Cell Kinetics Simulation in the Treatment of Acute Granulocytic Leukemia.

Thomas L. Lincoln

Expert InsightsPublished 1972

Describes systems of models simulating patient response to cancer chemotherapy and various mechanisms of blood and blood forming tissues. Such models will make it possible to choose a drug-dosage strategy favoring destruction of tumor cells and minimizing the effect on healthy cell systems. The simulations use the BIOMOD system, developed at RAND, with online interactive graphic capability including data tablet and 1024 x 1024 screen. The ability to explore the implications of a simulation during its course makes the system a powerful tool. The inputs to the leukemia program include patient history and a hypothetical future schedule of drug dosage. The outputs are the daily predicted future values of circulating bloodcell and platelet concentrations as affected only by the leukemia, ignoring changes due to complications. Thus, as new drugs and insight develop, hypotheses may be tested without undue risk to the patient. 10 pp. Ref.

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Lincoln, Thomas L., Cell Kinetics Simulation in the Treatment of Acute Granulocytic Leukemia. Santa Monica, CA: RAND Corporation, 1972. https://www.rand.org/pubs/papers/P4774.html.
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