Initiating Clinical Trials

A Case Study of Extracranial-Intracranial Anastomosis

Geoffrey M. Anderson, James P. Kahan

ResearchPublished 1985

This Note describes the major determinants of the decisions to initiate and to fund a randomized clinical trial of extracranial/intracranial (EC/IC) bypass for stroke prevention. It describes (1) the sources of data; (2) what was known about stroke prevention in 1977; (3) the decision to initiate the EC/IC bypass trial, using a model that suggests relevance and feasibility are important factors in the decision to develop a clinical trial; (4) the peer review of the scientific merit of the grant application and the National Institute of Neurological and Communicative Disorders and Stroke Advisory Council's decision to recommend funding the trial; and (5) conclusions regarding the decisions to initiate and fund clinical trials.

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Document Details

  • Copyright: RAND Corporation
  • Availability: Available
  • Year: 1985
  • Print Format: Paperback
  • Paperback Pages: 31
  • Paperback Price: $20.00
  • Document Number: N-2320/1-NCHSR

Citation

RAND Style Manual
Anderson, Geoffrey M. and James P. Kahan, Initiating Clinical Trials: A Case Study of Extracranial-Intracranial Anastomosis, RAND Corporation, N-2320/1-NCHSR, 1985. As of September 14, 2024: https://www.rand.org/pubs/notes/N2320z1.html
Chicago Manual of Style
Anderson, Geoffrey M. and James P. Kahan, Initiating Clinical Trials: A Case Study of Extracranial-Intracranial Anastomosis. Santa Monica, CA: RAND Corporation, 1985. https://www.rand.org/pubs/notes/N2320z1.html. Also available in print form.
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