2021-03-23T19:26:35Z Copyright (c) 2021, The RAND Corporation RAND Corporation https://www.rand.org/topics/genetics.html Benjamin M. Miller; David Metz; Jon Schmid; Paige M. Rudin; Marjory S. Blumenthal https://www.rand.org/pubs/research_reports/RRA838-1.html 2021-02-11T00:01:00Z 2021-02-11T00:01:00Z

Inventions help people around the world live longer, healthier, and more-productive lives. The inventions of Lemelson-MIT Prize winners illustrate the scientific, technological, economic, and social effects that inventions can have on society.

Sarah Parkinson; Joe Francombe; Cagla Stevenson; Hamish Evans; Advait Deshpande; Susan Guthrie https://www.rand.org/pubs/research_reports/RRA215-1.html 2021-01-19T19:00:00Z 2021-01-19T19:00:00Z

RAND Europe was commissioned by Wellcome to analyse the role and contribution of the Sanger Institute and the Wellcome Genome Campus within the field of genetics and genomics, set within the context of four comparator organisations.

Anna Middleton; Richard Milne; Mohamed A. Almarri; Shamim Anwer; Jerome Atutornu; Elena E. Baranova; Paul Bevan; Maria Cerezo; Yali Cong; Christine Critchley; Josepine Fernow; Peter Goodhand; Qurratulain Hasan; Aiko Hibino; Gry Houeland; Heidi Howard; S. Zakir Hussain; Charlotta Ingvoldstad Malmgren; Vera L. Izhevskaya; Aleksandra Jedrzejak; Cao Jinhong; Megumi Kimura; Erika Kleiderman; Brandi Leach; Keying Liu; Deborah Mascalzoni; Álvaro Mendes; Jusaku Minari; Nan Wang; Dianne Nicol; Emilia Niemiec; Christine Patch; Jack Pollard; Barbara Prainsack; Marie Rivière; Lauren Robarts; Jonathan Roberts; Virginia Romano; Haytham A. Sheerah; James P. Smith; Alexandra Soulier; Claire Steed; Vigdís Stefànsdóttir; Cornelia Tandre; Adrian Thorogood; Torsten H. Voigt; Anne V. West; Go Yoshizawa; Katherine I. Morley https://www.rand.org/pubs/external_publications/EP68288.html 2020-09-22T11:00:00Z 2020-09-22T11:00:00Z

Analyzing genomic data across populations is central to understanding the role of genetic factors in health and disease. This paper presents results from a very large public survey on attitudes toward genomic data sharing.

Richard Milne; Katherine I. Morley; Heidi Howard; Emilia Niemiec; Dianne Nicol; Christine Critchley; Barbara Prainsack; Danya Vears; James P. Smith; Claire Steed; Paul Bevan; Jerome Atutornu; Lauren Farley; Peter Goodhand; Adrian Thorogood; Erika Kleiderman; Anna Middleton https://www.rand.org/pubs/external_publications/EP67974.html 2019-10-10T09:30:00Z 2019-10-10T09:30:00Z

Trust may be important in shaping public attitudes to genetics and intentions to participate in genomics research and big data initiatives. This study examined trust in data sharing among the general public in the USA, Canada, UK and Australia.

Tepring Piquado; Carl F. Matthies; Lucy Strang; James M. Anderson https://www.rand.org/pubs/research_reports/RR3209.html 2019-08-12T09:00:00Z 2019-08-12T09:00:00Z

Forensic DNA databases help solve crimes. When an exact DNA match is not found, familial DNA and moderate stringency search may provide investigative leads. Evidence-based practices can guide policymakers on the use and effectiveness of this method.

Tepring Piquado; Carl F. Matthies; Lucy Strang; James M. Anderson https://www.rand.org/pubs/tools/TL343.html 2019-08-12T09:00:00Z 2019-08-12T09:00:00Z

This tool shows criminal justice policymakers how state policies affect the size and racial composition of forensic DNA databases. Users can view current state policies or change inputs and assumptions to see how database composition is impacted.

Dmitry Khodyakov; Elizabeth Bromley; Sandra Kay Evans; Katharine Sieck https://www.rand.org/pubs/research_reports/RR2578.html 2018-08-17T12:10:00Z 2018-08-17T12:10:00Z

RAND researchers identified best practices for engaging participants in the All of Us Research Program, which collects long-term health data from 1 million U.S. adults. Engagement involves awareness, enrollment, and retention of program participants.

Krisztina Mekli; Drystan Phillips; Thalida E. Arpawong; Bram Vanhoutte; Gindo Tampubolon; James Nazroo; Jinkook Lee; Carol A. Prescott; Adam Stevens; Neil Pendleton https://www.rand.org/pubs/external_publications/EP67559.html 2018-04-17T12:00:00Z 2018-04-17T12:00:00Z

This exploration of genomic associations with depression found no compelling evidence of a single genetic variant's significant role in depressive symptomatology.

