This paper examines the validity of the CRC-SPIN model and colonoscopy sensitivity assumptions. We find that colonoscopy may be less accurate than currently assumed, especially for diminutive adenomas.
Aug 17, 2022
Carolyn Rutter (she/her) is a senior statistician at the RAND Corporation and a professor at Pardee RAND Graduate School. Her research interests include microsimulation modeling, developing and applying Bayesian models, evaluation of diagnostic and screening tests, and meta-analysis and systematic reviews. Rutter is a principal investigator (PI) for a Cancer Intervention and Surveillance Modeling Network (CISNET) team and led the development of the CRC-SPIN microsimulation model for colorectal cancer. She developed a likelihood-free method for model calibration, implemented using the R package "imabc". This method is especially useful for complex models that are calibrated to multiple targets. She also has an interest in understanding and addressing health care inequities and disparities, and assessing health care quality and provider performance. Rutter is a fellow of the American Statistical Association with more than 150 articles published in peer-reviewed journals, including Annals of Internal Medicine, Annals of Applied Statistics, Biostatistics, Journal of the American Statistical Society, Journal of the National Cancer Institute, Medical Decision Making, Medical Care, and Statistics in Medicine. Rutter is an associate editor for Statistics in Medicine and serves on the editorial board for Medical Decision Making and Statistics in Medicine. Rutter received her Ph.D. in biostatistics from UCLA and completed post-doctoral training in Department of Health Care Policy at Harvard Medical School.
Rutter CM, Ozik J, DeYoreo, Collier N, "Microsimulation Model Calibration using Incremental Mixture Approximate Bayesian Computation," Annals of Applied Statistics, 13(4), 2019
Knudsen AB, Rutter CM, Peterse EFP, Lietz AP; Seguin CL; Meester RGS; Perdue LA; Lin JS; Siegel RL; Doria-Rose VP; Feuer EJ; Zauber AG; Kuntz KM; Lansdorp-Vogelaar I., "Colorectal Cancer Screening: An Updated Modeling Study for the US Preventive Services Task Force," JAMA, 325(19), 2021
Rutter CM, Nascimento de Lima P, Lee JK, Ozik J, "Too Good to Be True? Evaluation of Colonoscopy Sensitivity Assumptions Used in Policy Models,," Cancer Epidemiology Biomarkers and Prevention. DOI: 10.1158/1055-9965.EPI-21-1001 (forthcoming)
Rutter CM, May FP, Coronado GD, Pujol TA, Thoma EG, Cabreros I, "Racism is a modifiable Risk Factor: Relationships between Race, Ethnicity, and Colorectal Cancer Outcomes," Gastroenterology, DOI: 0.1053/j.gastro.2021.12.251
Rutter CM, Knudsen AB, Lin JS, Bouskill KE., "Black and White Differences in Colorectal Cancer Screening and Screening Outcomes: A Narrative Review," Cancer Epidemiology Biomarkers and Prevention, 30(1), 2021
Rutter CM, Inadomi JM, Maerzluft CE, "The impact of cumulative colorectal cancer screening delays: A simulation study," Journal of Medical Screening. DOI: 10.1177/09691413211045103
Rutter CM, Kim JJ, Meester RGS, Sprague BL, Burger EA, Zauber AG, Ergun MA, Campos NG, Doubeni CA, Trentham-Dietz A, Sy S, Alagoz O, Stout NK, Lansdorp-Vogelaar I, Corley DA, Tosteson ANA. , "Effect of Time to Diagnostic Testing for Breast, Cervical, and Colorectal Cancer Screening Abnormalities on Screening Efficacy: A Modeling Study," Cancer Epidemiology Biomarkers and Prevention, 2018