Concordance of Chlamydia Trachomatis Infections Within Sexual Partnerships

Published in: Sexually transmitted infections, v. 84, no. 1, Feb. 2008, p. 23-28

Posted on RAND.org on January 01, 2008

by S. M. Rogers, W. C. Miller, Charles F. Turner, Jonathan Ellen, J Zenilman, Richard Rothman, M. A. Villarroel, A. Al-Tayyib, P Leone, Charlotte Gaydos, L Ganapathi, Walter V. Hobbs, David E. Kanouse

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OBJECTIVES: The enhanced sensitivity of nucleic acid amplification tests (NAAT) provides an opportunity for estimating the prevalence of untreated Chlamydia trachomatis infections. The transmissibility and public health significance of some NAAT-identified infections are, however, not known. METHODS: Adults attending an urban emergency department provided specimens for C trachomatis screening using NAAT. Participants testing positive were offered follow-up including re-testing for C trachomatis using NAAT and traditional methods, eg culture and direct fluorescent antibody, and were treated. Partners were offered identical evaluation and treatment. Overall, 90 C trachomatis-positive participants had one or more sexual partners enrolled. RESULTS: Evidence of transmission, as defined by infection concordance between partnerships, was observed among 75% of partners of index cases testing positive by both NAAT and traditional assay but only 45% of partners of index cases testing positive by NAAT only (prevalence ratio 1.7, 95% CI 1.1 to 2.5). Among index participants returning for follow-up, 17% had no evidence of C trachomatis infection by NAAT or traditional assay (median follow-up three weeks). CONCLUSIONS: A substantial proportion of positive NAAT results for chlamydial infection may be of lower transmissibility and may not persist after a short follow-up. The long-term health effects of some positive NAAT are uncertain.

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