A first-order characterization of clinical trials

by Marsha Hopwood, John C. Mabry, W. L. Sibley


Purchase Print Copy

 FormatList Price Price
Add to Cart Paperback102 pages $30.00 $24.00 20% Web Discount

Presents the results of the first year of a two-year project to evaluate the role of NIH-supported General Clinical Research Centers in clinical trials. To provide a context for the evaluation, the authors conducted a literature review and interviews with about 100 people, and developed a broad characterization of clinical trials, their problems, and tentative solutions. A key distinction between clinical trials and other clinical research is the extensive information processing that the trials require. Thus, special emphasis was placed on information processing problems, which include the administrative, organizational, and operational problems relating to the communication and manipulation of information. Future clinical trials would benefit from increased attention to planning (particularly the nonmedical aspects), the availability of trained support staff and appropriate information processing resources, improved technical communication among professional and support staffs, better personnel management, and a framework for communicating trial methodology and findings to researchers, health care practitioners, and the public.

This report is part of the RAND Corporation Report series. The report was a product of the RAND Corporation from 1948 to 1993 that represented the principal publication documenting and transmitting RAND's major research findings and final research.

Our mission to help improve policy and decisionmaking through research and analysis is enabled through our core values of quality and objectivity and our unwavering commitment to the highest level of integrity and ethical behavior. To help ensure our research and analysis are rigorous, objective, and nonpartisan, we subject our research publications to a robust and exacting quality-assurance process; avoid both the appearance and reality of financial and other conflicts of interest through staff training, project screening, and a policy of mandatory disclosure; and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. For more information, visit www.rand.org/about/research-integrity.

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.