/8v93h/

Department of Veterans Affairs Quality Improvement Toolkit

Hempel S, Miake-Lye I, Brega AG, Buckhold F, 3rd, Hassell S, Nowalk MP, Rubenstein L, Schreiber K, Spector WD, Kilbourne AM, Ganz DA. Quality Improvement Toolkits: Recommendations for Development. Am J Med Qual. Jan 24 2019:1062860618822102. PMID: 30675797

Psychological Health Center of Excellence Systematic Reviews of Psychological Health Research to Address Gaps in Practice II

Vaughan C, Azhar G, Chen C, Akinniranye O, Zutshi R, Ramchand R, Motala A, Larkin J, Hempel S. Interventions for people who have attempted suicide and their family members: a systematic review PROSPERO 2018 CRD42018116997.

Maher AR, Apaydin E, Troxel W, Larkin J, Azhar G, Motala A, Hempel S, Hilton L. Sleep management in posttraumatic stress disorder (PTSD): a systematic review. PROSPERO 2018 CRD42018102200.

Maglione M, Chen C, Baxi S, Shahidinia N, Tebeka M, Franco M, Motala A, S. H. Predictors of PTSD treatment, retention and response. PROSPERO 2018 CRD42018115995.

2018

Funding Agency Project Topic Journal Articles and Evidence Reports
National Coalition for Hospice and Palliative Care NCP Clinical Practice Guidelines for Quality Palliative Care Systematic Review

Ahluwalia SC, Chen C, Raaen L, Motala A, Walling AM, Chamberlin M, O'Hanlon C, Larkin J, Lorenz K, Akinniranye O, Hempel S. A Systematic Review in Support of the National Consensus Project Clinical Practice Guidelines for Quality Palliative Care, Fourth Edition. J Pain Symptom Manage. Dec 2018;56(6):831-870. PMID: 30391049

Ahluwalia S, Cohen C, Chamberlin M, Chen C, Hempel S, Motala A, Larkin J, O'Hanlon C, Raaen L, A. W. National consensus project clinical practice guidelines for quality palliative care systematic review, fourth edition. PROSPERO 2018 CRD42018100065.

RAND Corporation. Press Release: Best Practices in Providing Palliative Care Supported by Growing Body of Evidence.

USC, AHRQ Understanding and Modeling Innovation in Alzheimer's Disease

Shekelle PG, Goldman DP. Development of a Group Judgment Process for Forecasts of Health Care Innovations. JAMA Netw Open. Nov 2 2018;1(7):e185108. PMID: 30646380.

Department of Veterans Affairs VA-ESP Program Support 2015

MacQueen IT, Maggard-Gibbons M, Capra G, Raaen L, Ulloa JG, Shekelle PG, Miake-Lye I, Beroes JM, Hempel S. Recruiting Rural Healthcare Providers Today: a Systematic Review of Training Program Success and Determinants of Geographic Choices. J Gen Intern Med. Feb 2018;33(2):191-199. PMID: 29181791.

Hempel, S, Maggard, M, Ulloa, J, Macqueen, I, Miake-Lye, I, Beroes, J, Shanman, R, Shekelle. P. Rural healthcare: a systematic review. PROSPERO 2015 CRD42015025403. Feb 2018;33(2):191-199. PMID: 29181791.

Hempel S, Graham G, Fu N, Estrada E, Chen A, Miake-Lye, Miles J, Shanman R, Shekelle P, Beroes J, Wallin M (2017). A systematic review of the effects of modifiable risk factor interventions on the progression of multiple sclerosis. Multiple Sclerosis Journal. Feb 1:1352458517690271. doi: 10.1177/1352458517690271.

Hempel S, Graham G, Fu N, Estrada E, Chen A, Miake-Lye I, Miles J, Shanman R, Shekelle P, Beroes J, Wallin M (2017). A systematic review of modifiable risk factors in the progression of multiple sclerosis. Multiple Sclerosis Journal. Feb 1:1352458517690270. doi: 10.1177/1352458517690270.

Hempel S, Maggard Gibbons M, Ulloa JG, Macqueen I, Miake-Lye I, Beroes J, Shekelle P (2015). Rural Healthcare Workforce: A Systematic Review. VA ESP Project #05-226; 2015. Washington (DC): Department of Veterans Affairs; 2014 Oct. VA Evidence-based Synthesis Program Reports.

Hempel S, Fu, N, Estrada E, Chen A, Miake-Lye I, Beroes J, Miles JNV, Shanman R, Shekelle P (2015). Risk Factors for Multiple Sclerosis Progression: A Systematic Review. VA ESP Project #05-226; 2015. Washington (DC): Department of Veterans Affairs; 2014 Oct. VA Evidence-based Synthesis Program Reports.

Hempel, S. Estrada, E, Chen, A, Miake-Lye, I, Beroes, J, Shanman, R, Shekelle. P. Modifiable risk factors in the progression of multiple sclerosis. J Gen Intern Med. Feb 2018;33(2):191-199. PMID: 29181791.

Maggard Gibbons M A, Maher A M, Dawes A J, Booth M S, MiakeLye I M, Beroes J M, Shekelle P G. Psychological Clearance for Bariatric Surgery: A Systematic Review. VA-ESP Project #05-226; 2014.

Dawes AJ, Maggard-Gibbons M, Maher AR, Booth MJ, Miake-Lye I, Beroes JM, Shekelle PG. Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis. JAMA Jan 12 2016;315(2):150-163. PMID: 26757464.

Department of Veterans Affairs Access management

Hempel, S, Stockdale S, Danz M, Rose D, Kirsh S, Curtis I, Rubenstein L. Access Management in Primary Care: Perspectives from an Expert Panel. Santa Monica, CA 2018.

Psychological Health Center of Excellence Systematic Reviews of Psychological Health Research to Address Gaps in Practice I

Maglione MA, Raaen L, Chen C, Azhar G, Shahidinia N, Shen M, Maksabedian E, Shanman RM, Newberry S, Hempel S. Effects of medication assisted treatment (MAT) for opioid use disorder on functional outcomes: A systematic review. J Subst Abuse Treat. Jun 2018;89:28-51. PMID: 29706172.

Maglione M, Raaen L, Chen C, Azhar G, Shahidinia N, Shen M, Maksabedian E, Shanman R, Hempel S. Effects of Medication-Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes: A Systematic Review. Santa Monica, CA 2018.

Maglione M, Hempel S, Newberry S, Maher AR, Colaiaco B, Kandrack R, Ewing B, Shanman R, Sorbero M. Mindfulness meditation for tobacco use cessation. PROSPERO 2015 CRD42015025053.

Pedersen ER, Rubenstein L, Kandrack R, Danz M, Belsher B, Motala A, Booth M, Larkin J, Hempel S. Elusive search for effective provider interventions: a systematic review of provider interventions to increase adherence to evidence-based treatment for depression. Implement Sci. Jul 20 2018;13(1):99. PMID: 30029676

Pedersen E, Kandrack R, Danz M, Motala A, Booth M, Larkin J, Hempel S. Provider Interventions to Increase Uptake of Evidence-Based Treatment for Depression: A Systematic Review. Santa Monica, CA 2018.

Pedersen E, Kandrack R, Danz M, Motala A, Booth M, Larkin J, Hempel S. Provider interventions to increase uptake of evidence-based treatment for depression. ID=CRD42017060460.

Apaydin E, Maher AR, Raaen L, Motala A, Baxi S, Shanman R, and Hempel S (2018). The use of technology in the clinical care in depression: an evidence map. Journal of Clinical Psychiatry, Aug 21 2018;79(5). PMID: 30152646. https://www.ncbi.nlm.nih.gov/pubmed/30152646.

Maher AR, Hempel S, Apaydin E. The use of technology to augment clinical care in depression and anxiety disorders. PROSPERO 2017 CRD42017069691.

Grant S, Larkin J, Booth M, Azhar G, Han E, Motala A, Hempel S. Interventions for adults with co-morbid alcohol use and depressive disorders: a systematic review and network meta-analysis protocol. PROSPERO 2017 CRD42017078239.

Newberry S, Rutter C, Hempel S. Gender differences in response to alcohol use disorder treatment. PROSPERO 2017 CRD42017070895.

AHRQ EPC Program Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks

Newberry SJ, Chung M, Anderson CAM, Chen C, Fu Z, Tang A, Zhao N, Booth M, Marks J, Hollands S, Motala A, Larkin JK, Shanman R, Hempel S. Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks. Comparative Effectiveness Review No. 206. (Prepared by the RAND Southern California Evidence-based Practice Center under Contract No. 290-2015-00010-I.) AHRQ Publication No. 18-EHC009-EF. Rockville, MD: Agency for Healthcare Research and Quality; June 2018. Posted final reports are located on the Effective Health Care Program search page. DOI: https://doi.org/10.23970/AHRQEPCCER206.

Newberry S, Hempel S, Chung M, Tang A, Anderson C, Fu Z, Zhao N, Motala A, Booth M, Marks J, Shanman R, Hollands S, Chen C, Smith P, M. T. Effects of dietary sodium and potassium intake on chronic disease outcomes and related risk factors. PROSPERO 2017 CRD42017056126

AHRQ EPC Program TO1 FY18 Methods and Dissemination

Chou R, Baker WL, Banez LL, Iyer S, Myers ER, Newberry S, Pincock L, Robinson KA, Sardenga L, Sathe N, Springs S, Wilt TJ. Agency for Healthcare Research and Quality Evidence-based Practice Center methods provide guidance on prioritization and selection of harms in systematic reviews. J Clin Epidemiol. Jun 2018;98:98-104. PMID: 29409913

Yepes-Nunez JJ, Morgan RL, Mbuagbaw L, Carrasco-Labra A, Chang S, Hempel S, Shekelle P, Helfand M, Baldeh T, Schunemann HJ. Two alternatives versus the standard Grading of Recommendations Assessment, Development and Evaluation (GRADE) summary of findings (SoF) tables to improve understanding in the presentation of systematic review results: a three-arm, randomised, controlled, non-inferiority trial. BMJ Open. Jan 23 2018;8(1):e015623. PMID: 29362242

Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L, Hempel S, Akl EA, Chang C, McGowan J, Stewart L, Hartling L, Aldcroft A, Wilson MG, Garritty C, Lewin S, Godfrey CM, Macdonald MT, Langlois EV, Soares-Weiser K, Moriarty J, Clifford T, Tuncalp O, Straus SE. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. Oct 2 2018;169(7):467-473. PMID: 30178033

Mitchell MD, White CM, Guise J-M, Bañez L, Umscheid C, Hartling L, Lyer S, Borsky A, Berkman N, Robinson K, Newberry S, Fiordalisi C, Henderson J, Sandlers-Schmidler G. How Do Health System Leaders Use Evidence To Inform Action? International Journal of Technology Assessment in Health Care. 2018;34(S1):74-75. doi:10.1017/S0266462318001940

Lin JS, Rubenstein LV, Beil TL, Hempel S. Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test of an Interactive, Web-Based Presentation and Discussion of Evidence. Rockville (MD); 2018.

2017

Funding Agency Project Topic Journal Articles and Evidence Reports
NIH Child Health and Human Development Microsimulation of Obesity Policies

Hempel S, Richardson A, Sturm R, Raaen L, Motala A, Azhar G. Systematic review protocol for obesity prevention policies. CRD42017077083. Available at: http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017077083

Department of Veterans Affairs VA-ESP Program Support 2015

MacQueen IT, Maggard-Gibbons M, Capra G, Raaen L, Ulloa JG, Shekelle PG, Miake-Lye I, Beroes JM, Hempel S. Recruiting Rural Healthcare Providers Today: a Systematic Review of Training Program Success and Determinants of Geographic Choices. J Gen Intern Med. Feb 2018;33(2):191-199. PMID: 29181791

Hempel, S, Maggard, M, Ulloa, J, Macqueen, I, Miake-Lye, I, Beroes, J, Shanman, R, Shekelle. P. Rural healthcare: a systematic review. PROSPERO. 2015 CRD42015025403

Hempel S, Graham G, Fu N, Estrada E, Chen A, Miake-Lye, Miles J, Shanman R, Shekelle P, Beroes J, Wallin M (2017). A systematic review of the effects of modifiable risk factor interventions on the progression of multiple sclerosis. Multiple Sclerosis Journal, Feb 1:1352458517690271. doi: 10.1177/1352458517690271.

Hempel S, Graham G, Fu N, Estrada E, Chen A, Miake-Lye I, Miles J, Shanman R, Shekelle P, Beroes J, Wallin M (2017). A systematic review of modifiable risk factors in the progression of multiple sclerosis. Multiple Sclerosis Journal, Feb 1:1352458517690270. doi: 10.1177/1352458517690270.

Hempel S, Maggard Gibbons M, Ulloa JG, Macqueen I, Miake-Lye I, Beroes J, Shekelle P (2015). Rural Healthcare Workforce: A Systematic Review. VA-ESP Project #05-226; 2015. Washington (DC): Department of Veterans Affairs; 2014 Oct. VA Evidence-based Synthesis Program Reports.

Hempel S, Fu, N, Estrada E, Chen A, Miake-Lye I, Beroes J, Miles JNV, Shanman R, Shekelle P (2015). Risk Factors for Multiple Sclerosis Progression: A Systematic Review. VA-ESP Project #05-226; 2015. Washington (DC): Department of Veterans Affairs; 2014 Oct. VA Evidence-based Synthesis Program Reports.

Hempel, S. Estrada, E, Chen, A, Miake-Lye, I, Beroes, J, Shanman, R, Shekelle. P. Modifiable risk factors in the progression of multiple sclerosis.. PROSPERO. J2015 CRD42015016461

Maggard Gibbons M A, Maher A M, Dawes A J, Booth M S, MiakeLye I M, Beroes J M, Shekelle P G. Psychological Clearance for Bariatric Surgery: A Systematic Review. VA-ESP Project #05-226; 2014.

