The Effective Use of Both Positive and Negative Controls in Screening Experiments

Published in: Biometrics: Journal of the International Biometric Society, v. 23, no. 2, June 1967, p. 285-295

Posted on RAND.org on January 01, 1967

by Nathan Mantel

Read More

Access further information on this document at tibs.org

This article was published outside of RAND. The full text of the article can be found at the link above.

In the experimental screening of anti-cancer agents, it is common to employ two control groups. These are, an untreated negative control group, and a group treated with standard effective agent, the positive control group. In this paper the problems of animal allocation to the two control groups and estimation of drug effects, taking data for both groups into account, are considered using a minimum variance criterion. The rationale for the use of both types is discussed.

This report is part of the RAND Corporation external publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.