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Carcinoma

Journal Article
Black-White Disparities in Colorectal Cancer Outcomes: A Simulation Study of Screening Benefit
This paper compares projected colorectal cancer (CRC) screening benefits for Black and White populations in the context of secular changes in CRC risk, shifts in CRC location, and Black?White disparities in CRC-specific and overall survival.
Nov 13, 2023
Journal Article
Differences in Lymphoma Patients Between Chimeric Antigen Receptor T-cell Therapy Trials and the General Population
Effectiveness of CAR-T therapies in the general population of lymphoma patients may differ from effectiveness demonstrated in trials.
Nov 6, 2023
Journal Article
Expert Consensus-Based Guidance on Approaches to Opioid Management in Individuals with Advanced Cancer-Related Pain and Nonmedical Stimulant Use
Palliative care and addiction experts considered continuing opioids, increasing monitoring, and avoiding opioid tapering in the context of cancer-related pain and nonmedical stimulant use to be appropriate.
Sep 13, 2023
Journal Article
A Health Profile of African Immigrant Men in the United States
African immigrants (AI) are the fastest growing group of immigrants to the U.S. however, their health and health practices remains poorly characterized. This study aimed to describe their health profile.
Sep 13, 2023
Journal Article
NordICC Trial Results in Line with Expected Colorectal Cancer Mortality Reduction After Colonoscopy: A Modelling Study
This paper uses three Cancer Intervention and Surveillance Modeling Network (CISNET) colorectal cancer models to simulate NordICC trial outcomes.
Jul 21, 2023
Journal Article
Social Determinants of Health and US Cancer Screening Interventions: A Systematic Review
This systematic review of US-based breast, cervical, colorectal, and lung cancer screening intervention studies summarizes how social determinants of health (SDOH) have been considered in interventions and links between SDOH and screening outcomes.
Jul 19, 2023
Journal Article
Evaluation of Approaches to Recruitment of Racially and Ethnically Diverse Breast Cancer Patients from an Integrated Health Care Setting for Collection of Observational Social Network Data
We compared approaches to recruitment of diverse women with breast cancer in a study of social networks. Mailed letter was the best approach to recruit diverse women with breast cancer and collection of social network data.
Jun 14, 2023
Journal Article
Projected Long-Term Effects of Colorectal Cancer Screening Disruptions Following the COVID-19 Pandemic
This comparative analysis uses two CISNET colorectal cancer (CRC) microsimulation models to assess the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes.
May 5, 2023
Commentary
Advancing Women's Health Requires Better Evidence
For decades, advances in health and health care have had a bias toward the male body. By shifting the focus of research to women's bodies and building out this base of evidence on women's health, scientists and doctors can improve health outcomes and overall quality of life for women, all while also saving money.
Apr 10, 2023
Journal Article
Cost-Effectiveness Analysis of CAR T-Cell Therapies Vs Antibody Drug Conjugates for Patients with Advanced Multiple Myeloma
In this analysis, we built a Monte Carlo Markov Chain microsimulation model using estimates and parameters from the evidence on standard treatment for multiple myeloma and chimeric antigen receptor T-cell therapies.
Jan 25, 2023
Dissertation
Robust Decision Making in Health Policy: Applications to COVID-19 and Colorectal Cancer
Presents three papers exploring the utility of Robust Decision Making for supporting health policy decisions.
Dec 22, 2022
Report
Societal Impact of Research Funding for Women's Health in Lung Cancer
The authors find that small investments are likely to yield large gains from increasing research funding in lung cancer; investing in women's health research yields benefits above investing in general research.
Nov 1, 2022
Journal Article
Consensus-Based Guidance on Opioid Management in Individuals With Advanced Cancer-Related Pain and Opioid Misuse or Use Disorder
This qualitative study provides consensus-based guidance for clinicians and highlights research and policy gaps that warrant urgent attention to meet the needs of people with cancer-related pain and opioid misuse/use disorder.
Sep 21, 2022
Journal Article
Enhancing Access to and Diversity in Cancer Clinical Trials Through a Financial Reimbursement Program: Protocol to Evaluate a Novel Program
We implemented a financial reimbursement and outreach program designed to increase the number and diversity of participants in cancer clinical trials at centers in Dallas, Houston, and Philadelphia.
Sep 15, 2022
Journal Article
Barriers to Chimeric Antigen Receptor T-Cell (CAR-T) Therapies in Clinical Practice
The barriers to the use of CAR-T therapy include complex logistics, manufacturing limitations, toxicity concerns, and financial burden. This review discusses solutions to overcome these barriers to make this therapy widely accessible.
Sep 15, 2022
Journal Article
Cost Effectiveness of Mailed Outreach Programs for Colorectal Cancer Screening: Analysis of a Pragmatic, Randomized Trial
Clinical guidelines for colorectal cancer (CRC) screening suggest use of either stool-based tests or colonoscopy. We conducted a cost-effectiveness analysis to compare 2 mailed outreach strategies to increase CRC screening.
Sep 15, 2022
Journal Article
Too Good to Be True? Evaluation of Colonoscopy Sensitivity Assumptions Used in Policy Models
This paper examines the validity of the CRC-SPIN model and colonoscopy sensitivity assumptions. We find that colonoscopy may be less accurate than currently assumed, especially for diminutive adenomas.
Aug 17, 2022
Journal Article
Cost-Effectiveness of Community-to-Clinic Tailored Navigation for Colorectal Cancer Screening in an Underserved Population: Economic Evaluation Alongside a Group-Randomized Trial
Adding community-to-clinic tailored navigation to a community-based colorectal cancer screening promotion program may be highly cost-effective.
May 13, 2022
Journal Article
Expert Panel Consensus on Management of Advanced Cancer-Related Pain in Individuals With Opioid Use Disorder
We engaged experts using an online modified Delphi approach to develop consensus on the appropriateness of strategies for managing cancer pain in individuals with co-occurring advanced cancer and opioid use disorder.
Jan 4, 2022
Commentary
What Are the Practical Considerations for Outcome-Based Payment in the NHS?
Uncertainty can surround the effectiveness or cost-effectiveness of a new medicine, making it difficult to agree on a medicine's price. One solution to avoid unduly delaying or restricting patients' access is to link the medicine's price to the outcomes it produces in a patient. Despite some barriers, outcome-based payment could offer a “win” for patients, the NHS, and industry.
Dec 2, 2021

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RAND Topic:
Cancer

Topic Synonyms:
Carcinoma;
Neoplasms;
Oncology;
Sarcoma

Research conducted by

RAND Health Care

Researcher Spotlight

Mark Cabling

Analyst

Mark Cabling is an analyst at RAND Europe in health and wellbeing, working on health care innovation research. He works on projects that involve rapid evidence assessments for clients such as Sanofi and Merck Europe, exploring the indirect burden of seasonal influenza and R&D cost transparency,…
Ashlyn Tom

Policy Analyst

Ashlyn Tom is a policy analyst at the RAND Corporation. She has dedicated her career to conducting research aimed at improving the delivery of health care. She currently supports and manages several projects assessing health care performance, evaluating physician incentives, and promoting health…

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