A Morphologic and Immunologic Surface Marker Study of 299 Cases of Non-Hodgkin Lymphomas and Related Leukemias

Published in: American Journal of Pathology, v. 90, no. 2, Feb. 1978, p. 461-485

Posted on RAND.org on January 01, 1978

by R. J. Lukes, Clive R. Taylor, J. V. Parker, Thomas L. Lincoln, P. K. Pattengale, B. H. Tindle

Read More

Access further information on this document at ajp.amjpathol.org

This article was published outside of RAND. The full text of the article can be found at the link above.

This study relates the cytologic types of the classification of malignant lymphoma of Lukes and Collins to the results of immunologic surface marker studies as part of a systematic multiparameter study of 299 cases of non-Hodgkin lymphomas. The results support the hypothesis that malignant lymphomas are neoplasms of the immune system and involve the B- and T-cell systems and, rarely, histiocytes. The morphologic features of the cytologic types of Lukes and Collins are predictive of the subtypes of lymphoma and considerably more effective than the immunologic surface marker techniques in identifying homogeneous groups. There are considerable methodologic and interpretive problems that are evaluated in detail. The verification of the B- and T-cell subtypes of the Lukes and Collins classification indicates that the time has come to change from the terminology and classification of lymphomas of the past to a modern immunologic approach.

This report is part of the RAND Corporation External publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.