A Mathematical Model for Post-Irradiation Hematopoietic Recovery.

James P. OKunewick, A. L. Kretchmar

ResearchPublished 1967

A mathematical model of the recovery after irradiation of the system producing blood cells in the body. The model is based on the hypothesis that hematopoietic stem cells, which are unable to reproduce as stem cells following irradiation, may still retain an ability to differentiate. The model demonstrates both an abortive recovery rise and a true recovery rise following irradiation. As a first approximation, the model shows no irreconcilable differences from experimental data and generally represents the phenomena observed in the recovery of erythropoiesis following acute irradiation. In addition, certain postulates basic to blood-cell development are derived. 42 pp. Ref.

Document Details

  • Copyright: RAND Corporation
  • Availability: Web Only
  • Year: 1967
  • Pages: 42
  • Document Number: RM-5272-PR

Citation

Chicago Manual of Style

OKunewick, James P. and A. L. Kretchmar, A Mathematical Model for Post-Irradiation Hematopoietic Recovery. Santa Monica, CA: RAND Corporation, 1967. https://www.rand.org/pubs/research_memoranda/RM5272.html.
BibTeX RIS

This publication is part of the RAND research memorandum series. The research memorandum series, a product of RAND from 1948 to 1973, included working papers meant to report current results of RAND research to appropriate audiences.

This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited; linking directly to this product page is encouraged. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial purposes. For information on reprint and reuse permissions, please visit www.rand.org/pubs/permissions.

RAND is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.