Knowledge of Antiretroviral Regimen Dosing and Adherence

A Longitudinal Study

Published in: Clinical Infectious Diseases, v. 36, no. 4, Feb. 15, 2003, p. 514-518

by Loren G. Miller, Honghu H. Liu, Ron D. Hays, Carol E. Golin, Zhishen Ye, C. Keith Beck, Andrew H. Kaplan, Neil S. Wenger

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In a cohort of 128 human immunodeficiency virus-infected patients, the authors found that patients' knowledge of antiretroviral dosing was suboptimal at regimen initiation but improved with time. Poor medication knowledge 8 weeks after regimen initiation was associated with lower adherence and with a lower level of literacy in a multivariate model (P=.03). Because knowledge deficits are common after antiretroviral regimen initiation, clinicians should assess patients' understanding of medication dosing soon after regimen initiation or change.

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