Effect of Supplemental Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cardiovascular Disease

Published in: Evidence Report/Technology Assessment: no. 83 (Prepared by the Southern California/RAND Evidence-based Practice Center under contract No. 290-97-0001). AHRQ Publication No. 03-E043. Agency for Healthcare Research and Quality, Rockville, MD. July 2003

Posted on RAND.org on January 01, 2003

by Paul G. Shekelle, Sally C. Morton, Mary L. Hardy

Read More

Access further information on this document at archive.ahrq.gov

This article was published outside of RAND. The full text of the article can be found at the link above.

The purpose of this study was to conduct a systematic review of the scientific literature to identify and assess the evidence for the efficacy of the antioxidant supplements vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cardiovascular disease or modification of known risk factors for cardiovascular disease. It was our intention to perform meta-analyses where possible. The results may be used to develop a research agenda as well as to assist clinicians in advising patients who desire to take antioxidants to modify their risk of cardiovascular disease.

This report is part of the RAND Corporation External publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.

Our mission to help improve policy and decisionmaking through research and analysis is enabled through our core values of quality and objectivity and our unwavering commitment to the highest level of integrity and ethical behavior. To help ensure our research and analysis are rigorous, objective, and nonpartisan, we subject our research publications to a robust and exacting quality-assurance process; avoid both the appearance and reality of financial and other conflicts of interest through staff training, project screening, and a policy of mandatory disclosure; and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. For more information, visit www.rand.org/about/principles.

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.