Interstitial Cystitis and Painful Bladder Syndrome

Published In: Urologic Diseases In America / Edited By Mark S. Litwin and Christopher S. Saigal (Washington, D.C.: US Department of Health and Human Services, Public Health, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2007), Chapter 4, p. 125-154, NIH Pub. no. 07-5512

Posted on on January 01, 2007

by J. Quentin Clemens, Geoffrey F. Joyce, Matthew Wise, Christopher K. Payne

Read More

Access further information on this document at

This article was published outside of RAND. The full text of the article can be found at the link above.

Interstitial cystitis (IC) and painful bladder syndrome (PBS) are enigmatic chronic conditions characterized by frequent urination and bladder pain. Onset frequently occurs in the patient's fourth decade or after, and the disease typically fluctuates in severity but rarely resolves completely. Patients suffer considerable morbidity over the course of their lives, especially during the most productive years for work and family life, especially during the most productive years for work and family life. Although the data presented in this chapter focus on the direct medical costs of IC, patients are equally, if not more, affected by loss of work opportunities, effects on relationships, and overall diminished quality of life. Progress in addressing this disease has been painstakingly slow due to a lack of understanding of the underlying pathophysiology, significant disagreements about its diagnosis, lack of a marker for the disease or its activity, and lack of effective treatments. The National Institutes of Health has funded a number of initiatives in both the clinical and basic science of IC over the past 15 years.

This report is part of the RAND Corporation External publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.

Our mission to help improve policy and decisionmaking through research and analysis is enabled through our core values of quality and objectivity and our unwavering commitment to the highest level of integrity and ethical behavior. To help ensure our research and analysis are rigorous, objective, and nonpartisan, we subject our research publications to a robust and exacting quality-assurance process; avoid both the appearance and reality of financial and other conflicts of interest through staff training, project screening, and a policy of mandatory disclosure; and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. For more information, visit

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.