Cover: Initiating Clinical Trials

Initiating Clinical Trials

A Case Study of Intermittent Positive Pressure Breathing

by Elizabeth A. McGlynn, James P. Kahan

Purchase

Purchase Print Copy

 FormatList Price Price
Add to Cart Paperback38 pages $20.00 $16.00 20% Web Discount

This Note describes the events surrounding the decision by the National Heart and Lung Institute (NHLI) to issue a request for proposal (RFP) to conduct a multicenter randomized clinical trial comparing the efficacy of intermittent positive pressure breathing (IPPB) with compressor nebulizer therapy in treating patients with chronic obstructive pulmonary disease (COPD). The Note describes (1) the disease process associated with COPD and the history of IPPB treatment for this disease; (2) the decisionmaking process that led to NHLI's decision to issue an RFP for the study of IPPB therapy; (3) the motivations of three of the investigators responding to the RFP; and (4) the case study as a model for future decisionmaking.

This report is part of the RAND Corporation Note series. The note was a product of the RAND Corporation from 1979 to 1993 that reported other outputs of sponsored research for general distribution.

This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited; linking directly to this product page is encouraged. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial purposes. For information on reprint and reuse permissions, please visit www.rand.org/pubs/permissions.

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.