The distribution of a drug in the body.
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A continuation of P-1550, Some Mathematical Aspects of Chemotherapy-I: One-organ Models, which considers a model of the distribution of a compound within the plasma flowing through a capillary bed and within the extracellular space and intracellular space. The model includes the possibility of the reaction of the drug with a component of the intracellular space. The present paper extends the model to include the effects of the major tissues of the body and circulation. An attempt is made to show the relationship of this general problem to feedback problems, input-output analysis, and transportation problems arising in economic and engineering control processes. An extension of the model discussed in P-1550, to include the effects of the major tissues of the body and circulation. An attempt is made to show the relationship of this general problem to feedback problems, input-output analysis, and transportation problems arising in economic and engineering control processes. 22 pp.
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