Dawes AJ, Maggard-Gibbons M, Maher AR, Booth MJ, Miake-Lye I, Beroes JM, Shekelle PG. Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis. JAMA. Jan 12 2016;315(2):150-163. PMID: 26757464

Defense Centers of Excellence for Psychological Health and Traumatic Injury Evaluation of efficacy and comparative effectiveness of integrative medicine approaches to the prevention and treatment of psychological health conditions and traumatic brain injury in the Department of Defense

Grant S, Colaiaco B, Motala A, Shanman R, Booth M, Sorbero M, Hempel S (2017). Mindfulness-Based Relapse Prevention for Substance Use Disorders: A Systematic Review and Meta-Analysis. Journal of Addiction Medicine, Jul 19, doi: 10.1097/ADM.0000000000000338. [Epub ahead of print].

Grant S, Hempel S, Colaiaco B, Motala A, Shanman R, Booth M, Dudley W, Smith P, Sorbero M (2015). Mindfulness-Based Relapse Prevention (MBRP) for Substance Use Disorders: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

Maglione M, Ruelaz Maher A, Ewing B, Colaiaco B, Newberry S, Kandrack R, Shanman R, Sorbero M, Hempel S (2017). Efficacy of mindfulness meditation for smoking cessation: A systematic review and meta-analysis. Addictive Behaviors 69 (2017) 27–34.

Maglione M, Hempel S, Ruelaz Maher A, Ewing B, Colaiaco B, Newberry S, Kandrack R, Shanman R, Sorbero M. (2016). Mindfulness Meditation for the Treatment of Tobacco Use: A Systematic Review. Santa Monica, CA: RAND Corporation, 2016.

Maglione, Margaret A., Susanne Hempel, Alicia Ruelaz Maher, Eric Apaydin, Brett Ewing, Lara Hilton, Lea Xenakis, Roberta M. Shanman, Sydne Newberry, Benjamin Colaiaco and Melony E. Sorbero. Mindfulness Meditation for Chronic Pain: A Systematic Review. Santa Monica, CA: RAND Corporation, 2016.

Hilton L, Hempel S, Ewing BA, Apaydin E, Xenakis L, Newberry S, Colaiaco B, Maher AR, Shanman RM, Sorbero ME, Maglione MA. Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis. Ann Behav Med. Sep 22 2016. PMID: 27658913

Newberry S, Hempel S, Booth M, Ewing B, Maher A, O’Hanlon C, Sloan J, Vaughan C, Dudley W, Shanman R, Sorbero M (2015). Omega-3 Fatty Acids for Major Depressive Disorder: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

Maher A, Hempel S, Apaydin E, Shanman R, Booth M, Miles J, Sorbero M (2015). St. John's Wort for Major Depressive Disorder: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

Apaydin EA, Maher AR, Shanman R, Booth MS, Miles JN, Sorbero ME, Hempel S. A systematic review of St. John's wort for major depressive disorder. Syst Rev. Sep 02 2016;5(1):148. PMID: 27589952

Grant S, Hempel S, Kandrack R, Motala A, Shanman R, Booth M, Miles J, Dudley W, Smith P, Sorbero M (2015). Needle Acupuncture for Substance Use Disorders: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

Grant S, Kandrack R, Motala A, Shanman R, Booth M, Miles J, Sorbero M, Hempel S. Acupuncture for substance use disorders: A systematic review and meta-analysis. Drug Alcohol Depend. Jun 01 2016;163:1-15. PMID: 26968093

Defense Centers of Excellence for Psychological Health and Traumatic Injury Extent, effectiveness and cost-effectiveness of integrative medicine approaches to the prevention and treatment of psychological health conditions and traumatic brain injury in the Department of Defense

Grant S, Colaiaco B, Motala A, Shanman R, Sorbero M, Hempel S. (2017). Needle Acupuncture for Posttraumatic Stress Disorder (PTSD): A Systematic Review. Santa Monica, CA: RAND Corporation, 2017.

Grant S, Colaiaco B, Motala A, Shanman R, Sorbero M, Hempel S (2017). Acupuncture for the Treatment of Adults with Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis. Journal of Trauma & Dissociation, doi:10.1080/15299732.2017.1289493.

Hilton L, Ruelaz Ruelaz A, Colaiaco B, Apaydin E, Sorbero M, Booth M, Shanman R, Hempel S. (2017). Meditation for Posttraumatic Stress Disorder: A Systematic Review. Santa Monica, CA: RAND Corporation, 2017.

Hilton L, Maher AR, Colaiaco B, Apaydin E, Sorbero ME, Booth M, Shanman RM, Hempel S. Meditation for Posttraumatic Stress: Systematic Review and Meta-analysis. Psychol Trauma. Aug 18 2016. PMID: 27537781

Hilton L, Sorbero M, Maher A, Shanman R, Hempel S. Meditation for Posttraumatic Stress Disorder (PTSD). PROSPERO 2015 CRD42015025782.

Melony E. Sorbero, Kerry A. Reynolds, Coreen Farris, Ben Colaiaco, Susan L. Lovejoy, Christine Vaughan, Jennifer Sloan, Ryan Kandrack, Eric Apaydin and Patricia Herman, Acupuncture for Major Depressive Disorder: A Systematic Review, RR-1135-OSD, 2015.

Sorbero M, Ahluwalia S, Reynolds K, Lovejoy S, Farris C, Sloan J, Miles J, Vaughan C, Kandrack R, Apaydin E, Colaiaco B, Herman P (2015). Meditation for Depression: A Systematic Review of Mindfulness-Based Cognitive Therapy for Major Depressive Disorder. Santa Monica, CA: RAND Corporation, 2015.

National Institute for Occupational Safety and Health (NIOSH) Systematic Review Guidance Document for Occupational Safety and Health Outcomes

Hempel, Susanne, Lea Xenakis and Marjorie Danz. Systematic Reviews for Occupational Safety and Health Questions: Resources for Evidence Synthesis. Santa Monica, CA: RAND Corporation, 2016.

AHRQ EPC Program Treatment of Osteoarthritis of the Knee: An Update Review

Newberry SJ, FitzGerald J, SooHoo NF, Booth M, Marks J, Motala A, Apaydin E, Chen C, Raaen L, Shanman R, Shekelle PG. Treatment of Osteoarthritis of the Knee: An Update Review. Comparative Effectiveness Review No. 190. (Prepared by the RAND Southern California Evidence-based Practice Center under Contract No. 290-2015-00010-I.) AHRQ Publication No.17-EHC011-EF. Rockville, MD: Agency for Healthcare Research and Quality; May 2017. DOI: https://doi.org/10.23970/AHRQEPCCER190. https://www.ncbi.nlm.nih.gov/pubmed/28825779

AHRQ EPC Program TO1 FY17 Methods and Dissemination

White CM, Sanders Schmidler GD, Butler M, Wang Z, Robinson K, Mitchell MD, Berkman N, Henderson J, Fiordalisi C, Hartling L, Newberry SJ, Guise JM, Borsky A, Niebuhr D, Pham D, Gozu A, Iyer S, Banez L. Understanding Health-Systems' Use of and Need for Evidence To Inform Decisionmaking. Rockville (MD); 2017.

Morton SC, Murad MH, O’Connor E, Lee CS, Booth M, Vandermeer BW, Snowden JM, D’Anci KE, Fu R, Gartlehner G, Wang Z, Steele DW. Quantitative Synthesis—An Update. Methods Guide for Comparative Effectiveness Reviews. (Prepared by the Scientific Resource Center under Contract No. 290-2012-0004-C). AHRQ Publication No. 18-EHC007-EF. Rockville, MD: Agency for Healthcare Research and Quality; February 2018. Posted final reports are located on the Effective Health Care Program search page.

2016

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC Program Methods and Dissemination

Butler M, Epstein R, Totten A, Whitlock E, Ansari M, Damschroder L, Balk E, Bass E, Berkman N, Hempel S, Iyer S, Schoelles K, Guise JM (2017). AHRQ series on complex intervention systematic reviews—paper 3: adapting frameworks to develop protocols. Journal of Clinical Epidemiology, Jun 27. pii: S0895-4356(17)30632-7. doi: 10.1016/j.jclinepi.2017.06.013. [Epub ahead of print]

Hartling L, Guise J-M, Hempel S Featherstone R, Mitchell M, Motu'apuaka M, Robinson K; Schoelles K, Totten A, Whitlock E, Wilt T, Anderson J, Berliner E, Gozu A, Kato E, Paynter E, Umscheid C (2017). Fit for Purpose: perspectives on rapid reviews from end-user interviews. Syst Rev. 2017 Feb 17;6(1):32. doi: 10.1186/s13643-017-0425-7.

Hartling L, Guise JM, Hempel S, Featherstone R, Mitchell MD, Motu'apuaka ML, Robinson KA, Schoelles K, Totten A, Whitlock E, Wilt T, Anderson J, Berliner E, Gozu A, Kato E, Paynter R, Umscheid CA. EPC Methods: AHRQ End User Perspectives of Rapid Reviews. Research White Paper. (Prepared by the Scientific Resource Center under Contract No. 290-2012-00004-C.) AHRQ Publication No.16-EHC014-EF. Rockville, MD: Agency for Healthcare Research and Quality; April 2016.

McPheeters M, Butler M, Maglione M, Viswanathan M, O'Neil M, Epstein R, Anderson J, Guise JM, Gozu A, Kondo K, Chang C. Challenges in Conducting EPC Reviews of Behavior Change Interventions. Rockville (MD); 2015.

Robinson KA, Chou R, Berkman ND, Newberry SJ, Fu R, Hartling L, Dryden D, Butler M, Foisy M, Anderson J, Motu'apuaka M, Relevo R, Guise JM, Chang S. Integrating Bodies of Evidence: Existing Systematic Reviews and Primary Studies. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Rockville (MD); 2008.

Robinson KA, Chou R, Berkman ND, Newberry SJ, Fu R, Hartling L, Dryden D, Butler M, Foisy M, Anderson J, Motu'apuaka M, Relevo R, Guise JM, Chang S. Twelve recommendations for integrating existing systematic reviews into new reviews: EPC guidance. J Clin Epidemiol. Aug 7 2015. PMID: 26261004

Robinson KA, Whitlock EP, O'Neil ME, Anderson JK, Hartling L, Dryden DM, Butler M, Newberry SJ, McPheeters M, Berkman ND, Lin JS, Chang S. Integration of Existing Systematic Reviews. Rockville (MD); 2014.

Robinson KA, Whitlock EP, Oneil ME, Anderson JK, Hartling L, Dryden DM, Butler M, Newberry SJ, McPheeters M, Berkman ND, Lin JS, Chang S. Integration of existing systematic reviews into new reviews: identification of guidance needs. Syst Rev. 2014;3:60. PMID: 24956937

Viswanathan M, Carey TS, Belinson SE, Berliner E, Chang S, Graham E, Guise JM, Ip SS, Maglione MA, McCrory D, McPheeters M, Newberry SJ, Sista P, White CM. Identifying and Managing Nonfinancial Conflicts of Interest for Systematic Reviews. Rockville (MD); 2013.

Viswanathan M, Carey TS, Belinson SE, Berliner E, Chang SM, Graham E, Guise JM, Ip S, Maglione MA, McCrory DC, McPheeters M, Newberry SJ, Sista P, White CM. A proposed approach may help systematic reviews retain needed expertise while minimizing bias from nonfinancial conflicts of interest. J Clin Epidemiol. Nov 2014;67(11):1229-1238. PMID: 25022723 http://www.ncbi.nlm.nih.gov/pubmed/25022723

Hartling, L., Hamm, M., Milne, A., Vandermeer, B., Santaguida, P.L., Ansari, M., Tsertsvadze, A., Hempel, S., Shekelle, P., Dryden, D.M. (2012). Validity and inter-rater reliability testing of quality assessment instruments. (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021-I.) AHRQ Publication No. 12-EHC039-EF. Rockville, MD: Agency for Healthcare Research and Quality. March 2012.

Hartling L, Hamm MP, Milne A, Vandermeer B, Santaguida PL, Ansari M, Tsertsvadze A, Hempel S, Shekelle P, Dryden DM (2012). Testing the Risk of Bias tool showed low reliability between individual reviewers and across consensus assessments of reviewer pairs. J Clin Epidemiol.

AHRQ When are Quality Improvement Interventions Cost Saving, Cost Effective, or Not a Good Value?

Nuckols TK, Keeler E, Anderson LJ, Green J, Morton SC, Doyle BJ, Shetty K, Arifkhanova A, Booth M, Shanman R, Shekelle P. Economic Evaluation of Quality Improvement Interventions Designed to Improve Glycemic Control in Diabetes: A Systematic Review and Weighted Regression Analysis. Diabetes Care. May 2018;41(5):985-993. PMID: 29678865

Anderson LJ, Shekelle P, Keeler E, Uscher-Pines L, Shanman R, Morton S, Aliyev G, Nuckols TK. The Cost of Interventions to Increase Influenza Vaccination: A Systematic Review. Am J Prev Med. Feb 2018;54(2):299-315. PMID: 29362167

Nuckols TK, Keeler E, Morton S, Anderson L, Doyle BJ, Pevnick J, Booth M, Shanman R, Arifkhanova A, Shekelle P. Economic Evaluation of Quality Improvement Interventions Designed to Prevent Hospital Readmission: A Systematic Review and Meta-analysis. JAMA Intern Med. Jul 1 2017;177(7):975-985. PMID: 28558095

Nuckols TK, Keeler E, Morton SC, Anderson L, Doyle B, Booth M, Shanman R, Grein J, Shekelle P. Economic Evaluation of Quality Improvement Interventions for Bloodstream Infections Related to Central Catheters: A Systematic Review. JAMA Intern Med. Oct 24 2016. PMID: 27775764 https://www.ncbi.nlm.nih.gov/pubmed/27775764

AHRQ EPC Program Patient Safety in Ambulatory Settings Shekelle, PG, Sarkar U, Shojania K, Wachter RM, McDonald K, Motala A, Smith P, Zipperer L, Shanman R. Patient Safety in Ambulatory Settings. Technical Brief No. 27. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2015-00010-I.) AHRQ Publication No. 16(17)-EHC033-EF. Rockville, MD: Agency for Healthcare Research and Quality; October 2016.
AHRQ EPC Program Management of Gout

Shekelle, PG. FitzGerald J, Newberry SJ, Motala, A, O'Hanlon CE, Okunogbe, A, Tariq, A, Han, D, Dudley, W, Shanman, R. and Booth M. Management of Gout. Comparative Effectiveness Review No. 176. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2012-00006-I.) AHRQ Publication No. 16-EHC017-EF. Rockville, MD: Agency for Healthcare Research and Quality; March 2016.

