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Genetics

Recent breakthroughs in genetics have the potential to significantly improve health outcomes. RAND research examines the impact of genetics on personal and public health, disease prevention, diagnosis, and treatment.

News Release

The Structural Genomics Consortium, an Innovative Open-Access, Public–Private Partnership, Is a Viable Model for Drug ...

The Structural Genomics Consortium is a viable model for drug discovery that appeals to investors, not least for advantages in efficiency over current models of public or commercial health research.

Mar 10, 2014
Report

Structural Genomics Consortium Offers Knowledge Platform for Drug Discovery

An independent evaluation of the Structural Genomics Consortium (SGC) examined the strengths and weaknesses of its efforts to support drug discovery efforts through a unique, open access model of public-private collaboration.

Mar 10, 2014
Report

The Structural Genomics Consortium: A knowledge platform for drug discovery: A summary

This report summarises the results of an independent evaluation of the Structural Genomics Consortium, an open access model of public-private collaboration, conducted by RAND Europe with the Institute on Governance.

Mar 10, 2014
Journal Article

The Value of Diagnostic Testing in Personalized Medicine

A framework derived from information economics for assessing the value of diagnostics demonstrates that the social value of such diagnostics can be very large, both by avoiding unnecessary treatment and by identifying patients who otherwise would not get treated.

Jun 1, 2013
Journal Article

Effective Communication of Molecular Genetic Test Results

Using a template for molecular genetic test reports, developed to reduce communication errors between the laboratory and ordering clinician, was found to improve physician ratings compared to standard laboratory templates—especially with doctors who were least familiar with the reports.

Dec 6, 2012
Commentary

What Will Change Most About Our Routine Physicals Over the Next Decade?

Don't forget—an American's odds of living a long and healthy life still depend more on his zip code than his genetic code. That won't change until we make healthcare more affordable, writes Dr. Arthur Kellermann.

Aug 31, 2012
Journal Article

A Report Template for Molecular Genetic Tests Designed to Improve Communication Between the Clinician and Laboratory

With input from key stakeholders and building upon prior work, we created a template for molecular genetic test reports designed to improve clinical decision making at the point of care.

Jul 16, 2012
Journal Article

Diagnostics as Essential Tools for Containing Antibacterial Resistance

Appropriate use of existing diagnostic tests for infections, and development of better ones, could reduce overuse of antibacterial drugs.

Apr 1, 2011
Journal Article

Population Prevalence of Familial Cancer and Common Hereditary Cancer Syndromes: The 2005 California Health Interview Survey

We provide population-based prevalence estimates for moderate and strong familial risk for five common cancers and hereditary breast-ovarian cancer and hereditary nonpolyposis colon cancer.

Nov 1, 2010
Journal Article

Are Electronic Health Records Ready for Genomic Medicine?

The goal of this project was to assess genetic/genomic content in electronic health records.

Jul 1, 2009
Research Brief

Delivery of Genomic Medicine for Common Chronic Adult Diseases

This fact sheet summarizes recommendations for health care workers, consumers, and the scientific community to prepare the health care system for genomic medicine for common chronic diseases.

Apr 2, 2008
News Release

Health Professionals and the Public Unprepared to Make Use of Genomic Medicine for Adults

Although advances in genomic medicine for common adult chronic diseases such as heart disease, diabetes, and cancer hold promise for improved prevention, diagnosis and treatment, health professionals and the public are not prepared to effectively integrate these new tools into practice.

Mar 18, 2008
Journal Article

Relation of Familial Patterns of Coronary Heart Disease, Stroke, and Diabetes to Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis

Investigate the possibility that family history beyond early-onset coronary heart disease might contribute to coronary heart disease susceptibility, the authors studied associations between additional family history and the coronary artery calcium score.

Jan 1, 2008
Journal Article

Health Professionals and the Public Unprepared to Make Use of Genomic Medicine for Adults

Although advances in genomic medicine for common adult chronic diseases such as heart disease, diabetes, and cancer hold promise for improved prevention, diagnosis and treatment, health professionals and the public are not prepared to effectively integrate these new tools into practice.

Jan 1, 2008
Journal Article

Haplotypes in the Lipoprotein Lipase Gene Influence High-Density Lipoprotein Cholesterol Response to Statin Therapy and Progression of Atherosclerosis in Coronary Artery Bypass Grafts

Lipoprotein lipase hydrolyzes circulating triglycerides. 3'-end haplotypes in the LPL gene influence atherosclerosis and insulin resistance.

Feb 1, 2007
Journal Article

Repeated Measures Analyses of Dose Timing of Antiretroviral Medication and Its Relationship to HIV Virologic Outcomes

Medication adherence is a critical predictor of the effectiveness of antiretroviral medications in the treatment of HIV/AIDS.

Jan 1, 2007
Journal Article

Efficacy of Angiotensin-Converting Enzyme Inhibitors and Beta-Blockers in the Management of Left Ventricular Systolic Dysfunction According to Race, Gender and Diabetic Status: A Meta-Analysis of Major Clinical Trials

Women with asymptomatic LV systolic dysfunction may not achieve a mortality benefit when treated with ACE inhibitors.

Jan 1, 2003
Journal Article

Genomic Medicine: The Sorcerer's New Broom? the Limitations of the Human Genome Project

The author warns that genomic medicine runs the risk of diverting the attention of medicine away from what the public and its critics have been saying

Jan 1, 2001
Report

A Preliminary Model of Double-Minute-Mediated Gene Amplification

Develops a mathematical model of double minute (dm) population dynamics based on current concepts of the saltatory replication, random partitioning, nuclear exclusion and loss, and cellular growth inhibition of these extrachromosomal elements.

Apr 1, 1983
People

Andrea Richardson

Policy Researcher; Professor, Pardee RAND Graduate School
Education Ph.D. in nutrition epidemiology, University of North Carolina at Chapel Hill; M.P.H. in epidemiology, Emory University; B.S. in math, University of Chicago

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