Quebec Randomized Controlled Trial on Prostate Cancer Screening Shows No Evidence for Mortality Reduction

Published in: Prostate, Vol. 40, No. 2, Comment, 1999, p. 130-131

Posted on RAND.org on December 31, 1998

by Rob Boer, Fritz H. Schroder

Authors comment on a recent article on primary outcomes from the trial on prostate cancer screening in Quebec. The analysis as an observational study divided the trial population according to whether men in the study population actually had a screening or not. They comment that the data from the Quebec trial do not allow for an estimate of the magnitude of the possible self-selection bias. This method of analysis should therefore not have been used, not even if the original design of this research had been an observational study instead of a randomized trial.

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