Shekelle PG, Newberry SJ, FitzGerald JD, Motala A, O'Hanlon CE, Tariq A, Okunogbe A, Han D, Shanman R. Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline. Ann Intern Med. Jan 03 2017;166(1):37-51. PMID: 27802478

AHRQ EPC Program Diagnosis of Gout

Newberry SJ, FitzGerald J, Maglione MA, O'Hanlon CE, Han D, Booth M, Motala A, Tariq A, Dudley W, Shanman R, Shekelle PG. Diagnosis of Gout. Comparative Effectiveness Review No. 158. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2012-00006-I.) AHRQ Publication No. 15-EHC026-EF. Rockville, MD: Agency for Healthcare Research and Quality; February 2016.

Newberry SJ, FitzGerald JD, Motala A, Booth M, Maglione MA, Han D, Tariq A, O'Hanlon CE, Shanman R, Dudley W, Shekelle PG. Diagnosis of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline. Ann Intern Med. Jan 03 2017;166(1):27-36. PMID: 27802505 https://www.ncbi.nlm.nih.gov/pubmed/27802505

AHRQ EPC Program Diagnosis of Celiac Disease Maglione MA, Okunogbe A, Ewing B, Grant S, Newberry SJ, Motala A, Shanman R, Mejia-Gonzalez N, Arifkhanova A, Shekelle P, Harmon G. Diagnosis of Celiac Disease. Comparative Effectiveness Review No. 162. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2012-00006-I.) AHRQ Publication No. 15-EHC032-EF. Rockville, MD: Agency for Healthcare Research and Quality. January 2016.

2015

Funding Agency Project Topic Journal Articles and Evidence Reports
Department of Veterans Affairs VA Literature Review

Hempel S, Maggard-Gibbons M, Nguyen DK, Dawes AJ, Miake-Lye I, Beroes JM, Booth MJ, Miles JN, Shanman R, Shekelle PG. (2015). Prevention of Wrong Site Surgery, Retained Surgical Items, and Surgical Fires: A Systematic Review. VA-ESP Project #05-226; 2014. Washington (DC): Department of Veterans Affairs; 2014 Jan. VA Evidence-based Synthesis Program Reports.

Hempel S, Maggard-Gibbons M, Nguyen DK, Dawes AJ, Miake-Lye I, Beroes JM, Booth MJ, Miles JN, Shanman R, Shekelle PG. Wrong-Site Surgery, Retained Surgical Items, and Surgical Fires : A Systematic Review of Surgical Never Events. JAMA Surg. Aug 2015;150(8):796-805. PMID: 26061125

Hempel S, Taylor SL, Solloway MR, Miake-Lye IM, Beroes JM, Shanman R, Booth MJ, Siroka AM, Shekelle PG. (2014). Evidence Map of Acupuncture. VA-ESP Project #05-226; 2014. Washington (DC): Department of Veterans Affairs; 2014 Jan. VA Evidence-based Synthesis Program Reports. http://www.hsrd.research.va.gov/publications/management_briefs/default.cfm?ManagementBriefsMenu=eBrief-no78

Taylor S, Hempel S, Solloway M, Miake-Lye I, Beroes J, Shekelle P (2014). An evidence map of the effects of acupuncture. J Altern Complement Med, 20(5): A91-2.

Defense Centers of Excellence for Psychological Health and Traumatic Injury Evaluation of efficacy and comparative effectiveness of integrative medicine approaches to the prevention and treatment of psychological health conditions and traumatic brain injury in the Department of Defense

Newberry S, Hempel S, Booth M, Ewing B, Maher A, O'Hanlon C, Sloan J, Vaughan C, Dudley W, Shanman R, Sorbero M (2015). Omega-3 Fatty Acids for Major Depressive Disorder: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

Maher A, Hempel S, Apaydin E, Shanman R, Booth M, Miles J, Sorbero M (2015). St. John's Wort for Major Depressive Disorder: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

Grant S, Larkin J, Booth M, Azhar G, Han E, Motala A, Hempel S. Interventions for adults with co-morbid alcohol use and depressive disorders: a systematic review and network meta-analysis protocol PROSPERO 2017 CRD42017078239 .

Grant S, Hempel S, Kandrack R, Motala A, Shanman R, Booth M, Miles J, Dudley W, Smith P, Sorbero M (2015). Needle Acupuncture for Substance Use Disorders: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

Grant S, Kandrack R, Motala A, Shanman R, Booth M, Miles J, Sorbero M, Hempel S. Acupuncture for substance use disorders: A systematic review and meta-analysis. Drug Alcohol Depend. Jun 1 2016;163:1-15. PMID: 26968093

Grant S, Hempel S, Colaiaco B, Motala A, Shanman R, Booth M, Dudley W, Smith P, Sorbero M (2015). Mindfulness-Based Relapse Prevention (MBRP) for Substance Use Disorders: A Systematic Review. Santa Monica, CA: RAND Corporation, 2015.

AHRQ EPC Program Systematic Review for Effectiveness of Hyaluronic Acid in the Treatment of Severe Degenerative Joint Disease (DJD) of the Knee

Newberry, SJ, FitzGerald, J., Maglione, M.A., O'Hanlon, C.E., Booth, M., Motala, A., Timmer, M., Shanman, R., Shekelle, P.G., Systematic Review for Effectiveness of Hyaluronic Acid in the Treatment of Severe Degenerative Joint Disease (DJD) of the Knee. Technology Assessment Report No. DJDTO913. (Prepared by the Southern California Evidence-based Practice Center under Contract No. HHSA290201200006I.) Rockville, MD: Agency for Healthcare Research and Quality. July 23, 2015

O'Hanlon CE, Newberry SJ, Booth M, Grant S, Motala A, Maglione MA, FitzGerald JD, Shekelle PG. Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. Syst Rev. Nov 04 2016;5(1):186. PMID: 27814744 https://www.ncbi.nlm.nih.gov/pubmed/27814744

Department of Veterans Affairs Systematic review of school-based interventions to prevent smoking for girls de Kleijn MJ, Farmer MM, Booth M, Motala A, Smith A, Sherman S, Assendelft WJ, Shekelle P. Systematic review of school-based interventions to prevent smoking for girls. Syst Rev. 2015;4:109. PMID: 26272326
RAND, Department of Veterans Affairs, RWJ, and AHRQ Advancing the Science of Quality Improvement

Hempel S, Shekelle PG, Liu JL, Sherwood Danz M, Foy R, Lim YW, Motala A, Rubenstein LV. Development of the Quality Improvement Minimum Quality Criteria Set (QI-MQCS): a tool for critical appraisal of quality improvement intervention publications. BMJ Qual Saf. Dec 2015;24(12):796-804. PMID: 26311020

Rubenstein L, Hempel S, Liu J, Danz M, Foy R, Lim YW, Motala A, Shekelle P. (2015). The Minimum Quality Criteria Set (QI-MQCS) for Critical Appraisal: Advancing the Science of Quality Improvement. Implementation Science, suppl. 1, Aug. 2015, p. A19

Rubenstein, L., Danz, M., Hempel, S., Foy, R. & Shekelle, P.G. (2010). Advancing the science of continuous quality improvement: A framework for identifying, classifying and evaluating continuous quality improvement studies. Final project report. June 2010.

Danz MS, Rubenstein LV, Hempel S, Foy R, Suttorp M, Farmer MM, Shekelle PG. Identifying quality improvement intervention evaluations: is consensus achievable? Qual Saf Health Care. Aug 2010;19(4):279-283.

Rubenstein, L.V., Hempel, S., Farmer, M., Asch, S., Yano, E., Dougherty, D. & Shekelle, P. (2008). Finding order in heterogeneity: Types of quality improvement intervention publications. Quality and Safety in Healthcare, 17(6), 403-8.

Rubenstein, L. Hempel, S., Danz, M., Foy, R., & Shekelle, P. Final Progress Report Expert Panel Meeting Advancing the Science of Continuous Quality Improvement. Grant Award Number: 1R13HS018139-01. Prepared for AHRQ, May 2011.

O'Neill SM, Hempel S, Lim YW, Danz MS, Foy R, Suttorp MJ, Shekelle PG, Rubenstein LV. Identifying continuous quality improvement publications: what makes an improvement intervention 'CQI'? BMJ Qual Saf. Dec 2011;20(12):1011-1019.

Hempel S, Rubenstein LV, Shanman RM, Foy R, Golder S, Danz M, Shekelle PG. Identifying quality improvement intervention publications - A comparison of electronic search strategies. Implement Sci. 2011;6:85.

Department of Veterans Affairs VA Literature Review

Hempel S, Maggard-Gibbons M, Nguyen DK, Dawes AJ, Miake-Lye I, Beroes JM, Booth MJ, Miles JN, Shanman R, Shekelle PG. (2015). Prevention of Wrong Site Surgery, Retained Surgical Items, and Surgical Fires: A Systematic Review. VA-ESP Project #05-226; 2014. Washington (DC): Department of Veterans Affairs; 2014 Jan. VA Evidence-based Synthesis Program Reports. http://www.hsrd.research.va.gov/publications/esp/wrong-site.cfm

HHempel S, Maggard-Gibbons M, Nguyen DK, Dawes AJ, Miake-Lye I, Beroes JM, Booth MJ, Miles JN, Shanman R, Shekelle PG. Wrong-Site Surgery, Retained Surgical Items, and Surgical Fires : A Systematic Review of Surgical Never Events. JAMA Surg. Aug 2015;150(8):796-805. PMID: 26061125 http://www.ncbi.nlm.nih.gov/pubmed/26061125

Hempel S, Taylor SL, Solloway MR, Miake-Lye IM, Beroes JM, Shanman R, Booth MJ, Siroka AM, Shekelle PG. (2014). Evidence Map of Acupuncture. VA-ESP Project #05-226; 2014. Washington (DC): Department of Veterans Affairs; 2014 Jan. VA Evidence-based Synthesis Program Reports. http://www.hsrd.research.va.gov/publications/management_briefs/default.cfm?ManagementBriefsMenu=eBrief-no78

HTaylor S, Hempel S, Solloway M, Miake-Lye I, Beroes J, Shekelle P (2014). An evidence map of the effects of acupuncture. J Altern Complement Med, 20(5): A91-2.

Department of Veterans Affairs Development of tools for evidence synthesis of quality improvement for use by VA’s Quality Enhancement and Research Initiative and other VA implementation researchers.

Lokker C, McKibbon KA, Colquhoun H, Hempel S. A scoping review of classification schemes of interventions to promote and integrate evidence into practice in healthcare. Implement Sci. 2015;10:27. PMID: 25885047 http://www.ncbi.nlm.nih.gov/pubmed/25885047

Colquhoun H, Leeman J, Michie S, Lokker C, Bragge P, Hempel S, McKibbon KA, Peters GJ, Stevens KR, Wilson MG, Grimshaw J. Towards a common terminology: a simplified framework of interventions to promote and integrate evidence into health practices, systems, and policies. Implement Sci. 2014;9:51. PMID: 24885553 http://www.ncbi.nlm.nih.gov/pubmed/24885553

Department of Veterans Affairs Electronic Health Record-based Interventions for Reducing Inappropriate Imaging in the Clinical Setting: A Systematic Review of the Evidence

Goldzweig C L, Orshansky G, Paige N M, Ewing B A, Miake-Lye I M, Beroes J M, Shekelle P G. Electronic Health Record-Based Interventions for Reducing Inappropriate Imaging in the Clinical Setting: A Systematic Review of the Evidence. VA-ESP Project #05-226; 2014.

Goldzweig CL, Orshansky G, Paige NM, Miake-Lye IM, Beroes JM, Ewing BA, Shekelle PG. Electronic health record-based interventions for improving appropriate diagnostic imaging: a systematic review and meta-analysis. Ann Intern Med. Apr 21 2015;162(8):557-565. PMID: 25894025

2014

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC Program Assessment of a method to detect signals for updating systematic reviews

Shekelle PG, Motala A, Johnsen B. Assessment of a Method To Detect Signals for Updating Systematic Reviews. Research White Paper (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I). AHRQ Publication No. 14-EHC015. Rockville, MD: Agency for Healthcare Research and Quality. March 2014.

