Therapeutic Implications of Physicochemical Phenomena Involved in Sickle-Cell Disease

by James C. DeHaven


Download eBook for Free

FormatFile SizeNotes
PDF file 1.2 MB

Use Adobe Acrobat Reader version 10 or higher for the best experience.


Purchase Print Copy

 FormatList Price Price
Add to Cart Paperback32 pages $20.00 $16.00 20% Web Discount

Discusses the sickling of red blood cells from a biophysical-chemical view, and develops a rationale for a screening methodology to be used in selecting therapeutic agents for alleviating the symptoms of sickle-cell crises. Low solubility of deoxygenated hemoglobin S (HbS) is accepted as the ultimate cause of the signs and symptoms of sickle-cell disease and associated crises. The study surveys methods that may increase solubility of HbS. They involve, in one manner or another, the physicochemical solution properties of the blood fluids, and include: salting-in of HbS; altering the relative activity coefficients for water in plasma and erythrocytes; and increasing presickling cell volumes through osmosis, inhibited cell metabolism, and controlled hemolysis. The study lists and discusses possible therapeutic agents that each of these modes suggests as possible candidates for evaluation.

This report is part of the RAND Corporation Report series. The report was a product of the RAND Corporation from 1948 to 1993 that represented the principal publication documenting and transmitting RAND's major research findings and final research.

This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited; linking directly to this product page is encouraged. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial purposes. For information on reprint and reuse permissions, please visit

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.