Cover: Relationship of Isoniazid Resistance to Human Immunodeficiency Patients with Tuberculosis

Relationship of Isoniazid Resistance to Human Immunodeficiency Patients with Tuberculosis

Published in: American Journal of Respiratory and Critical Care Medicine, v. 153, no. 5, May 1996, p. 1708-1710

Posted on rand.org 1996

by Steven M. Asch, Laura Knowles, Anup Rai, Brenda E. Jones, Janice Pogoda, Peter Barnes

To investigate the relationship between isoniazid resistance and HIV infection in patients with tuberculosis, the authors evaluated data in the Los Angeles County tuberculosis registry on 1,506 patients for whom drug susceptibility results were available. Among 235 HIV-infected patients, isoniazid resistance was less common than in 1,271 patients who were HIV-seronegative or who had not been tested for HIV, with an unadjusted odds ratio of 0.3. After adjustment for other factors that affect drug resistance (ethnicity, country of birth, prior diagnosis of tuberculosis, and cavitation), the frequency of isoniazid resistance remained lower than that in patients without HIV infection, with an odds ratio of 0.4 (95% confidence interval, 0.2 to 0.8; p = 0.02). The authors conclude that in Los Angeles, a setting where there is no ongoing outbreak of drug-resistant tuberculosis, isoniazid-resistant tuberculosis is not more common in HIV-infected patients.

This report is part of the RAND external publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.

RAND is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.