Shekelle PG, Motala A, Johnsen B, Newberry SJ. Assessment of a method to detect signals for updating systematic reviews. Syst Rev. 2014;3:13. PMID: 24529068

AHRQ EPC Program Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update) Newberry SJ, Chung M, Shekelle PG, Booth MS, Liu JL, Maher AR, Motala A, Cui M, Perry T, Shanman R, Balk EM. Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update). Evidence Report/Technology Assessment No. 217. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2012-00006-I.) AHRQ Publication No. 14-E004-EF. Rockville, MD: Agency for Healthcare Research and Quality. September 2014.
AHRQ EPC Program Safety of Vaccines Used for Routine Immunization of Adults (Including Pregnant Women) and Children

Maglione MA, Gidengil C, Das L, Raaen L, Smith A, Chari R, Newberry S, Hempel S, Shanman R, Perry T, Goetz MB. Safety of Vaccines Used for Routine Immunization in the United States. Evidence Report/Technology Assessment No. 215. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I.) AHRQ Publication No. 14-E002-EF. Rockville, MD: Agency for Healthcare Research and Quality; July 2014.

Maglione MA, Das, L., Raaen L, Smith A, Chari R, Newberry S, Shanman R, Perry T, Goetz MB, Gidengil C. Safety of Vaccines Used for Routine Immunization of U.S. Children: A Systematic Review. Pediatrics. 2014; 134(2): 325-37

Office of the National Coordinator (ONC) Health Information Technology: An Updated Systematic Review with a Focus on Meaningful Use Functionalities

Shekelle P.G., Jones SS, Rudin BS, Shanman R, Timmer M, Perry TR, Motala A. Health Information Technology: An Updated Systematic Review with a Focus on Meaningful Use Functionalities. (Prepared by the Southern California-RAND Evidence-based Practice Center under Contract No. HHSP23337020T). 2014. Washington, D.C., Office of the National Coordinator for Health Information Technology.

Jones SS, Rudin RS, Perry T, Shekelle PG. Health Information Technology: An Updated Systematic Review with a Focus on Meaningful Use,”Ann Intern Med 2014;160:48-54 http://www.ncbi.nlm.nih.gov/pubmed/24573664

Department of Veterans Affairs CIPRS Research-Clinical Partnership Review Ovretveit J, Hempel S, Magnabosco J, Mittman B, Rubenstein L & Ganz D. Guidance for Research-Practice Partnerships (R-PPs) and Collaborative Research. In press with Journal of Health Organization and Management. 2014. 28(1). 115-126.
AHRQ EPC Program USAID Strength of Evidence Criteria

Shekelle PG, Maglione MA, Luoto J, Johnsen B, Perry TR. Global Health Evidence Evaluation Framework. Research White Paper (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I). AHRQ Publication No. 13-EHC008-EF. Rockville, MD: Agency for Healthcare Research and Quality. January 2013.

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Luoto J, Maglione MA, Johnsen B, Chang C, E SH, Perry T, Shekelle PG. Comparison of frameworks evaluating evidence for global health interventions. PLoS Med. Jul 2013;10(7):e1001469. http://www.ncbi.nlm.nih.gov/pubmed/23874159

Luoto J, Shekelle, PG., Maglione MA, Johnsen B, Perry T. Reporting of context and implementation in studies in global health interventions: a pilot study. May 12, 2014. Implementation Science. 9(57). http://www.ncbi.nlm.nih.gov/pubmed/24886201

RAND Probiotics for antibiotics-associated diarrhea

Hempel, S., Newberry, S., Maher, A., Wang, Z., Miles, J., Shanman, R., Johnsen, B. & Shekelle, P. (2012). Probiotics for the prevention and treatment of antibiotic-associated diarrhea: A systematic review and meta-analysis. JAMA, 307 (18), 1959-1969. http://www.ncbi.nlm.nih.gov/pubmed/22570464

Hempel S. Editorial: Probiotics for diarrhoea. Indian J Med Res. Mar 2014;139(3):339-341. http://www.ncbi.nlm.nih.gov/pubmed/24820827

AHRQ EPC program Safety of Probiotics Used to Reduce Risk and prevent or treat disease

Hempel S, Newberry S, Ruelaz A, Wang Z, Miles J, Suttorp M, Johnsen B, Shanman R, Slusser W, Fu N, Smith A, Roth E, Polak J, Motala A, Perry T, & Shekelle PG. Safety of Probiotics to Reduce Risk and Prevent or Treat Disease. Evidence Report/Technology Assessment No. 200. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I) AHRQ Publication No. 11-E007-1. Rockville, MD: Agency for Healthcare Research and Quality. April 2011

Shane, A.L., Cabana, M. D., Vidry, S., Merenstein, D., Hummelen, R. Ellis, C.L. Heimbach, J.T., Hempel, S., Lynch, S.V. Sanders, M.E. Tancredi, D.J. (2010). Guide to Designing, Conducting, Publishing, and Communicating Results of Clinical Studies Involving Probiotic Applications in Human Participants. Gut Microbes, 1(4).

2013

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program and VA Detection of Associations Between Trial Quality and Effect Sizes

Hempel, Susanne; Miles, Jeremy NV; Booth, Marika J; Wang, Zhen; Morton, Sally C; Shekelle, Paul G. Risk of Bias: A Simulation Study of Power to Detect Study-Level Moderator Effects in Meta-Analysis, Systematic Reviews, v. 2, no.107, Nov. 2013, 10 p. http://www.ncbi.nlm.nih.gov/pubmed/24286208

Hempel S, Miles J, Suttorp M, Wang Z, Johnsen B, Morton S, Perry, T., Valentine D, Shekelle P. Detection of Associations between Trial Quality and Effect Sizes. Methods Research Report. Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I. AHRQ Publication No. 12-EHC010-EF. Rockville, MD: Agency for Healthcare Research and Quality; December 2012. http://effectivehealthcare.ahrq.gov/ehc/products/267/921/Detection-of-Associations_Final-Report_20120110.pdf

AHRQ EPC Program Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m²

Maglione, M., Maggard Gibbons, M., Livhits, M., Ewing, B Hu, J., Ruelaz Maher, A., Li, Z., Shanman, R., Perry, T., Shekelle, P.G. Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m² Comparative Effectiveness Review No. 82. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I.) AHRQ Publication No. 12(13)-EHC139-EF. Rockville, MD: Agency for Healthcare Research and Quality. June 2013.

Maggard-Gibbons M, Maglione M, Livhits M, Ewing B, Maher AR, Hu J, Li Z, Shekelle PG. Bariatric surgery for weight loss and glycemic control in nonmorbidly obese adults with diabetes: a systematic review. JAMA. Jun 5 2013;309(21):2250-2261. http://www.ncbi.nlm.nih.gov/pubmed/23736734

AHRQ EPC Program Surveillance & Identification of Triggers for Updating Systematic Reviews

Newberry SJ, Ahmadzai N, Motala A, Tsertsvadze A, Maglione M, Ansari MT, Hempel S, Tsouros S, Schneider Chafen J, Shanman R, Skidmore, B, Moher D. Shekelle, PG. Surveillance and Identification of Signals for Updating Systematic Review: Implementation and Early Experience. Methods Research Report (Prepared by the RAND Corporation, Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I and University of Ottawa Evidence-based Practice Center 290-2007-10059-I). AHRQ Publication No. 13-EHC088-EF. Rockville, MD: Agency for Healthcare Research and Quality; May 2013. http://www.effectivehealthcare.ahrq.gov/reports/final.cfm

Ahmadzai N, Newberry SJ, Maglione MA, Tsertsvadze A, Ansari MT, Hempel S, Motala A, Tsouros S, Schneider Chafen JJ, Shanman R, Moher D, Shekelle PG. A surveillance system to assess the need for updating systematic reviews. Syst Rev. Nov 14 2013;2(1):104. http://www.ncbi.nlm.nih.gov/pubmed/24225065

Shekelle, PG. Motala, A, Newberry, SJ, Hempel, S, Chafen, JJ, Maglione, M, Shanman, R, Surveillance Assessment on CER 9: Percutaneous Coronary Interventions and Coronary Artery Bypass Grafting for Coronary Artery Disease (CER 9). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. May 2013

Chafen, JJ, Newberry, SJ, Maglione M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 13: Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer (CER 13). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. June 2012

Chafen, JJ, Newberry, SJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 17: Comparative Effectiveness of Medications To Reduce Risk of Primary Breast Cancer in Women. (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. July 2012.
http://effectivehealthcare.ahrq.gov/ehc/products/50/178/BreastCancer_SurveillanceAssessment_20120919.pdf
http://effectivehealthcare.ahrq.gov/ehc/products/50/178/PrimaryBreastCancer_SurveillanceAssesment_20120521.pdf

Primary Breast Cancer Surveillance Assessment

Maglione, M, Motala, A, Shanman, R, Chafen, JJ, Newberry, SJ, Shekelle, PG. Surveillance Assessment on CER 19: Comparative Effectiveness of Core Needle Biopsy and Open Surgical Biopsy for Diagnosis of Breast Lesions (CER 19). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. July 2012
http://effectivehealthcare.ahrq.gov/ehc/products/17/370/NeedleBiopsy_SurveillanceAssessment_20120919.pdf
http://effectivehealthcare.ahrq.gov/ehc/products/17/370/BreastBiopsy_SurveillanceAssessment_20120419.pdf

Breast Biopsy Surveillance Assessment

Newberry, SJ, Chafen, JJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 23: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patiewnts with Cystic Fibrosis (CER 23). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. August 2012

Cystic Fibrosis Surveillance Assesment

Newberry, SJ, Chafen, JJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 25: Traumatic Brain Injury and Depression (CER 25). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. November 2012
http://effectivehealthcare.ahrq.gov/ehc/products/77/1513/depression-brain-injury-surveillance-130524.pdf
http://effectivehealthcare.ahrq.gov/ehc/products/77/658/TBI-and-Depression_Surveillance-Assesment_20120502.pdf

TBI and Depression Surveillance Assesment

Maglione, M, Motala, A, Shanman, R, Chafen, JJ, Newberry, SJ, Shekelle, PG. Surveillance Assessment on CER 26: Therapies for Children with Autism Spectrum Disorders (ASDs) (CER 26). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. October 2012
http://effectivehealthcare.ahrq.gov/ehc/products/106/1536/autism-surveillance-121212.pdf
http://effectivehealthcare.ahrq.gov/ehc/products/106/656/TherapiesforChildrenWithAutism_UpdateSurveillanceReport_20120803.pdf

Therapies for Children With Autism Update Surveillance Report

Maher, AR, Shekelle, PG, Motala, A, Chafen, JJ, Newberry, SJ, Maglione, M, Shanman, R. Surveillance Assessment on CER 28: Disease-Modifying Antirheumatic Drugs (DMARDs) in Children with Juvenile Idiopathic Arthritis (JIA) (CER 28). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. February 2013

Chafen, JJ, Newberry, SJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 30: Comparative Effectiveness of Pain Management Interventions for Hip Fracture (CER 30). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. October 2012
http://effectivehealthcare.ahrq.gov/ehc/products/95/678/PainMgtHipFracture_SurveillanceRe-assesment_20121101.pdf
http://effectivehealthcare.ahrq.gov/ehc/products/95/678/PainMgtHipFracture_Surveillance-Assesment_20120502.pdf

Pain Management Hip Fracture Surveillance Assesment

Chafen, JJ, Newberry, SJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 31: Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection (CER 31). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. October 2012

Hempel, S, Newberry, SJ, Chafen, JJ, Maglione, M, Motala, A, Larkin, J, Shekelle, PG. Surveillance Assessment on CER 32: Diagnosis and Treatment of Obstructive Sleep Apnea in Adults (CER 32). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. July 2012

Newberry, SJ, Chafen, JJ, Maglione, M, Motala, A, Larkin, J, Shekelle, PG. Surveillance Assessment on CER 33: Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults (CER 33). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. August 2012

Maher, AR, Motala, A, Chafen, JJ, Newberry, SJ, Maglione, M, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 37: Chronic Kidney Disease Stages 1-3: Screening, Monitoring, and Treatment (CER 37). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. October 2012

Maglione, M, Motala, A, Larkin, JW, Chafen, JJ, Newberry, SJ, Shekelle, PG. Surveillance Assessment on CER 39: First & second generation antipsychotics for children and young adults (CER 39). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. November 2012

Hempel, S, Newberry, SJ, Chafen, JJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 41: Noncyclic Chronic Pelvic Pain Therapies for Women: Comparative Effectiveness (CER 41). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. October 2012

Shekelle, PG. Motala, A, Newberry, SJ, Hempel, S, Chafen, JJ, Maglione, M, Shanman, R, Surveillance Assessment on CER 42: Adjunctive Devices for Patients With Acute Coronary Syndrome Undergoing Percutaneous CoronaryIntervention (CER 42). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. May 2013

Maglione, M, Das, L, Motala, A, Shanman, R, Newberry, SJ, Chafen, JJ, Shekelle, PG. Surveillance Assessment on CER 44: Attention Deficit Hyperactivity Disorder (ADHD): Effectiveness of Treatment in At-Risk Preschoolers; Long-term Effectiveness in All Ages; and Variability in Prevalence, Diagnosis, and Treatment (CER 44). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. July 2012

Chafen, JJ, Newberry, SJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 47: Noninvasive Diagnostic Tests for Breast Abnormalities: Update of a 2006 Review (CER 47). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. January 2013

Maglione, M, Hempel, S, Newberry, SJ, Chafen, JJ, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 50: Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children (CER 50). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. March 2013

Newberry, SJ, Hempel, S, Chafen, JJ, Maglione, M, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 51: Dietary Supplements in Adults Taking Cardiovascular Drugs (CER 51). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. April 2013

Maglione, M, Hempel, S, Newberry, SJ, Chafen, JJ, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 54: Drug Therapy for Psoriatic Arthritis in Adults:Update of a 2007 Report (CER 54). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. March 2013

Maglione, M, Hempel, S, Newberry, SJ, Chafen, JJ, Motala, A, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 55: Drug Therapy for Rheumatoid Arthritis in Adults:An Update (CER 55). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. May 2013

Newberry, SJ, Chafen, JJ, Maglione, M, Motala, A, Larkin, J, Shekelle, PG. Surveillance Assessment on CER 56: Adjuvant Treatment for Phenylketonuria (CER 56). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. January 2013

