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The purpose of this document is to provide an overview of Project Retrosight, a study of the translation of basic and early clinical biomedical research into clinical practice in four countries over a 10-20 year period. The document also provides a description of the research process for the study, with illustrative examples and resources such as protocols to assist researchers and provide guidance through the research and reporting process. The intended audiences are the participating funders and the in-country study teams who will be conducting case studies for Retrosight. The discussion provides insights into how issues were resolved or decisions made in developing the framework or conducting certain cases. In doing so, the research pack does not attempt to provide comprehensive prescriptions or instructions for participating research teams. It is intended to generate further discussion to be pursued at the workshop on 27-28 February 2007.

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The research in this report was prepared for the Project Retrosight participating research teams conducted by RAND Europe.

This report is part of the RAND working paper series. RAND working papers are intended to share researchers' latest findings and to solicit informal peer review. They have been approved for circulation by RAND but may not have been formally edited or peer reviewed.

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