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This report, which provides a knowledge base for the development of methadone maintenance treatment clinical guidelines in Switzerland, reviews the world-wide literature (except for Switzerland, which is the subject of a separate investigation) on such treatment and existing guidelines. Articles on methadone maintenance treatment and concurring treatment modalities are discussed in detail, as well as existing knowledge about specific populations, such as pregnant addicts and addicts with HIV or tuberculosis. Research on prognostic factors to patients' responses to treatment and perceptions of opiate dependent persons are also reviewed to ascertain their value to practitioners in managing methadone maintenance treatment and in assessing the best possible treatment. A final chapter describes other substitution treatments in comparison to methadone maintenance and synthesizes the information of the review into a structured information source for thinking about guideline development.
Table of Contents
Chapter One
Introduction
Chapter Two
Study Design
Chapter Three
Guidelines and Clinical Practice Recommendations
Chapter Four
Methadone - Characteristics of the Drug
Chapter Five
Treatment Outcome Studies
Chapter Six
Special Populations
Chapter Seven
Studies Describing Psychosocial and Other Non-Pharmacological Aspects of Treatment
Chapter Eight
Perceptions of Addicts of Methadone Maintenance Treatment
Chapter Nine
Methadone Maintenance Treatment As Compared to Other Substitution Treatments
Chapter Ten
Conclusions: Recommendations for Guideline Development
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The research described in this report was performed within RAND Europe and RAND's Drug Policy Research Center.
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