Newberry, SJ, Motala, A, Hempel, S, Chafen, JJ, Maglione, M, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 59: Screening for Glaucoma: Comparative Effectiveness (CER 60). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. May 2013

Newberry, SJ, Motala, A, Hempel, S, Chafen, JJ, Maglione, M, Shanman, R, Shekelle, PG. Surveillance Assessment on CER 60: Treatment for Glaucoma: Comparative Effectiveness (CER 60). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. May 2013

Maglione, M, Motala, A, Larkin, J, Newberry, SJ, Chafen, JJ, Shekelle, PG. Surveillance Assessment on CER 62: Treatment of Depression after Unsatisfactory Response to SSRIs (CER 62). (Prepared by Southern California Evidence Based Practice Center under Contract No. 290-2007-10062I.) Rockville, MD: Agency for Healthcare Research and Quality. January 2013

AHRQ EPC Program Critical Analysis of the Evidence for Patient Safety Practices

Shekelle PG, Wachter RM, Pronovost P, Schoelles K, McDonald KM, Dy SM, et al. Making Health Care Safer II: An Updated Critical Analysis of the Evidence for Patient Safety Practices. (Prepared by the Southern California-RAND Evidence-based Practice Center under contract no. HHSA290200710062I.) Rockville, MD: Agency for Healthcare Research and Quality; March 5, 2013. http://www.ahrq.gov/research/findings/evidence-based-reports/ptsafetyII-full.pdf

Wachter RM, Pronovost P, Shekelle P. Strategies to improve patient safety: the evidence base matures. Ann Intern Med. Mar 5 2013;158(5 Pt 1):350-352. http://www.ncbi.nlm.nih.gov/pubmed/23460060

Shekelle PG, Pronovost PJ, Wachter RM, McDonald KM, Schoelles K, Dy SM, Shojania K, Reston JT, Adams AS, Angood PB, Bates DW, Bickman L, Carayon P, Donaldson L, Duan N, Farley DO, Greenhalgh T, Haughom JL, Lake E, Lilford R, Lohr KN, Meyer GS, Miller MR, Neuhauser DV, Ryan G, Saint S, Shortell SM, Stevens DP, Walshe K. The top patient safety strategies that can be encouraged for adoption now. Ann Intern Med. Mar 5 2013;158(5 Pt 2):365-368. http://www.ncbi.nlm.nih.gov/pubmed/23460091

Weaver SJ, Lubomksi LH, Wilson RF, Pfoh ER, Martinez KA, Dy SM. Promoting a culture of safety as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):369-374.

Reston JT, Schoelles KM. In-facility delirium prevention programs as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):375-380.

McDonald KM, Matesic B, Contopoulos-Ioannidis DG, Lonhart J, Schmidt E, Pineda N, Ioannidis JP. Patient safety strategies targeted at diagnostic errors: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):381-389.

Miake-Lye IM, Hempel S, Ganz DA, Shekelle PG. Inpatient fall prevention programs as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):390-396.

Kwan JL, Lo L, Sampson M, Shojania KG. Medication reconciliation during transitions of care as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):397-403.

Shekelle PG. Nurse-patient ratios as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):404-409.

Sullivan N, Schoelles KM. Preventing in-facility pressure ulcers as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):410-416.

Winters BD, Weaver SJ, Pfoh ER, Yang T, Pham JC, Dy SM. Rapid-response systems as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):417-425.

Schmidt E, Goldhaber-Fiebert SN, Ho LA, McDonald KM. Simulation exercises as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):426-432.

Rennke S, Nguyen OK, Shoeb MH, Magan Y, Wachter RM, Ranji SR. Hospital-initiated transitional care interventions as a patient safety strategy: a systematic review. Ann Intern Med. Mar 5 2013;158(5 Pt 2):433-440.

Berger Z, Flickinger TE, Pfoh E, Martinez KA, Dy SM. Promoting engagement by patients and families to reduce adverse events in acute care settings: a systematic review. BMJ Qual Saf. Jul 2014;23(7):548-555. PMID: 24336575

Carayon P, Xie A, Kianfar S. Human factors and ergonomics as a patient safety practice. BMJ Qual Saf. Mar 2014;23(3):196-205. PMID: 23813211

Lau BD, Haut ER. Practices to prevent venous thromboembolism: a brief review. BMJ Qual Saf. Mar 2014;23(3):187-195. PMID: 23708438

Maggard-Gibbons M. The use of report cards and outcome measurements to improve the safety of surgical care: the American College of Surgeons National Surgical Quality Improvement Program. BMJ Qual Saf. Jul 2014;23(7):589-599. PMID: 24748371

Meddings J. Interventions to reduce urinary catheter use: it worked for them, but will it work for us? BMJ Qual Saf. Dec 2013;22(12):967-971. PMID: 24050982

Ranji SR, Rennke S, Wachter RM. Computerised provider order entry combined with clinical decision support systems to improve medication safety: a narrative review. BMJ Qual Saf. Sep 2014;23(9):773-780. PMID: 24728888

Treadwell JR, Lucas S, Tsou AY. Surgical checklists: a systematic review of impacts and implementation. BMJ Qual Saf. Apr 2014;23(4):299-318. PMID: 23922403

Weaver SJ, Dy SM, Rosen MA. Team-training in healthcare: a narrative synthesis of the literature. BMJ Qual Saf. May 2014;23(5):359-372. PMID: 24501181

2012

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC Program Closing the Quality Gap

McDonald KM, Chang C, Schultz E. Through the Quality Kaleidoscope: Reflections on the Science and Practice of Improving Health Care Quality. Closing the Quality Gap: Revisiting the State of the Science. Methods Research Report. (Prepared by Stanford-UCSF Evidence-based Practice Center under Contract No. 290-2007-10062-I.) AHRQ Publication No. 13-EHC041-EF. Rockville, MD: Agency for Healthcare Research and Quality; February 2013.

McDonald KM, Schultz EM, Chang C. Evaluating the state of quality-improvement science through evidence synthesis: insights from the closing the quality gap series. Perm J. 2013 Fall;17(4):52-61. PMID: 24079357.

McDonald KM, Chang C, Schultz E. Closing the Quality Gap: Revisiting the State of the Science. Summary Report. (Prepared by Stanford-UCSF Evidence-based Practice Center under Contract No. 290-2007-10062-I.) AHRQ Publication No. 12(13)-E017. Rockville, MD: Agency for Healthcare Research and Quality. January 2013.

Hussey PS, Mulcahy AW, Schnyer C, Schneider EC. Bundled Payment: Effects on Health Care Spending and Quality. Closing the Quality Gap: Revisiting the State of the Science. Evidence Report/Technology Assessment No. 208. (Prepared by the RAND Evidence-based Practice Center under Contract No. 290-2007-10062-I.) AHRQ Publication No. 12-E007-EF. Rockville, MD: Agency for Healthcare Research and Quality. August 2012.

AHRQ EPC Program Machine Learning in QII Datasets Hempel S, Shetty KD, Shekelle PG, Rubenstein LV, Danz MS, Johnsen B, Dalal SR. Machine Learning Methods in Systematic Reviews: Identifying Quality Improvement Intervention Evaluations. Research White Paper (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I). AHRQ Publication No. 12-EHC125-EF. Rockville, MD: Agency for Healthcare Research and Quality. September 2012.
AHRQ EPC Program A Pilot Study using Machine Learning and Domain Knowledge to Facilitate Comparative Effectiveness Review Updating

Dalal, S.R., Shekelle, P.G., Hempel, S., Newberry, S.J., Motala, A., Shetty, K.D. Using Machine Learning to Facilitate Systematic Review Updating. Methods Research Report (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I). AHRQ Publication No. 11-EHC045-EF. Rockville, MD: Agency for Healthcare Research and Quality. September 2012.

Dalal SR, Shekelle PG, Hempel S, Newberry SJ, Motala A, Shetty KD. A pilot study using machine learning and domain knowledge to facilitate comparative effectiveness review updating. Med Decis Making. Apr 2013;33(3):343-355. http://www.ncbi.nlm.nih.gov/pubmed/22961102

AHRQ EPC Program Allocation of Scarce Resources During Mass Casualty Events (MCEs)

Timbie JW, Ringel JS, Fox DS, Waxman DA, Pillemer F, Carey C, Moore M, Karir V, Johnson TJ, Iyer N, Hu J, Shanman R, Larkin JW, Timmer M, Motala A, Perry TR, Newberry S, Kellermann AL. Allocation of Scarce Resources During Mass Casualty Events. Evidence Report No. 207. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I.) AHRQ Publication No. 12-E006-EF. Rockville, MD: Agency for Healthcare Research and Quality. June 2012.

Timbie JW, Ringel JS, Fox DS, Pillemer F, Waxman DA, Moore M, Hansen CK, Knebel AR, Ricciardi R, Kellermann AL. Systematic review of strategies to manage and allocate scarce resources during mass casualty events. Ann Emerg Med. Jun 2013;61(6):677-689 e101. http://www.ncbi.nlm.nih.gov/pubmed/23522610

AHRQ EPC program Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis – An Update of the 2007 Report

Crandall CJ, Newberry SJ, Gellad WG, Diamant A, Lim YW, Suttorp M, Motala A, Ewing B, Roth B, Timmer M, Shanman R, Shekelle PG. Treatment to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis: Update of a 2007 Report. Comparative Effectiveness Review No. 53. (Prepared by Southern California Evidence-based Practice Center under Contract No. HHSA-290-2007-10062-I.) Rockville, MD: Agency for Healthcare Research and Quality; March 2012.

Crandall CJ, Newberry SJ, Diamant A, Lim YW, Gellad WG, Suttorp MJ, Motala A, Shekelle PG. Comparative Effectiveness of Pharmacological Treatments to Prevent Fractures: An Updated Systematic Review. Ann Intern Med. 2014. 161(10): 711-723. http://www.ncbi.nlm.nih.gov/pubmed/25199883

Included Studies from the 2014 Annals paper (PDF)

AHRQ Review of the evidence on falls prevention in hospitals

Hempel S, Newberry S, Wang Z, Shekelle PG, Shanman R, Johnsen B, Perry T, Saliba D, Ganz DA. Review of the evidence on falls prevention in hospitals: Task 4 Final Report. AHRQ Contract No. HHSA290201000017I, PRISM No. HHSA29032001T, Task Order #1. WR-907. Santa Monica, California. RAND Corporation. February 2012.

Hempel S, Newberry S, Wang Z, Booth M, Shanman R, Johnsen B, Shier V, Saliba D, Spector WD, Ganz DA. Hospital fall prevention: a systematic review of implementation, components, adherence, and effectiveness. J Am Geriatr Soc. Apr 2013;61(4):483-494. http://www.ncbi.nlm.nih.gov/pubmed/23527904

Hempel S, Ganz D, Shekelle P, Johnsen B, Wang Z, Newberry S, D. S. Implementation of falls prevention interventions in hospitals. Implementation of falls prevention interventions in hospitals. PROSPERO 2011 CRD42011001593. http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42011001593

2011

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update

Maglione M, Ruelaz Maher A, Hu, J, Wang Z, Shanman R, Shekelle PG, Roth B, Hilton L, Suttorp MJ, Ewing BA, Motala A, Perry T. Off-Label Use of Atypical Antipsychotics Update. Evidence Report/ Technology Assessment No. 43. (Prepared by the Southern California Evidence-based Practice Center under Contract No. HHSA290200710062I). Rockville, MD: Agency for Healthcare Research and Quality. September 2011. http://effectivehealthcare.ahrq.gov/ehc/products/150/778/CER43_Off-LabelAntipsychotics_20110928.pdf

Ruelaz Maher, A, Maglione, M, Bagley, S, Suttorp, M, Hu, J, Ewing, B, Wang, Z, Timmer, M, Sultzer, D, Shekelle, PG. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA. Sep 28 2011;306(12):1359-1369. http://www.ncbi.nlm.nih.gov/pubmed/21954480

AHRQ EPC program Empirical evidence of associations between trial quality and effect sizes Hempel S, Suttorp MJ, Miles JNV, Wang Z, Maglione M, Morton S, Johnsen B, Valentine D, Shekelle PG. Empirical Evidence of Associations Between Trial Quality and Effect Sizes. Methods Research Report (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I). AHRQ Publication No. 11-EHC045-EF. Rockville, MD: Agency for Healthcare Research and Quality. June 2011. Available at: http://effectivehealthcare.ahrq.gov/ehc/products/319/710/Assessing-Empirical-Evidence_Final-Report_20110621.pdf
AHRQ EPC program Identifying Signals for Updating Systematic Reviews: A Comparison of Two Methods

Shekelle PG, Newberry, SJ, Wu, H, Suttorp M, Motala, A., Lim Y-W, Balk EM, Chung, M, Yu, WW, Lee, J, Gaylor, JM, Moher, D, Ansari, MT, Skidmore, R. Garritty, C. Identifying Signals for Updating Systematic Reviews: A Comparison of Two Methods. Rockville (MD): Agency for Healthcare Research and Quality. June 2011. Methods Research Report. AHRQ Publication No. 11-EHC042-EF.

Chung M, Newberry SJ, Ansari MT, Yu WW, Wu H, Lee J, Suttorp M, Gaylor JM, Motala A, Moher D, Balk EM, Shekelle PG. Two methods provide similar signals for the need to update systematic reviews. J Clin Epidemiol. Jun 2012;65(6):660-668.

