Knowledge of Antiretroviral Regimen Dosing and Adherence

A Longitudinal Study

Published in: Clinical Infectious Diseases, v. 36, no. 4, Feb. 15, 2003, p. 514-518

Posted on RAND.org on January 01, 2003

by Loren G. Miller, Honghu H. Liu, Ron D. Hays, Carol E. Golin, Zhishen Ye, C. Keith Beck, Andrew H. Kaplan, Neil S. Wenger

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In a cohort of 128 human immunodeficiency virus-infected patients, the authors found that patients' knowledge of antiretroviral dosing was suboptimal at regimen initiation but improved with time. Poor medication knowledge 8 weeks after regimen initiation was associated with lower adherence and with a lower level of literacy in a multivariate model (P=.03). Because knowledge deficits are common after antiretroviral regimen initiation, clinicians should assess patients' understanding of medication dosing soon after regimen initiation or change.

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