A Survey of Current Problems in Meta-Analysis

Discussion from the Agency for Health Care Policy and Research Inter-PORT Work Group on Literature Review/Meta-Analysis

Published in: Medical Care, v. 33, no. 2, Feb. 1995, p. 202-220

by Victor Hasselblad, Frederick Mosteller, Benjamin Littenberg, Thomas C. Chalmers, Maria Hunink, Judith A. Turner, Sally C. Morton, Paula Diehr, John B. Wong, Neil R. Powe

United States Agency for Health Care Policy and Research brought together representatives from each of the Patient Outcomes Research Teams (PORTs) as the Inter-Port Meta-Analysis Work Group. The purpose of the meeting was to discuss a wide range of problems the panel had encountered in the area of meta-analysis. Several actual problems were presented, and tentative solutions to those problems were given. The PORTs had to consider issues such as quality assessment, survival analysis, rare events, sensitivity and specificity, and random effects models. The solutions presented represent the methods used by several researchers who are active in the area of meta-analysis.

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