Department of Veterans Affairs Quality improvement interventions for the prevention of pressure ulcers Soban LM, Hempel S, Munjas BA, Miles J, Rubenstein LV. Preventing pressure ulcers in hospitals: A systematic review of nurse-focused quality improvement interventions. Jt Comm J Qual Patient Saf. Jun 2011;37(6):245-252.
Robert Wood Johnson Foundation, Department of Veterans Affairs Defining Continuous Quality Improvement (CQI) for Health Care Delivery

Rubenstein, L., Danz, M., Hempel, S., O'Neil, S. & Shekelle, P.G. (2011). Defining continuous quality improvement (CQI) for health care delivery. Final project report. May 2011.

Khodyakov D, Hempel S, Rubenstein L, Shekelle P, Foy R, Salem-Schatz S, O'Neill S, Danz M, Dalal S. Conducting Online Expert Panels: A Feasibility and Experimental Replicability Study. BMC Med Res Methodol. 2011 Dec 23;11(1):174.

Rubenstein L, Khodyakov D, Hempel S, Danz M, Salem-Schatz S, Foy R, O'Neill S, Dalal S, Shekelle P. How can we recognize continuous quality improvement? Int J Qual Health Care. Dec 4 2013.

CMS Outcome Measures for Medicare Hempel, S, Ganz, DA, Clifford, M, Newberry, S, Lim, Y-W, Larkin, J, Shanman, RA, Wertheimer, S, Wenger, NS, Roth, CP, Shekelle, PG. Review of the Current Literature on Outcome Measures Applicable to the Medicare Population for Use in a Quality Improvement Program. Prepared for CMS, Contact No. HHSM-500-2005-00028I. RAND Corporation. February 2011
Department of Veterans Affairs Veterans Assessment and Improvement Laboratory-Patient Aligned Care Team Program - Evidence Review Workgroup

Evidence review work group (2011). Advanced Access. Rapid review. DOI: 10.13140/RG.2.2.23397.45283.

Evidence review work group (2011). Homelessness. Rapid review. DOI: 10.13140/RG.2.2.23436.77446.

Evidence review work group (2011). PCMH Evaluation Measures, Rapid review. DOI: 10.13140/RG.2.2.30147.66081.

Evidence review work group (2011). Patient Registries. Rapid review. DOI: 10.13140/RG.2.2.13370.44482.

Evidence review work group (2011). Mental Health and PCMH. Rapid review. DOI: 10.13140/RG.2.2.26792.21764.

Evidence review work group (2011). Role of Pharmacists. Rapid review. DOI: 10.13140/RG.2.2.20081.33126.

Evidence review work group (2011). Primary Care Team Functioning. Rapid review. DOI: 10.13140/RG.2.2.11692.72323.

Evidence review work group (2011). Readmissions. Rapid review. DOI: 10.13140/RG.2.2.18403.60969.

Evidence review work group (2011). Relational Coordination. Rapid review. DOI: 10.13140/RG.2.2.28469.93924.

Evidence review work group (2011). Secure Messaging. Rapid review. DOI: 10.13140/RG.2.2.24275.63520.

Evidence review work group (2011). Self-Management. Rapid review. DOI: 10.13140/RG.2.2.30986.52166.

Evidence review work group (2011). Motivational Interviewing. Rapid review. DOI: 10.13140/RG.2.2.14209.30566.

Evidence review work group (2011). Interactive communication. Rapid review. DOI: 10.13140/RG.2.2.27631.07848.

Evidence review work group (2012). Role of Nursing in Patient Centered Medical Homes (PCMH) / Patient Aligned Care Teams (PACT) – Examples from the literature. Rapid review. DOI: 10.13140/RG.2.2.20920.19201.

Evidence review work group (2012). Primary Care Clinician Burnout and Large-Scale Practice Changes. Rapid review. DOI: 10.13140/RG.2.2.34341.96484.

Evidence review work group (2012). Guided Imagery. Rapid review. DOI: 10.13140/RG.2.2.12531.58407.

Evidence review work group (2012). Medication Renewal via Interactive Voice Response Systems. Rapid review. DOI: 10.13140/RG.2.2.25953.35680.

Evidence review work group (2012). Primary Care Resident Training and Quality Improvement in Mental Health. Rapid review. DOI: 10.13140/RG.2.2.19242.47043.

Evidence review work group (2013). Measuring Homelessness. Rapid review. DOI: 10.13140/RG.2.2.32664.24324.

Danz MS, Hempel S, Lim YW, Shanman R, Motala A, Stockdale S, Shekelle P, Rubenstein L. Incorporating evidence review into quality improvement: meeting the needs of innovators. BMJ Qual Saf. Nov 2013;22(11):931-939.

2010

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ Developing Criteria for Context Sensitive Patient Safety Practices

Shekelle PG, Pronovost PJ, Wachter RM, Taylor SL, Carr L, Dy S, Foy R, Hempel S, McDonald K, Ovretveit J, Rubenstein L, and the PSP Technical Expert Panel. Assessing the Evidence for Context-Sensitive Effectiveness and Safety of Patient Safety Practices: Developing Criteria (Prepared under Contract No. HHSA-290-2009-10001C). AHRQ Publication No. 11-0006-EF. Rockville, MD: Agency for Healthcare Research and Quality; December 2010.

Foy R, Ovretveit J, Shekelle PG, Pronovost PJ, Taylor SL, Dy S, Hempel S, McDonald KM, Rubenstein LV, Wachter RM. The role of theory in research to develop and evaluate the implementation of patient safety practices. BMJ Qual Saf. 2011 May;20(5):453-9.

Shekelle PG, Pronovost PJ, Wachter RM, Taylor SL, Dy SM, Foy R, Hempel S, McDonald KM, Ovretveit J, Rubenstein LV, Adams AS, Angood PB, Bates DW, Bickman L, Carayon P, Donaldson L, Duan N, Farley DO, Greenhalgh T, Haughom J, Lake ET, Lilford R, Lohr KN, Meyer GS, Miller MR, Neuhauser DV, Ryan G, Saint S, Shojania KG, Shortell SM, Stevens DP, Walshe K. Advancing the science of patient safety. Ann Intern Med. 2011 May 17;154(10):693-6.

Ovretveit JC, Shekelle PG, Dy SM, McDonald KM, Hempel S, Pronovost P, Rubenstein L, Taylor SL, Foy R, Wachter RM. How does context affect interventions to improve patient safety? An assessment of evidence from studies of five patient safety practices and proposals for research. BMJ Qual Saf. 2011 Jul;20(7):604-10.

Taylor SL, Dy S, Foy R, Hempel S, McDonald KM, Ovretveit J, Pronovost PJ, Rubenstein LV, Wachter RM, Shekelle PG. What context features might be important determinants of the effectiveness of patient safety practice interventions? BMJ Qual Saf. 2011 Jul;20(7):611-7.

Dy SM, Taylor SL, Carr LH, Foy R, Pronovost PJ, Ovretveit J, Wachter RM, Rubenstein LV, Hempel S, McDonald KM, Shekelle PG. A framework for classifying patient safety practices: results from an expert consensus process. BMJ Qual Saf. 2011 Jul;20(7):618-24.

AHRQ EPC program Management of Acute Otitis Media: Update

Shekelle PG, Takata G, Newberry SJ, Coker, T, Limbos M, Chan LS, Timmer M, Suttorp M, Carter J, Motala A, Valentine D, Johnsen B, Shanman R. Management of Acute Otitis Media: Update. Evidence Report/ Technology Assessment No. 198. (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290 2007 10056 I). Rockville, MD: Agency for Healthcare Research and Quality. November 2010.

Coker TR, Chan LS, Newberry SJ, Limbos MA, Suttorp MJ, Shekelle PG, Takata GS. Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review. JAMA. Nov 17 2010;304(19):2161-2169.

National Institute of Allergy and Infectious Diseases (NIAID) Incidence, Prevalence, Diagnosis, Treatment and Management of Food Allergy

Schneider Chafen, Jennifer J., Sydne Newberry, Marc Riedl, Dena M. Bravata, Margaret Maglione, Marika Suttorp, Vandana Sundaram, Neil M. Paige, Ali Towfigh, Benjamin J. Hulley and Paul G. Shekelle. Prevalence, Natural History, Diagnosis and Treatment of Food Allergy: The State of the Research. Santa Monica, CA: RAND Corporation, August 2010.

Schneider-Chafen, J., S, Newbery, M. Riedl, D. Bravata, M. Maglione, M. Suttorp, V. Sundaram, N. Paige, A. Towfigh, B. Hulley, P.G Shekelle (2010). Diagnosing and Managing Common Food Allergies: A Systematic Review. JAMA. 303(18):1848-56

Health Services Resource Administration (HRSA) Psychosocial Treatment of Autism in Children

Maglione, M., Gans, D., Timbie, J., Das, L., Munjas, B. A., Suttorp, M., & Timmer M. (April 2010). Draft: Systematic Review of the Evidence on Psychosocial and Related Interventions for Children with Autism. Rockville, MD: U.S. Department of Health and Human Services, Health Resources and Services Administration.

Maglione MA, Gans D, Das L, Timbie J, Kasari C. interventions for children with ASD: recommended guidelines and further research needs. Pediatrics. 2012 Nov;130 Suppl 2:S169-78.

RAND, Health Foundation, University of Newcastle Collaboration between primary care and specialists Foy R, Hempel S, Rubenstein L, Suttorp M, Seelig M, Shanman R, Shekelle P: Meta analysis: Effect of Interactive Communication Between Collaborating Primary Care Physicians and Specialists. Ann Intern Med 2010, 152:247-258.

2009

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program Assessment of the Need to Update Comparative Effectiveness Reviews: Report of an Initial Rapid Program Assessment (2005-2009) Shekelle PG, Newberry S, Maglione M, Shanman R, Johnsen B, Carter J, Motala A, Hulley B, Wang Z, Bravata D, Chen M, Grossman M. Assessment of the need to update comparative effectiveness reviews. Rockville, MD: Agency for Healthcare Research and Quality: October 2009.
The Health Foundation, England Health Information Technology

Shekelle, PG, Goldzweig, CL. Costs and benefits of health information technology: an updated systematic review. Southern California Evidence-based Practice Center. RAND Corporation. Produced as part of the Quest for Quality and Improved Performance (QQUIP), an initiative of the Health Foundation. 2009

Goldzweig CL, Towfigh A, Maglione M, Shekelle PG. Costs and benefits of health information technology: new trends from the literature. Health Aff (Millwood). 2009 Mar-Apr;28(2):w282-93.

Department of Veterans Affairs Determining key features of effective depression interventions

Rubenstein LV, Williams JW Jr, Danz M, Shekelle P, Suttorp M, Johnsen B. Determining Key Features of Effective Depression Interventions. Department of Veteran Affairs & Health Services Research & Development Service —Evidence-based Synthesis Program. Washington, DC 20420

2008

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program Bariatric surgery in women of reproductive age: Special concerns for pregnancy

Maggard M, Maglione, M, Shekelle, PG, Li, Z, Yermilov, I, Newberry, S, Hilton, L, Suttorp, M, Carter, J, Chen, S, Tringale, C, Johnsen, B, Hilton, L. Bariatric Surgery in Women of Reproductive Age: Special Concerns for Pregnancy. Agency for Healthcare Research and Quality, Rockville, MD, Publication No. 08-E013, November 2008

Maggard MA, Yermilov I, Li Z, Maglione M, Newberry S, Suttorp M, Hilton L, Santry HP, Morton JM, Livingston EH, Shekelle PG. Pregnancy and fertility following bariatric surgery: a systematic review. JAMA. 2008 Nov 19;300(19):2286-96.

AHRQ Identifying, Categorizing, and Evaluating Healthcare Efficiency Measures

McGlynn, EA, Shekelle, PG, Chen, S, Goldman, D, Romley, J, Hussey, P, de Vries, H, Wang, M, Timmer, M, Carter, J, Tringale, C, Shanman, R. Identifying, Categorizing, and Evaluating Healthcare Efficiency Measures. Evidence Report/Technology Assessment. Rockville, MD. AHRQ. April 2008

Hussey PS, de Vries H, Romley J, Wang MC, Chen SS, Shekelle PG, McGlynn EA. A systematic review of health care efficiency measures. Health Serv Res. Jun 2009;44(3):784-805.

Romley JA, Hussey PS, de Vries H, Wang MC, Shekelle PG, McGlynn EA. Efficiency and its measurement: what practitioners need to know. Am J Manag Care. Nov 2009;15(11):842-845.

AHRQ EPC program Comparative effectiveness of treatments to prevent fractures in men and women with low bone density (Including Osteoporosis)

MacLean, C, Alexander, A, Carter, J, Chen, S, Desai, SB, Grossman, J, Maglione, M, McMahon, M, McNamara, M, Mojica, W, Newberry, S, Ranganath, V, Suttorp, M, Timmer, M, Triangle, C, Valentine, D, Zhou, A. Comparative Effectiveness of Treatments for Low Bone Density. Evidence Report/Technology Assessment. Rockville, MD: AHRQ. 2007.

MacLean C, Newberry S, Maglione M, McMahon M, Ranganath V, Suttorp M, Mojica W, Timmer M, Alexander A, McNamara M, Desai SB, Zhou A, Chen S, Carter J, Tringale C, Valentine D, Johnsen B, Grossman J. Systematic Review: Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis. Ann Intern Med. 2008;148 (3):197-213

AHRQ EPC program End of life care and outcomes

Lorenz K, Lynn J, Morton SC, Dy S, Mularski R, Shugarman L, Sun V, Wilkinson AM, Maglione M, Shekelle PG. End-of-Life Care and Outcomes. Evidence Report/Technology Assessment No. 110 (Prepared by the Southern California Evidence-based Practice Center under Contract No. 290-02-0003.) A HRQ Publication No.05-E004-2. Rockville, MD: Agency for Healthcare Research and Quality. October 2004.

