RE: Surveys Identify Barriers to Participation in Clinical Trials

Published In: Journal of the National Cancer Institute, Vol. 93, no. 3, 2001, Correspondence, p. 238-239

by Nikhil Wagle, Dana P. Goldman, Meredith L. Kilgore

Read More

Access further information on this document at

This article was published outside of RAND. The full text of the article can be found at the link above.

One of the most pressing issues in clinical cancer research is the relatively small number of patients enrolled in clinical trials. In a recent two-part News series, Finn wrote, fewer than 3% of adults with cancer participate in clinical trials. This figure is the most commonly used statistic in discussing cancer trial participation. It has been cited numerous times in both medical and health services journals and by advocacy organizations, and, most prominently, President Clinton used it in his Executive Memorandum directing Medicare to cover routine costs of care in clinical trials. Unfortunately, this figure misrepresents the number of cancer patients treated in experimental therapeutic trials.

This report is part of the RAND Corporation External publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.

Our mission to help improve policy and decisionmaking through research and analysis is enabled through our core values of quality and objectivity and our unwavering commitment to the highest level of integrity and ethical behavior. To help ensure our research and analysis are rigorous, objective, and nonpartisan, we subject our research publications to a robust and exacting quality-assurance process; avoid both the appearance and reality of financial and other conflicts of interest through staff training, project screening, and a policy of mandatory disclosure; and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. For more information, visit

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.