A Mathematical Model for Post-Irradiation Hematopoietic Recovery.

by James P. OKunewick, A. L. Kretchmar

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A mathematical model of the recovery after irradiation of the system producing blood cells in the body. The model is based on the hypothesis that hematopoietic stem cells, which are unable to reproduce as stem cells following irradiation, may still retain an ability to differentiate. The model demonstrates both an abortive recovery rise and a true recovery rise following irradiation. As a first approximation, the model shows no irreconcilable differences from experimental data and generally represents the phenomena observed in the recovery of erythropoiesis following acute irradiation. In addition, certain postulates basic to blood-cell development are derived. 42 pp. Ref.

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