Cover: Commentary

Commentary

Liquid Biopsy for Average-Risk Colorectal Cancer Screening

Published in: Clinical Gastroenterology and Hepatology (2024). DOI: 10.1016/j.cgh.2024.01.034

Posted on rand.org Mar 28, 2024

by David A. Lieberman, Aasma Shaukat, Folasade P. May, John M. Carethers, Iris Lansdorp-Vogelaar, Uri Ladabaum, Timothy R. Church, Anjelica Davis, Chyke A. Doubeni, John M. Inadomi, et al.

Despite well-known benefits and clear evidence of programmatic effectiveness in the average-risk population, colorectal cancer (CRC) screening in the United States remains underutilized. Only 60% to 65% of age-eligible individuals are up to date with screening. Emerging blood tests (liquid biopsies [LBs]) detecting circulating nucleotides such as cell-free DNA and/or metabolic products associated with CRC and its precursors could help expand screening. Introduction of new noninvasive screening tests could mitigate disparities, although the high cost could widen disparities.

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