Approximations to a Conservative Inverse Chi-Square Procedure for Combining P-Values in Integrative Research

by Hilary Saner


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The use of p-values in combining the results of independent studies often involves studies that are potentially aberrant. This suggests the use of a statistic which trims some of the smallest and largest p-values. The authors provide two convenient approximations to the exact distribution of the trimmed Fisher statistic. The first utilizes Pearson's system of curve classification, while the second is a normal approximation.

Originally published in: Statistics & Probability Letters, v. 15, 1992, pp. 215-222.

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