The distribution of a drug in the body.

John A. Jacquez, Richard Ernest Bellman, Robert E. Kalaba

ResearchPublished 1958

A continuation of P-1550, Some Mathematical Aspects of Chemotherapy-I: One-organ Models, which considers a model of the distribution of a compound within the plasma flowing through a capillary bed and within the extracellular space and intracellular space. The model includes the possibility of the reaction of the drug with a component of the intracellular space. The present paper extends the model to include the effects of the major tissues of the body and circulation. An attempt is made to show the relationship of this general problem to feedback problems, input-output analysis, and transportation problems arising in economic and engineering control processes. An extension of the model discussed in P-1550, to include the effects of the major tissues of the body and circulation. An attempt is made to show the relationship of this general problem to feedback problems, input-output analysis, and transportation problems arising in economic and engineering control processes. 22 pp.

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  • Copyright: RAND Corporation
  • Availability: Available
  • Year: 1958
  • Print Format: Paperback
  • Paperback Pages: 22
  • Paperback Price: $15.00
  • Document Number: P-1560-RC

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RAND Style Manual
Jacquez, John A., Richard Ernest Bellman, and Robert E. Kalaba, The distribution of a drug in the body. RAND Corporation, P-1560-RC, 1958. As of September 14, 2024: https://www.rand.org/pubs/papers/P1560.html
Chicago Manual of Style
Jacquez, John A., Richard Ernest Bellman, and Robert E. Kalaba, The distribution of a drug in the body. Santa Monica, CA: RAND Corporation, 1958. https://www.rand.org/pubs/papers/P1560.html. Also available in print form.
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