The authors find that small investments are likely to yield large gains from increasing research funding in lung cancer; investing in women's health research yields benefits above investing in general research.
This qualitative study provides consensus-based guidance for clinicians and highlights research and policy gaps that warrant urgent attention to meet the needs of people with cancer-related pain and opioid misuse/use disorder.
The barriers to the use of CAR-T therapy include complex logistics, manufacturing limitations, toxicity concerns, and financial burden. This review discusses solutions to overcome these barriers to make this therapy widely accessible.
Clinical guidelines for colorectal cancer (CRC) screening suggest use of either stool-based tests or colonoscopy. We conducted a cost-effectiveness analysis to compare 2 mailed outreach strategies to increase CRC screening.
This paper examines the validity of the CRC-SPIN model and colonoscopy sensitivity assumptions. We find that colonoscopy may be less accurate than currently assumed, especially for diminutive adenomas.
We engaged experts using an online modified Delphi approach to develop consensus on the appropriateness of strategies for managing cancer pain in individuals with co-occurring advanced cancer and opioid use disorder.
Uncertainty can surround the effectiveness or cost-effectiveness of a new medicine, making it difficult to agree on a medicine's price. One solution to avoid unduly delaying or restricting patients' access is to link the medicine's price to the outcomes it produces in a patient. Despite some barriers, outcome-based payment could offer a “win” for patients, the NHS, and industry.
This study examines implementing an outcome-based payment model in the NHS, the quality and completeness of data on patient outcomes, implications for collecting such data, and establishing steps for the implementation of a pilot OBP scheme.
Chimeric antigen receptor (CAR)-T-cell therapy appears to be a promising treatment for B-cell and non-Hodgkin's lymphoma. CAR-T therapy effectiveness in the general population of patients may differ from effectiveness demonstrated in trials.
Higher rates of colorectal cancer incidence among black patients are primarily driven by lower rates of colorectal cancer screening. Our findings highlight the need to increase black patients' access to quality screening to reduce colorectal cancer incidence and mortality.
Screenings for breast cancer and colon cancer dropped dramatically during the early months of the coronavirus pandemic, but use of the procedures returned to near-normal levels by the end of July 2020.
Opportunities exist to improve hospice care for symptom palliation and training for caregivers when their family members are at home or in an ALF setting. Efforts to improve care for cancer patients in the NH and ALF setting are especially needed.
This study aimed to describe strategies CHCs use to integrate care with specialists and examine whether more strongly integrated CHCs have higher rates of screening for colorectal and cervical cancers and report better communication with specialists.
Cancer is a leading cause of death in the UK. Action is needed now to recruit and train more NHS staff in certain key cancer-related roles if NHS is to meet its ambitions for improving cancer services over the next 10 years.
Several public cord blood banks are struggling financially, and the question remains whether additional allocations of funds to them are justified. This article estimates the social benefits of public cord blood bank inventory net of cord blood banks' operational costs.