Describes the development of a 99-item epilepsy HRQOL inventory that includes the SF-36 as its core. Also included are 9 additional generic items, 48 epilepsy-targeted items, and 6 items concerning attitudes toward epilepsy and self-esteem. The inventory was administered to 304 adults at 25 epilepsy centers. Using a multitrait scaling analysis, 17 scales were developed that retained 86 items in those multi-item scales, and three single items. Validity analyses indicated that the epilepsy-targeted factors were more sensitive to categorization of patients by seizure frequency and type than scales tapping physical health, mental health, or cognitive function. The resulting Quality of Life in Epilepsy (QOLIE-89) inventory is more sensitive than a general measure of HRQOL and thus is more valuable for studying the impact of various procedures or drugs on the course of patients with epilepsy.
This report is part of the RAND Corporation External publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.
Our mission to help improve policy and decisionmaking through research and analysis is enabled through our core values of quality and objectivity and our unwavering commitment to the highest level of integrity and ethical behavior. To help ensure our research and analysis are rigorous, objective, and nonpartisan, we subject our research publications to a robust and exacting quality-assurance process; avoid both the appearance and reality of financial and other conflicts of interest through staff training, project screening, and a policy of mandatory disclosure; and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. For more information, visit www.rand.org/about/research-integrity.
The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.