Clinical Focus What study reports were available on the use of SAMe for depression, ostheoarthritis, and liver disease? What types of outcomes were measured for the identified conditions? How did results for treatment with SAMe compare to placebo and conventional pharmacology? What non-English language publications on SAMe treatment are available and accessible? What is the methodological quality of the studies identified? Can results be pooled to allow a risk ratio and an effect size for SAMe to be calculated
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