The Effective Use of Both Positive and Negative Controls in Screening Experiments
Published in: Biometrics: Journal of the International Biometric Society, v. 23, no. 2, June 1967, p. 285-295
Posted on RAND.org on January 01, 1967
In the experimental screening of anti-cancer agents, it is common to employ two control groups. These are, an untreated negative control group, and a group treated with standard effective agent, the positive control group. In this paper the problems of animal allocation to the two control groups and estimation of drug effects, taking data for both groups into account, are considered using a minimum variance criterion. The rationale for the use of both types is discussed.