An Evidence Map of Treatments for Infantile Epilepsy

Published in: Epilepsy Research, Volume 178 (December 2021). doi: 10.1016/j.eplepsyres.2021.106781

Posted on RAND.org on October 24, 2022

by Eric Apaydin, Arthur Partikian, Julia Rollison, Sangita M. Baxi, Ning Fu, Susanne Hempel

Epilepsy prevalence is high among infants, but treatment guidelines are not clear. We conducted a scoping review of interventions to manage epilepsy in infants, and identified 37 studies. Most studies reported that interventions were effective (22 studies; 76%), but randomized controlled trials were uncommon (7 studies; 19%) and sample sizes were small (range: 2 to 284 participants; mean: 69.4; 95% confidence interval: 49.5, 89.2). Additional high quality research and systematic reviews on interventions for infantile epilepsy are needed to establish better treatment guidelines for the disease.

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