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Prescription Drug Abuse

Abuse of prescription painkillers, sedatives, tranquilizers, and stimulants is a rising cause of mortality in developed countries. RAND research examines prescription sharing, prevention efforts, prevalence and risk factors, and opportunities to gauge markets for diverted pharmaceuticals.

Journal Article

The Evolving Consequences of OxyContin Reformulation on Drug Overdoses

In this paper, we find that over a longer time horizon, OxyContin reformulation stimulated illicit drug markets to grow and evolve.

Mar 17, 2021
Journal Article

Multiplying the Impact of Opioid Settlement Funds by Investing in Primary Prevention

In this Perspective, we describe three strategies hospitals can use to multiply the reach of their opioid settlement funding by addressing root causes of opioid use through primary prevention.

Mar 17, 2021
Journal Article

Racial/ethnic Differences in Prescription Opioid Misuse and Heroin Use Among a National Sample, 1999–2018

We compared relative prevalences across 6 racial/ethnic groups for prescription opioid misuse analyses and 4 racial/ethnic groups for heroin analyses.

Feb 19, 2021
Journal Article

Opioid Prescribing History Prior to Heroin Overdose Among Commercially Insured Adults

We used insurance claims to examine the prevalence and prescribing patterns of prescription opioids in a national cohort of individuals experiencing a treated heroin-related overdose between 2010 and 2017.

Jul 31, 2020
Journal Article

The Public Health Value of Opioid Litigation

This article proceeds in three parts: discussions of the general goals and role of public health tort litigation, the demonstrated and potential value of opioid litigation to achieve public health goals, and a conclusion.

Jul 31, 2020
Journal Article

Variation in the Degree of Concentration of Prescription Opioid Utilization Using Different Measures

A small share of prescription opioid users account for a large percent of total prescription opioid use.

Jun 26, 2020
Journal Article

Initial Opioid Prescriptions Among U.S. Commercially Insured Patients, 2012–2017

Our study provides a snapshot of trends in the rate at which opioid therapy was initiated among commercially insured patients during a period of heightened attention to the dangers of opioids and the prominent release of prescribing guidelines by the CDC.

Mar 5, 2020
Journal Article

Heterogeneity in Prescription Opioid Pain Reliever Misuse Across Age Groups: 2015–2017 National Survey on Drug Use and Health

Results demonstrating heterogeneity in prescription opioid misuse characteristics across age groups highlight the need for a diverse range of clinical and policy responses.

Mar 5, 2020
Testimony

Addressing the U.S. Opioid Crisis: Using an Integrated Systems-Based Approach: Addendum

Document submitted January 21, 2020, as an addendum to testimony before the Senate Judiciary Committee Hearing on Opioids on December 17, 2019.

Jan 20, 2020
Multimedia

Addressing the U.S. Opioid Crisis: Using an Integrated Systems-Based Approach

An overview of testimony by Bradley D. Stein presented before the Senate Judiciary Committee on December 17, 2019.

Dec 17, 2019
Testimony

Approaching the U.S. Opioid Crisis as an Ecosystem

Policymakers should think of the opioid crisis as an ecosystem and consider how its many parts interact—especially in unexpected ways. A broader view of the crisis will help those confronting it better prepare for the challenges ahead.

Dec 17, 2019
Journal Article

Reducing High-Dose Opioid Prescribing: State-Level Morphine Equivalent Daily Dose Policies, 2007-2017

Morphine equivalent daily dose thresholds are a promising policy tool, but there is a lack of consensus about how to use the thresholds and what the threshold level should be.

Mar 22, 2019
Journal Article

Physician Prescribing of Opioids to Patients at Increased Risk of Overdose From Benzodiazepine Use in the United States

New opioid prescriptions decreased among higher-risk patients who used benzodiazepines from 2010 to 2015, suggesting that the rapid increase in opioid-related deaths is primarily associated with factors other than physicians writing new opioid prescriptions.

Mar 1, 2019
Journal Article

Unveiling an 'Invisible Population': Health, Substance Use, Sexual Behavior, Culture, and Discrimination Among Urban American Indian/Alaska Native Adolescents in California

American Indian/Alaska Native adolescents in this study used alcohol or other drugs at rates similar to those found in national surveys and rates of risky sexual behavior were also comparable to national data.

Feb 28, 2019
Commentary

Opioids and a Crisis of Unintended Consequences

The pain medicine OxyContin was reformulated in 2010 to make it more difficult to crush or dissolve. But this had unintended consequences, including a rise in hepatitis C infections as drug abusers switched from taking OxyContin to injecting heroin.

Feb 20, 2019
Journal Article

Effect of Age on Opioid Prescribing, Overdose, and Mortality in Massachusetts, 2011 to 2015

Older age was the strongest predictor of undergoing potentially inappropriate prescribing (PIP) among individuals who were prescribed opioids. PIP was also associated with risk of adverse outcomes in both older and younger adults.

Jan 29, 2019
Journal Article

Supply-Side Drug Policy in the Presence of Substitutes: Evidence from the Introduction of Abuse-Deterrent Opioids

The recent increase in heroin deaths is primarily fueled by the reformulation of OxyContin.

Oct 31, 2018
Commentary

In Opioid Policy, One Size Does Not Fit All

To solve America's opioid crisis, policymakers will need to view the epidemic as an “ecosystem,” where policies that target only one part of the problem can have unintended consequences.

Oct 12, 2018
Journal Article

Nearly Thirty Percent of Physicians' Opioid Prescriptions Lack a Pain Diagnosis

Medical use of opioids has increased dramatically over the past two decades, far exceeding increases in the prevalence of pain. No pain diagnosis was recorded at 28.5 percent of physician visits in which an opioid was prescribed.

Sep 14, 2018
Infographic

Managing Pain with Alternative Therapies

About 126 million adults report having pain in the past three months. Alternative and integrative therapies, such as acupuncture, mindfulness (meditation), and Tai Chi, may help some individuals manage their pain. This infographic compiles information from hundreds of reviews of the evidence on the effect of these three therapies on different types of pain.

Aug 24, 2018

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