Lorenz KA, Lynn J, Morton SC, Dy SM, Shugarman LM, Wilkinson A, Mularski RA, Sun VC, Hughes RG, Rhodes SL, Maglione M, Hilton LK, Rolon C, Shekelle PG. Methodological approaches for a systematic review of end-of-life care. J Palliat Med 2005;8(Suppl1):S4-11.

Lorenz KA, Lynn J, Dy SM, Shugarman LR, Wilkinson A, Mularski RA, Morton SC, Hughes RG, Hilton LK, Maglione M, Rhodes SL, Rolon C, Sun VC, Shekelle PG. Evidence for Improving Palliative Care at the End of Life: A Systematic Review. Ann Intern Med 2008 Jan;148(2):147-159.

Dy SM, Shugarman LR, Lorenz KA, Mularski RA, Lynn J. A systematic review of satisfaction with care at the end of life. J Am Geriatr Soc. Jan 2008;56(1):124-129.

Kutner, JS. Editorial - Assuring Quality End-of-Life Care: Imperative to Expand the Evidence Base in Concert with Growth of the Field Jean S. Kutner, MD, MSPH; Journal of the American Geriatric Society (JAGS), January 2008; Vol. 56, No. 1, pp. 160-162.

2007

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program Resistance to antiretroviral (ARV) medications in the developing world Maglione M, Gotz M, Wang Z, Wagner G, Hilton L, Carter J, Tringale C, Newberry S, Shekelle P. Antiretroviral (ARV) Drug Resistance in the Developing World. Evidence Report/Technology Assessment No. 156. Rockville, MD: Agency for Healthcare Research and Quality, No. 07-E014, Sept 2007.
AHRQ EPC program Preventing violence and related high risk social behaviors in adolescents

Chan, L, Kipke, MD, Schneir, A, Iverson, E, Warf, C, Limbos, MA, Shekelle, PG. Preventing violence and related health-risking social behaviors in adolescents. Evid Rep Technol Assess (Summ) 2004 Sep; (107):1-7.

Limbos MA, Chan LS, Warf C, Schneir A, Iverson E, Shekelle P, Kipke MD. Effectiveness of interventions to prevent youth violence a systematic review. Am J Prev Med. Jul 2007;33(1):65-74.

American College of Physicians Foundation Patient Provider Communication Shrank W, Avorn J, Rolon C, and Shekelle P. Effect of content and format of prescription drug labels on readability, understanding, and medication use: a systematic review. Ann Pharmacother. 2007 May; 41(5):783-801.
DERP Drug class review on newer antiplatelet agents Dailey JH, Glassman P, Suttorp M, and Chen S. Drug Class Review on Newer Antiplatelet Agents. Southern California Evidence-based Practice Center. Portland, Oregon: Oregon Health & Science University. September 2006.
AHRQ EPC program Efficacy and comparative effectiveness of off-label use of atypical antipsychotics Shekelle P, Maglione M, Bagley S, Suttorp M, Mojica WA, Carter J, Rolon C, Hilton L, Zhou A, Chen S, Glassman P. Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics. Comparative Effectiveness Review No. 6. (Prepared by the Southern California/RAND Evidence-based Practice Center under Contract No. 290-02-0003.) Rockville, MD: Agency for Healthcare Research and Quality. January 2007.

2006

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program Cancer care quality measures: symptoms and end of life care

Lorenz, K, Joanne, L, Shekelle, PG, Morton, SC, Dy, S, Hughes, R, Mularski, RA, Shugarman, LR, Wilkinson, AM, Newberry, SJ, Rastegar A, Rolón, C, Chen, S. Cancer Care Quality Measures: Symptoms and End-of-Life Care. Evidence Report/Technology Assessment No. 137. AHRQ Publication No. 06-E001. Rockville, MD: AHRQ. May 2006.

Lorenz KA, Lynn J, Dy S, Wilkinson A, Mularski RA, Shugarman LR, Hughes R, Asch SM, Rolon C, Rastegar A, Shekelle PG. Quality measures for symptoms and advance care planning in cancer: a systematic review. J Clin Oncol 2006;24:4933-4938.

AHRQ EPC program Costs and benefits of health information technology

Shekelle PG, Morton S, Keeler EB. Costs and Benefits of Health Information Technology, Evidence Report/Technology Assessment No. 132. (Prepared by Southern California Evidence-Based Practice Center/RAND under Contract No 290-97-0001.) AHRQ Publication. Rockville, MD: Agency for Healthcare Research and Quality, April 2006.

Chaudhry B, Wang J, Wu S, Maglione M, Mojica W, Roth E, Morton SC, Shekelle PG. Systematic review: impact of health information technology on quality, efficiency, and costs of medical care. Ann Intern Med 2006;144:742-752.

AHRQ EPC program Effects of Omega-3 fatty acids on cognitive function with aging, dementia, and neurological disease

MacLean CH, Issa AM, Newberry SJ, Mojica WA, Morton SC, Garland RH, Hilton LG, Traina SB, Shekelle PG. Effects of Omega-3 Fatty Acids on Cognitive Function with Aging, Dementia, and Neurological Diseases, Evidence Report/Technology Assessment No. 114 Rockville, MD: Agency for Healthcare Research and Quality, Feb 2005.

Issa AM, Mojica WA, Morton SC, Traina S, Newberry SJ, Hilton LG, Garland RH, Maclean CH. The efficacy of omega-3 fatty acids on cognitive function in aging and dementia: a systematic review. Dement Geriatr Cogn Disord 2006;21:88-96.

AHRQ EPC program Effect of Omega-3 fatty acids on cancer

MacLean CH, Newberry SJ, Mojica, WA, Issa A, Khanna P, Lim YW, Morton SC, Suttorp M, Tu W, Hilton LG, Garland RH, Traina SB, Shekelle PG. Effects of Omega-3 Fatty Acids on Cancer. Evidence Report/Technology Assessment No. 113 (Prepared by the Southern California Evidence-based Practice Center, under Contract No. 290-02-0003). AHRQ Publication No. 05-E010-2. Rockville MD. Agency for Healthcare Research and Quality. February 2005.

MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, Lim YW, Traina SB, Hilton L, Garland R, Morton SC. Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA. 2006 2;295:403-415.

AHRQ EPC program Effects of supplemental antioxidants for prevention and treatment of cancer

Shekelle P, Hardy M, Morton SC, Udani J, Oda K, Jungvig LK, Tu W, Shanman R, Newberry SJ, Ramirez L, Valentine D. Effect of the Supplemental Use of Antioxidants Vitamin C, Vitamin E, and the Coenzyme Q10 for the Prevention and Treatment of Cancer. Evidence Report/Technology Assessment No. 75 (Prepared by Southern California-RAND Evidence-based Practice Center, under Contract No 290-97-0001). AHRQ Publication No. 03-E043. Rockville, MD: Agency for Healthcare Research and Quality. July 2003.

Coulter ID, Hardy ML, Morton SC, Hilton LG, Tu W, Valentine D, Shekelle PG. Antioxidants vitamin C and vitamin e for the prevention and treatment of cancer. J Gen Intern Med 2006;21:735-744.

2005

Funding Agency Project Topic Journal Articles and Evidence Reports
CMS Chronic Disease Self-Management for Diabetes, Osteoarthritis, Post-Myocardial Infarction Care, and Hypertension

Chodosh J, Mojica W, Morton S, Suttorp M, Roth E, Jungvig L, Wu S, Shekelle P, Rubenstein L, and Maglione M. Chronic Disease Self-Management for Diabetes, Osteoarthritis, Post-Myocardial Infarction Care, and Hypertension. Evidence Report prepared for the US Department of Health and Human Services, Health Care Financing Administration, 7500 Security Blvd., Baltimore MD. 21244-1850, Contract No. 500-98-0281.

Chodosh, J.; Morton, S. C.; Mojica, W.; Maglione, M.; Suttorp, M. J.; Hilton, L.; Rhodes, S., and Shekelle, P. Meta-analysis: chronic disease self-management programs for older adults. Ann Intern Med. 2005 Sep 20; 143(6):427-38.

AHRQ EPC program Ayurvedic Treatments for Diabetes Mellitus

Hardy M, Coulter I, Venuturupalli S, Roth EA, Favreau J, Morton SC, Shekelle P. Ayurvedic Interventions for Diabetes Mellitus: A Systematic Review Evidence Report/Technology Assessment No. 41 Agency for Healthcare Research and Quality, Rockville, MD, Publication No.01-E040, September 2001.

Shekelle PG, Hardy M, Morton SC, Coulter I, Venuturupalli S, Favreau J, Hilton LK. Are Ayurvedic herbs for diabetes effective? J Fam Pract 2005;54:876-886.

AHRQ EPC program Pharmacological and surgical treatment of obesity

Shekelle PG, Morton SC, Maglione MA, Suttorp M, Tu W, Li Z, Maggard M, Mojica WA, Shugarman L, Solomon V, Jungvig L, Newberry SJ, Mead D, Rhodes S. Pharmacological and Surgical Treatment of Obesity. Evidence Report/Technology Assessment No. 103. (Prepared by the Southern California-RAND Evidence-Based Practice Center, Santa Monica, CA, under contract Number 290-02-0003.) AHRQ Publication No. 04-E028-2. Rockville, MD: Agency for Healthcare Research and Quality. July 2004.

Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman LR, Hilton L, Suttorp M, Solomon V, Shekelle PG, Morton SC. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med 2005;142:532-546.

Maggard MA, Shugarman LR, Suttorp M, Maglione M, Sugerman HJ, Livingston EH, Nguyen NT, Li Z, Mojica WA, Hilton L, Rhodes S, Morton SC, Shekelle PG. Meta-analysis: surgical treatment of obesity. Ann Intern Med 2005;142:547-559.

AHRQ EPC program EPC Methods Annals Supplement Shekelle PG, Morton SC, Suttorp MJ, Buscemi N, Friesen C. Challenges in systematic reviews of complementary and alternative medicine topics. Ann Intern Med 2005;142(12 Pt 2):1042-1047.
AHRQ EPC program Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects

Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagne J. Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects. Evidence Report/Technology Assessment No. 76 (Prepared by the SCEPC, RAND, AHRQ) Pub. No. 03-E022, Rockville MD, February 2003.

Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagné J. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. JAMA. 2003;289:1537-1545.

Maglione M, Miotto K, Iguchi M, Hilton L, Shekelle P. Psychiatric symptoms associated with ephedra use. Expert Opin Drug Saf 2005;4:879-884.

Maglione M, Miotto K, Iguchi M, Jungvig L, Morton SC, Shekelle PG. Psychiatric effects of ephedra use: an analysis of Food and Drug Administration reports of adverse events. Am J Psychiatry 2005;162:189-191.

AHRQ EPC program Omega-3 Fatty Acids, Effects in Type II Diabetes, Rheumatoid Arthritis, and Other Diseases

MacLean CH, Mojica, WA, Morton SC, Pencharz J, Hasenfeld Garland R, Tu W, Newberry SJ, Jungvig LK, Grossman J, Khanna P, Rhodes S, Shekelle P. Effects of Omega-3 Fatty Acids on Lipids and Glycemic Control in Type II Diabetes and the Metabolic Syndrome and on Inflammatory Bowel Disease, Rheumatoid Arthritis, Renal Disease, Systemic Lupus Erythematosus, and Osteoporosis. Evidence Report/Technology Assessment. No. 89 (Prepared by Southern California/RAND Evidence-based Practice Center, under Contract No. 290-02-0003). AHRQ Publication No. 04-E012-2. Rockville, MD: Agency for Healthcare Research and Quality. March 2004.

MacLean CH, Mojica WA, Morton SC, Pencharz J, Hasenfeld Garland R, Tu W, Newberry SJ, Jungvig LK, Grossman J, Khanna P, Rhodes S, Shekelle P. Systematic review of the effects of n-3 fatty acids in inflammatory bowel disease. Am J Clin Nutr 2005;82:611-619.

2004

Funding Agency Project Topic Journal Articles and Evidence Reports
DERP Antiepileptic Drugs in Bipolar Mood Disorder and Neuropathic Pain Goodman F, Glassman P, Maglione M, Suttorp M, Rhodes S, Ma Q, Rolon C, Shekelle P. Drug Class Review on Antiepileptic Drugs in Bipolar Mood Disorder and Neuropathic Pain. Southern California Evidence-based Practice Center. Portland, Oregon: Oregon Health & Science University. August 2004.
DERP Angiotension Receptor Blockers Furmaga E, Glassman P, and Rhodes S. Drug Class Review on Angiotensin II Receptor Antagonists. Southern California Evidence-based Practice Center. Portland, Oregon: Oregon Health & Science University. June 2004.
CMS Interventions to Promote Smoking Cessation in the Medicare Population

Shekelle P, Stone E, Maglione M, Boyle K, Hoffman V, Klein K, Mojica W, Vaughn G, Morton S, Roth E, Chao B, Wu S, and Joyce G. Interventions to Promote Smoking Cessation in the Medicare Population. Evidence Report prepared for the US Department of Health and Human Services, Health Care Financing Administration, 7500 Security Blvd., Baltimore MD. 21244-1850, Contract No. 500-98-0281.

Mojica, W. A.; Suttorp, M. J.; Sherman, S. E.; Morton, S. C.; Roth, E. A.; Maglione, M. A.; Rhodes, S. L., and Shekelle, P. G. Smoking-cessation interventions by type of provider: a meta-analysis. Am J Prev Med. 2004 Jun; 26(5):391-401.

AHRQ EPC program Meta-regression approaches: what, why, when, and how? Morton SC, Adams JL, Suttorp MJ, Shanman R, Valentine D, Rhodes S, Shekelle PG. Meta-regression Approaches: What, Why, When, and How? Technical Review 8. AHRQ Publication No. 04-0033. Rockville, ME: AHRQ. March 2004.
CMS Falls Prevention Interventions in the Medicare Population

Shekelle P, Rubenstein L, Maglione M, Chang J, Mojica W, Morton S, Suttorp M, Roth E, Rhodes S, Wu S, Newberry S. Falls Prevention Interventions in the Medicare Population. Evidence Report prepared for the US Department of Health and Human Services, Health Care Financing Administration, 7500 Security Blvd., Baltimore MD. 21244-1850, Contract No. 500-98-0281.

