Effect of Complications on Mortality After Coronary Artery Bypass Grafting Surgery

Evidence from New York State

Published in: The Journal of Thoracic and Cardiovascular Surgery, v. 134, no. 1, July 2007, p. 53-58

Posted on RAND.org on January 01, 2007

by Laurent G. Glance, Turner M. Osler, Dana B. Mukamel, Andrew W. Dick

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OBJECTIVE: Complications are associated with increased risk of death. The objective of this study is to quantify the increased odds of dying from complications after isolated coronary artery bypass grafting surgery. METHODS: The authors conducted a retrospective cohort study using the New York State Coronary Artery Bypass Grafting Surgery Reporting System for all patients undergoing isolated coronary artery bypass grafting surgery in New York State who were discharged between 1997 and 1999 (51,750 patients; 2.20% mortality). The authors estimated the independent effect of individual postoperative complications on in-hospital mortality after controlling for patient clinical risk factors and demographics. RESULTS: The mortality rate for patients without complication was 0.77% versus 16.1% for patients with complications (P < .001). After adjusting for preoperative risk factors, transmural myocardial infarction (adjusted odds ratio, 7.90; P < .001), respiratory failure (adjusted odds ratio, 6.02; P < .001), renal failure (adjusted odds ratio, 7.15; P < .001), and stroke within 24 hours (adjusted odds ratio, 4.09; P < .001) were the most strongly associated with mortality. CONCLUSIONS: There is a strong association between postoperative complications and in-hospital mortality. Complications after isolated coronary artery bypass grafting surgery are associated with a 1.4- to 8-fold increase in the odds of death after adjusting for severity of disease and comorbidities. This information might prove valuable to hospitals in their efforts to design quality improvement initiatives and care protocols to improve mortality after coronary artery bypass grafting surgery.

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