Misa Graff; Kari E. North; Andrea Richardson; Kristin L. Young; A. L. Mazul; Heather Highland; Karen L. Mohlke; Leslie A. Lange; Ethan M. Lange; Kathleen Mullan Harris; Penny Gordon-Larsen https://www.rand.org/pubs/external_publications/EP67050.html 2017-03-14T17:30:00Z 2017-03-14T17:30:00Z

Several established BMI genetic variants are positively associated with change in BMI during the period of adolescence and young adulthood.

Stacy W. Gray; Benjamin Kim; Lynette Sholl; Angel Cronin; Aparna R. Parikh; Carrie N. Klabunde; Katherine L. Kahn; David Haggstrom; Nancy L. Keating https://www.rand.org/pubs/external_publications/EP67024.html 2017-03-13T16:00:00Z 2017-03-13T16:00:00Z

More research is needed to determine whether the observed variation in genomic testing for lung and colorectal cancer reflects appropriate or inappropriate care.

Misa Graff; Andrea Richardson; Kristin L. Young; A. L. Mazul; Heather Highland; Kari E. North; Karen L. Mohlke; Leslie A. Lange; Ethan M. Lange; Katherine M. Harris; Penny Gordon-Larsen https://www.rand.org/pubs/external_publications/EP66715.html 2016-11-15T10:00:00Z 2016-11-15T10:00:00Z

This study of a diverse sample of American adolescents found that neighborhood environmental factors did not appear to influence genetic obesity risk.

Leslie A. Lange; Mariaelisa Graff; Ethan M. Lange; Kristin L. Young; Andrea Richardson; Karen L. Mohlke; Kari E. North; Kathleen Harris; Penny Gordon-Larsen https://www.rand.org/pubs/external_publications/EP66651.html 2016-09-29T10:45:00Z 2016-09-29T10:45:00Z

In young adults with European heritage, a blood marker used to classify type 2 diabetes, HbA1c, was found to be significantly associated with two variants of a genetic region involved in metabolic control, SH2B1.

Talitha Dubow; Sonja Marjanovic https://www.rand.org/pubs/research_reports/RR1520.html 2016-04-29T11:15:00Z 2016-04-29T11:15:00Z

This paper reflects on the variety and evolution of population-scale genome-sequencing initiatives, examining their diverse aims, activities, management and governance approaches, impacts, and policy and research implications.

Thalida E. Arpawong; Jinkook Lee; Drystan Phillips; Eileen Crimmins; Morgan E. Levine; Carol A. Prescott https://www.rand.org/pubs/external_publications/EP66354.html 2016-02-29T13:45:00Z 2016-02-29T13:45:00Z

Depending on genetic sensitivity to it, stress may affect depressive symptomatology differentially.

Kasey G. Creswell; Aidan G. Wright; Wendy M. Troxel; Robert E. Ferrell; Janine D. Flory; Stephen B. Manuck https://www.rand.org/pubs/external_publications/EP50574.html 2015-01-12T12:00:00Z 2015-01-12T12:00:00Z

Humans have a fundamental need for strong interpersonal bonds, yet individuals differ appreciably in their degree of social integration.

Patricia Boyle https://www.rand.org/pubs/presentations/PT132.html 2014-09-08T09:15:00Z 2014-09-08T09:15:00Z

Session from the 21st Annual RAND Summer Institute, held July 7-11, 2014, in Santa Monica, CA, addressing critical issues facing our aging population.

Molly Morgan Jones; Sophie Castle-Clarke; Daniel Brooker; Edward Nason; Farah Huzair; Joanna Chataway https://www.rand.org/pubs/research_reports/RR512.html 2014-03-10T19:49:01Z 2014-03-10T19:49:01Z

An independent evaluation of the Structural Genomics Consortium (SGC) examined the strengths and weaknesses of its efforts to support drug discovery efforts through a unique, open access model of public-private collaboration.

RAND Corporation https://www.rand.org/news/press/2014/03/10/index1.html 2014-03-10T13:58:00Z 2014-03-10T13:58:00Z

The Structural Genomics Consortium is a viable model for drug discovery that appeals to investors, not least for advantages in efficiency over current models of public or commercial health research.

Molly Morgan Jones; Sophie Castle-Clarke; Daniel Brooker; Edward Nason; Farah Huzair; Joanna Chataway https://www.rand.org/pubs/research_reports/RR512z1.html 2014-03-10T12:30:00Z 2014-03-10T12:30:00Z

This report summarises the results of an independent evaluation of the Structural Genomics Consortium, an open access model of public-private collaboration, conducted by RAND Europe with the Institute on Governance.

Dana P. Goldman; Charu Gupta; Eshan Vasudeva; Kostas Trakas; Ralph Riley; Darius N. Lakdawalla; David Agus; Neeraj Sood; Anupam B. Jena; Tomas Philipson https://www.rand.org/pubs/external_publications/EP51572.html 2013-06-01T13:08:00Z 2013-06-01T13:08:00Z

A framework derived from information economics for assessing the value of diagnostics demonstrates that the social value of such diagnostics can be very large, both by avoiding unnecessary treatment and by identifying patients who otherwise would not get treated.