Research
The Decision to Initiate Clinical Trials of Current Medical Practices
Jan 1, 1985
Initiating Clinical Trials
A Case Study of Intermittent Positive Pressure Breathing
Published 1985
This Note describes the events surrounding the decision by the National Heart and Lung Institute (NHLI) to issue a request for proposal (RFP) to conduct a multicenter randomized clinical trial comparing the efficacy of intermittent positive pressure breathing (IPPB) with compressor nebulizer therapy in treating patients with chronic obstructive pulmonary disease (COPD). The Note describes (1) the disease process associated with COPD and the history of IPPB treatment for this disease; (2) the decisionmaking process that led to NHLI's decision to issue an RFP for the study of IPPB therapy; (3) the motivations of three of the investigators responding to the RFP; and (4) the case study as a model for future decisionmaking.
Topics
Document Details
- Copyright: RAND Corporation
- Availability: Web Only
- Year: 1985
- Pages: 38
- DOI: https://doi.org/10.7249/pubs
- Document Number: N-2320/4-NCHSR
Citation
RAND Style Manual
McGlynn, Elizabeth A. and James P. Kahan, Initiating Clinical Trials: A Case Study of Intermittent Positive Pressure Breathing, RAND Corporation, N-2320/4-NCHSR, 1985. As of July 14, 2026: https://www.rand.org/pubs/notes/N2320z4.html
Chicago Manual of Style
McGlynn, Elizabeth A. and James P. Kahan, Initiating Clinical Trials: A Case Study of Intermittent Positive Pressure Breathing. Santa Monica, CA: RAND Corporation, 1985. https://www.rand.org/pubs/notes/N2320z4.html.
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