Chang, J. T.; Morton, S. C.; Rubenstein, L. Z.; Mojica, W. A.; Maglione, M.; Suttorp, M. J.; Roth, E. A., and Shekelle, P. G. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ. 2004 Mar 20; 328(7441):680.

AHRQ EPC program Determinants of increases in Medicare expenditure for physicians' services

Buntin MB, Morton S, Shekelle PG, Laugesen M, Goldman D, Kan H, Escarce J, McKinnon E, Rhodes S. Determinants of increases in Medicare expenditures for physicians' services. Technical Review 7. AHRQ Publication No. 04-0008. Rockville, MD: AHRQ. October 2003.

Buntin MJ, Escarcé JJ, Goldman D, Kan H, Laugesen MJ, Shekelle P. Increased Medicare expenditures for physicians' services: what are the causes? Inquiry 2004;41:83-94.

AHRQ EPC program Effects of supplemental antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cardiovascular Disease

Shekelle PG, Morton SC, Jungvig LK, Udani J, Spar M, Tu W, J Suttorp M, Coulter I, Newberry SJ, Hardy M. Effect of supplemental antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cardiovascular disease. Evid Rep Technol Assess (Summ). 2003 Jun; (83):1-3.

Shekelle PG, Morton SC, Jungvig LK, Udani J, Spar M, Tu W, J Suttorp M, Coulter I, Newberry SJ, Hardy M. Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. J Gen Intern Med 2004;19:380-389.

AHRQ EPC program Pharmacological management of heart failure and left ventricular systolic dysfunction: effect in female, black, and diabetic patients and cost-effectiveness

Shekelle, PG, Morton S, Atkinson S, Suttorp M, Tu W, Heidenreich P, Gubens M, Maglione M, Jungvig L, Roth E, Newberry S. Pharmacologic Management of Heart Failure and Left Ventricular Systolic Dysfunction: Effect in Female, Black, and Diabetic Patients and Cost-Effectiveness. Evidence Report/Technology Assessment No. 82 (Prepared by the Southern California Evidence-based Practice Center, under Contract No. 290-97-0001). AHRQ Publication Number 03-E045. Rockville MD. Agency for Healthcare Research and Quality. July 2003.

Shekelle PG, Rich MW, Morton SC, Atkinson CS, Tu W, Maglione M, Rhodes S, Barrett M, Fonarow GC, Greenberg B, Heidenreich PA, Knabel T, Konstam MA, Steimle A, Warner Stevenson L. Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction according to race, gender, and diabetic status: a meta-analysis of major clinical trials. J Am Coll Cardiol 2003;41:1529-1538.

Heidenreich PA, Gubens MA, Fonarow GC, Konstam MA, Stevenson LW, Shekelle PG. Cost-effectiveness of screening with B-type natriuretic peptide to identify patients with reduced left ventricular ejection fraction. J Am Coll Cardiol 2004;43:1019-1026.

2003

Funding Agency Project Topic Journal Articles and Evidence Reports
Merck Non-steroidal anti-inflammatory drugs

Ofman, J. J.; MacLean, C. H.; Straus, W. L.; S. C. Morton, S. C.; Berger, M. L.; Roth, E. A., and Shekelle, P. A metaanalysis of severe upper gastrointestinal complications of nonsteroidal anti-inflammatory drugs. J Rheumatol. 2002 Apr; 29(4):804-12.

Straus, W. L.; Ofman, J. J.; MacLean, C.; Morton, S.; Berger, M. L.; Roth, E. A., and Shekelle, P. Do NSAIDs cause dyspepsia? A meta-analysis evaluating alternative dyspepsia definitions. Am J Gastroenterol. 2002 Aug; 97(8):1951-8.

MacLean, C. H.; Morton, S. C.; Ofman, J. J.; Roth, E. A., and Shekelle, P. G. How useful are unpublished data from the Food and Drug Administration in meta-analysis? J Clin Epidemiol. 2003 Jan; 56(1):44-51.

Ofman, J. J.; MacLean, C. H.; Straus, W. L.; Morton, S. C.; Berger, M. L.; Roth, E. A., and Shekelle, P. G. Meta-analysis of dyspepsia and nonsteroidal anti-inflammatory drugs. Arthritis Rheum. 2003 Aug 15; 49(4):508-18.

Cochrane Spinal Manipulation Therapy Assendelft, W. J.; Morton, S. C.; Yu, E. I.; Suttorp, M. J., and Shekelle, P. G. Spinal manipulative therapy for low back pain. A meta-analysis of effectiveness relative to other therapies. Ann Intern Med. 2003 Jun 3; 138(11):871-81.
AHRQ EPC program Best-Case Series for the Use of Immuno-Augmentation Therapy and Naltrexone for the Treatment of Cancer Shekelle P, Coulter I, Hardy ML, Morton SC, Favreau JT, Gagne J, Coulter SA, Udani J, Roth EA, Jungvig LK, Newberry S, Rohr L, Ramirez LR. Best-case series for the use of immuno-augmentation therapy and naltrexone for the treatment of cancer. Evid Rep Technol Assess (Summ) 2003 Apr; (78):2p.
AHRQ EPC program Natural History, Diagnosis, and Late Effects of Otitis Media with Effusion

Takata GS, Chan LS, Mangione-Smith R, Corley P, Morphew T, Morton S, Shekelle PG. Diagnosis, Natural History, and Late Effects of Otitis Media with Effusion. Evidence Report/Technology Assessment No. 55 (Prepared by the Southern California Evidence-based Practice Center, under Contract No. 290-97-0001). AHRQ Publication Number 02-E026. Rockville MD. Agency for Healthcare Research and Quality. June 2002.

Takata GS, Chan LS, Morphew T, Mangione-Smith R, Morton SC, Shekelle P. Evidence assessment of the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion. Pediatrics 2003;112(6 Pt 1):1379-1387.

AHRQ EPC program S-Adenosyl-L-Methionine (SAMe) for Depression, Osteoarthritis, and Liver Disease Hardy ML, Coulter I, Morton SC, Favreau J, Venuturupalli S, Chiappelli F, Rossi F, Orshansky G, Jungvig LK, Roth EA, Suttorp MJ, Shekelle P. S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Evid Rep Technol Assess (Summ) 2003;64:1-3.
CMS Health Risk Appraisals and Medicare Shekelle P, Tucker JS, Maglione M, Morton SC, Roth E, Chao B, Rhodes S, Wu SY, Newberry S, Gruman J, Rubenstein L, Lapin P. Health Risk Appraisals and Medicare. Evidence Report prepared for the US Department of Health and Human Services, Health Care Financing Administration, 7500 Security Blvd., Baltimore MD. 21244-1850, Contract No. 500-98-0281. 2003.
CMS Physical Activity Shekelle P, Maglione M, Mojica W, Morton S, Suttorp M, Tu W, Roth E, Jungvig L, Rhodes S, Wu S, Rubenstein L. Exercise Programs for Older Adults: A Systematic Review and Meta-analysis. Evidence Report prepared for the US Department of Health and Human Services, Centers for Medicare and Medicaid Services, 7500 Security Blvd., Baltimore MD. 21244-1850, Contract No. 500-98-0281.

2002

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program Current Validity of AHRQ Clinical Practice Guidelines

Ortiz O, Eccles M, Grimshaw J, Woolf S. Current validity of clinical practice guidelines. Technical Review 6 (Contract No. 290-97-0001 to the Southern California Evidence-based Practice Center at RAND). AHRQ Publication No. 02-0035. Rockville (MD): Agency for Healthcare Research and Quality. September 2002.

Hasenfeld R, Shekelle PG. Is the methodological quality of guidelines declining in the US? Comparison of the quality of US Agency for Health Care Policy and Research (AHCPR) guidelines with those published subsequently. Qual Saf Health Care 2003;12:428-434.

Shekelle PG, Ortiz E, Rhodes S, Morton SC, Eccles MP, Grimshaw JM, Woolf SH. Validity of the Agency for Healthcare Research and Quality clinical practice guidelines: how quickly do guidelines become outdated? JAMA 2001;286:1461-1467.

Shekelle P, Eccles MP, Grimshaw JM, Woolf SH. When should clinical guidelines be updated? BMJ 2001; 323(7305):155-157.

CMS Interventions that Increase the Utilization of Medicare-Funded Preventive Services for Persons Age 65 and Older

Shekelle P, Stone E, Maglione M, Hirt M, Mojica W, Srikanthan P, Tomizawa T, Morton S, Chao B, Roth E, and Breuder T. Interventions that increase the utilization of Medicare-funded preventive services for persons age 65 and older. Evidence Report prepared for the US Department of Health and Human Services, Health Care Financing Administration, 7500 Security Blvd., Baltimore MD. 21244-1850, Contract No. 500-98-0281.

Stone, E. G.; Morton, S. C.; Hulscher, M. E.; Maglione, M. A.; Roth, E. A.; Grimshaw, J. M.; Mittman, B. S.; Rubenstein, L. V.; Rubenstein, L. Z., and Shekelle, P. G. Interventions that increase use of adult immunization and cancer screening services: a meta-analysis. Ann Intern Med. 2002 May 7; 136(9):641-51.

Maglione, M. A.; Stone, E. G., and Shekelle, P. G. Mass mailings have little effect on utilization of influenza vaccine among Medicare beneficiaries. Am J Prev Med. 2002 Jul; 23(1):43-6.

AHRQ EPC program Mind-Body Interventions for Gastrointestinal Conditions

Coulter ID, Hardy ML, Favreau JT, Elfenbaum PD, Morton SC, Roth EA, Genovese BJ, Shekelle PG. Mind-body interventions for gastrointestinal conditions. Evidence Report/Technology Assessment Report No. 40. Agency For Healthcare Research And Quality, Rockville, MD, Publication No.01-E030, July 2001.

Coulter ID, Favreau JT, Hardy ML, Morton SC, Roth EA, Shekelle P. Biofeedback interventions for gastrointestinal conditions: a systematic review. Altern Ther Health Med. 2002 May-2002 Jun 30; 8(3):76-83.

AHRQ EPC program Prevention and Management of Urinary Tract Infections in Paralyzed Persons

Vickrey B, Shekelle P, Morton S, Clark K, Pathak M, Kamberg C. Prevention and Management of Urinary Tract Infections in Paralyzed Persons. Evidence Report/Technology Assessment No. 6 (Prepared by the Southern California Evidence-based Practice Center, under Contract No. 290-97-0001). AHRQ Publication Number 99-E008. Rockville MD. Agency for Healthcare Research and Quality. February 1999.

Shekelle PG, Morton SC, Clark KA, Pathak M, Vickrey BG. Systematic review of risk factors for urinary tract infection in adults with spinal cord dysfunction. J Spinal Cord Med 1999;22:258-272.

Morton SC, Shekelle PG, Adams JL, Bennett C, Dobkin BH, Montgomerie J, Vickrey BG. Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction. Arch Phys Med Rehabil 2002;83:129-138.

2001

Funding Agency Project Topic Journal Articles and Evidence Reports
AHRQ EPC program Management of Acute Otitis Media

Marcy M, Takata G, Chan L, Shekelle P, Mason W, Wachsman L, Ernst R, Hay J, Corley P, Morphew T, Ramicone E, Nicholson C. Management of Acute Otitis Media. Evidence Report/Technology Assessment No. 15 (Prepared by the Southern California Evidence-based Practice Center, under Contract No. 290-97-0001). AHRQ Publication Number 01-E010. Rockville MD. Agency for Healthcare Research and Quality. May 2001.

Takata GS, Chan LS, Shekelle P, Morton SC, Mason W, Marcy SM. Evidence assessment of management of acute otitis media: I. The role of antibiotics in treatment of uncomplicated acute otitis media. Pediatrics 2001;108:239-247.

Chan LS, Takata GS, Shekelle P, Morton SC, Mason W, Marcy SM. Evidence assessment of management of acute otitis media: II. Research gaps and priorities for future research. Pediatrics 2001;108:248-254.

2000

Funding Agency Project Topic Journal Articles and Evidence Reports
National Kidney Foundation Nutrition in Chronic Kidney Failure Shekelle P, Stone E, Kania S, Weingarten S, Snape M, Hirt M, Tomizawa T, Dorn G, Simone L. Nutrition in Chronic Renal Failure. Prepared for the Kidney Foundation. May 2000.
AHRQ EPC program Venous Thromboem-bolism, Prevention After Injury

Velmahos GC, Kern J, Chan L, Oder D, Murray JA, Shekelle P. Prevention of venous thromboembolism after injury. Evid Rep Technol Assess (Summ) 2000;22:1-3.

http://archive.ahrq.gov/clinic/epcsums/vtsumm.htm

Velmahos GC, Kern J, Chan LS, Oder D, Murray JA, Shekelle P. Prevention of venous thromboembolism after injury: an evidence-based report–part I: analysis of risk factors and evaluation of the role of vena caval filters. J Trauma 2000;49:132-138; discussion 139.

Velmahos GC, Kern J, Chan LS, Oder D, Murray JA, Shekelle P. Prevention of venous thromboembolism after injury: an evidence-based report–part II: analysis of risk factors and evaluation of the role of vena caval filters. J Trauma 2000;49:140-144.

Velmahos GC, Oh Y, McCombs J, Oder D. An evidence-based cost-effectiveness model on methods of prevention of posttraumatic venous thromboembolism. J Trauma 2000;49:1059-1064.