This report jointly produced by RAND Europe and the Leadership Foundation for Higher Education examines and analyses collaborative activity between UK higher education institutions (HEIs) and organisations external to the higher education sector. HEIs have been developing collaborative relationships for many generations, and the scale and range of these activities have increased significantly in recent years. The findings from this report are based on a literature review, seven selected UK case studies and one European case study. Report findings present some clear pointers to the effective leadership of collaborations. Findings provide insight on the purpose of leadership, and how leadership can be exerted and distributed throughout a collaboration; the skills, roles and communication required for effective relationships; governance structures; and the importance of conflict management and conflict resolution. It concludes with recommendations for HEIs when embarking upon collaborative activity.