Cover: Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)

Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)

Published in: Quality of Life Research, v. 15, no. 2, Mar. 2006, p. 299-305

Posted on 2006

by Kathleen Joy Propert, Mark Litwin, Y. Richard Wang, Richard B. Alexander, Elizabeth A. Calhoun, J. Curtis Nickel, Michael P. O'Leary, Michel A. Pontari, Mary McNaughton-Collins

OBJECTIVES: The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to assess symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The authors assessed the responsiveness of the NIH-CPSI to change over time and defined thresholds for changes perceptible to patients. METHODS: The authors studied 174 men with CP/CPPS who participated in a placebo-controlled randomized clinical trial. Changes from baseline to six weeks in the NIH-CPSI total score and pain, urinary, and quality of life subscores were compared to a global response assessment (GRA). Effect sizes and Guyatt statistics were calculated to evaluate responsiveness; 95% confidence intervals were produced using bootstrapping. RESULTS: All scores decreased over time with the largest decrease in subjects who reported on the GRA that they were markedly improved. The NIH-CPSI total, pain, and quality of life scores were highly responsive in the improved groups; the urinary score showed minimal responsiveness. There was no evidence of responsiveness among those subjects who worsened on the trial. ROC curves identified a 6-point decline in the NIH-CPSI total score as the optimal threshold to predict treatment response. CONCLUSIONS: The NIH-CPSI total score and pain and quality of life subscores are responsive to change over time.

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