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Oncology

Journal Article
Cost-Effectiveness Analysis of CAR T-Cell Therapies Vs Antibody Drug Conjugates for Patients with Advanced Multiple Myeloma
In this analysis, we built a Monte Carlo Markov Chain microsimulation model using estimates and parameters from the evidence on standard treatment for multiple myeloma and chimeric antigen receptor T-cell therapies.
Jan 25, 2023
Dissertation
Robust Decision Making in Health Policy: Applications to COVID-19 and Colorectal Cancer
Presents three papers exploring the utility of Robust Decision Making for supporting health policy decisions.
Dec 22, 2022
Report
Societal Impact of Research Funding for Women's Health in Lung Cancer
The authors find that small investments are likely to yield large gains from increasing research funding in lung cancer; investing in women's health research yields benefits above investing in general research.
Nov 1, 2022
Journal Article
Consensus-Based Guidance on Opioid Management in Individuals With Advanced Cancer-Related Pain and Opioid Misuse or Use Disorder
This qualitative study provides consensus-based guidance for clinicians and highlights research and policy gaps that warrant urgent attention to meet the needs of people with cancer-related pain and opioid misuse/use disorder.
Sep 21, 2022
Journal Article
Enhancing Access to and Diversity in Cancer Clinical Trials Through a Financial Reimbursement Program: Protocol to Evaluate a Novel Program
We implemented a financial reimbursement and outreach program designed to increase the number and diversity of participants in cancer clinical trials at centers in Dallas, Houston, and Philadelphia.
Sep 15, 2022
Journal Article
Barriers to Chimeric Antigen Receptor T-Cell (CAR-T) Therapies in Clinical Practice
The barriers to the use of CAR-T therapy include complex logistics, manufacturing limitations, toxicity concerns, and financial burden. This review discusses solutions to overcome these barriers to make this therapy widely accessible.
Sep 15, 2022
Journal Article
Cost Effectiveness of Mailed Outreach Programs for Colorectal Cancer Screening: Analysis of a Pragmatic, Randomized Trial
Clinical guidelines for colorectal cancer (CRC) screening suggest use of either stool-based tests or colonoscopy. We conducted a cost-effectiveness analysis to compare 2 mailed outreach strategies to increase CRC screening.
Sep 15, 2022
Journal Article
Too Good to Be True? Evaluation of Colonoscopy Sensitivity Assumptions Used in Policy Models
This paper examines the validity of the CRC-SPIN model and colonoscopy sensitivity assumptions. We find that colonoscopy may be less accurate than currently assumed, especially for diminutive adenomas.
Aug 17, 2022
Journal Article
Cost-Effectiveness of Community-to-Clinic Tailored Navigation for Colorectal Cancer Screening in an Underserved Population: Economic Evaluation Alongside a Group-Randomized Trial
Adding community-to-clinic tailored navigation to a community-based colorectal cancer screening promotion program may be highly cost-effective.
May 13, 2022
Journal Article
Expert Panel Consensus on Management of Advanced Cancer-Related Pain in Individuals With Opioid Use Disorder
We engaged experts using an online modified Delphi approach to develop consensus on the appropriateness of strategies for managing cancer pain in individuals with co-occurring advanced cancer and opioid use disorder.
Jan 4, 2022
Commentary
What Are the Practical Considerations for Outcome-Based Payment in the NHS?
Uncertainty can surround the effectiveness or cost-effectiveness of a new medicine, making it difficult to agree on a medicine's price. One solution to avoid unduly delaying or restricting patients' access is to link the medicine's price to the outcomes it produces in a patient. Despite some barriers, outcome-based payment could offer a “win” for patients, the NHS, and industry.
Dec 2, 2021
Journal Article
Making Outcome-Based Payment a Reality in the NHS: Phase 2: Practical Considerations
This study examines implementing an outcome-based payment model in the NHS, the quality and completeness of data on patient outcomes, implications for collecting such data, and establishing steps for the implementation of a pilot OBP scheme.
Dec 1, 2021
Journal Article
Narrative Review and Evidence Mapping: Proteomics for Cancer and Cardiovascular Disease
This report presents evidence supporting proteomic tests for cancer and cardiovascular disease currently approved in the United States and proteomic tests that may be available in the near term.
Aug 26, 2021
Journal Article
B-cell Lymphoma and Non-Hodgkin's Lymphoma Treatment: How Do Participants of Chimeric Antigen Receptor T-cell (CAR-T) Therapy Research Studies Compare With Patients in the US Population?
Chimeric antigen receptor (CAR)-T-cell therapy appears to be a promising treatment for B-cell and non-Hodgkin's lymphoma. CAR-T therapy effectiveness in the general population of patients may differ from effectiveness demonstrated in trials.
Jun 17, 2021
Journal Article
Black and White Differences in Colorectal Cancer Screening and Screening Outcomes: A Narrative Review
Higher rates of colorectal cancer incidence among black patients are primarily driven by lower rates of colorectal cancer screening. Our findings highlight the need to increase black patients' access to quality screening to reduce colorectal cancer incidence and mortality.
May 27, 2021
Journal Article
Evidence Map of Ductal Carcinoma in Situ Management Options
This is an evidence-map of ductal carcinoma in situ treatment options and impacts on patient-centered and clinical options.
May 26, 2021
News Release
Use of Common Cancer Screenings Rebounded Quickly After Dropping at Start of the Pandemic
Screenings for breast cancer and colon cancer dropped dramatically during the early months of the coronavirus pandemic, but use of the procedures returned to near-normal levels by the end of July 2020.
Mar 22, 2021
Journal Article
Hospice Care Experiences Among Cancer Patients and Their Caregivers
Opportunities exist to improve hospice care for symptom palliation and training for caregivers when their family members are at home or in an ALF setting. Efforts to improve care for cancer patients in the NH and ALF setting are especially needed.
Feb 26, 2021
Journal Article
Association of Primary and Specialty Care Integration on Physician Communication and Cancer Screening in Safety-Net Clinics
This study aimed to describe strategies CHCs use to integrate care with specialists and examine whether more strongly integrated CHCs have higher rates of screening for colorectal and cervical cancers and report better communication with specialists.
Feb 12, 2021
Journal Article
End-of-Life Cost Trajectories in Cancer Patients Treated by Medicare Versus the Veterans Health Administration
To evaluate differences in end-of-life cost trajectories for cancer patients treated through Medicare versus by the Veterans Health Administration (VA).
Dec 30, 2020

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RAND Topic:
Cancer

Topic Synonyms:
Carcinoma;
Neoplasms;
Oncology;
Sarcoma

Research conducted by

RAND Health Care

Researcher Spotlight

Maria DeYoreo

Codirector, RAND Center for Causal Inference

Maria DeYoreo is a statistician at the RAND Corporation and codirector of the Center for Causal Inference. Her methodological interests include Bayesian modeling, mixed and random effects modeling, Bayesian nonparametrics, missing data imputation, data fusion, and causal inference. DeYoreo's…
Natalie Ernecoff

Associate Policy Researcher

Natalie C. Ernecoff (she/her) is an associate policy researcher at the RAND Corporation. Her research focuses on developing, implementing, and evaluating systems-level palliative care, hospice, and home care interventions. Her work includes healthcare system informatics, electronic health record…

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