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Cancer Treatment

Journal Article
Cost-Effectiveness Analysis of CAR T-Cell Therapies Vs Antibody Drug Conjugates for Patients with Advanced Multiple Myeloma
In this analysis, we built a Monte Carlo Markov Chain microsimulation model using estimates and parameters from the evidence on standard treatment for multiple myeloma and chimeric antigen receptor T-cell therapies.
Jan 25, 2023
Journal Article
Consensus-Based Guidance on Opioid Management in Individuals With Advanced Cancer-Related Pain and Opioid Misuse or Use Disorder
This qualitative study provides consensus-based guidance for clinicians and highlights research and policy gaps that warrant urgent attention to meet the needs of people with cancer-related pain and opioid misuse/use disorder.
Sep 21, 2022
Journal Article
Enhancing Access to and Diversity in Cancer Clinical Trials Through a Financial Reimbursement Program: Protocol to Evaluate a Novel Program
We implemented a financial reimbursement and outreach program designed to increase the number and diversity of participants in cancer clinical trials at centers in Dallas, Houston, and Philadelphia.
Sep 15, 2022
Journal Article
Barriers to Chimeric Antigen Receptor T-Cell (CAR-T) Therapies in Clinical Practice
The barriers to the use of CAR-T therapy include complex logistics, manufacturing limitations, toxicity concerns, and financial burden. This review discusses solutions to overcome these barriers to make this therapy widely accessible.
Sep 15, 2022
Journal Article
Narrative Review and Evidence Mapping: Proteomics for Cancer and Cardiovascular Disease
This report presents evidence supporting proteomic tests for cancer and cardiovascular disease currently approved in the United States and proteomic tests that may be available in the near term.
Aug 26, 2021
Journal Article
B-cell Lymphoma and Non-Hodgkin's Lymphoma Treatment: How Do Participants of Chimeric Antigen Receptor T-cell (CAR-T) Therapy Research Studies Compare With Patients in the US Population?
Chimeric antigen receptor (CAR)-T-cell therapy appears to be a promising treatment for B-cell and non-Hodgkin's lymphoma. CAR-T therapy effectiveness in the general population of patients may differ from effectiveness demonstrated in trials.
Jun 17, 2021
Journal Article
Evidence Map of Ductal Carcinoma in Situ Management Options
This is an evidence-map of ductal carcinoma in situ treatment options and impacts on patient-centered and clinical options.
May 26, 2021
Commentary
More Could Be Spent on Recruiting and Training Cancer Staff if the NHS Is to Provide a World-Class Cancer Service
Cancer is a leading cause of death in the UK. Action is needed now to recruit and train more NHS staff in certain key cancer-related roles if NHS is to meet its ambitions for improving cancer services over the next 10 years.
Dec 10, 2020
Journal Article
Estimating the Cost of Growing the NHS Cancer Workforce in England by 2029
This research aims to understand the requirements for the NHS, and particularly for HEE, of increasing the seven priority cancer workforces by 45 per cent by 2029.
Oct 14, 2020
Journal Article
The Complex Cancer Care Coverage Environment: What Is the Role of Legislation? A Case Study from Massachusetts
We identified five current cancer coverage state laws and interviewed experts on their perceptions of the relevance of the laws and how well they meet the current needs of cancer care given rapid changes in therapies.
Oct 13, 2020
Journal Article
Health System and Beneficiary Costs Associated With Intensive End-of-Life Medical Services
The objective of this paper is to quantify expected beneficiary and health system costs incurred in association with receipt of intensive medical services in the last month of life.
Mar 11, 2020
Commentary
Treating Breast Cancer Is Not Just About the Disease: Its Wider Impacts Need to Be Considered, Too
Successes in the early treatment of breast cancer are to be celebrated. But those achievements need not limit the development of further and better treatment for patients. Understanding the disease's wider effects could help bring this about.
Oct 22, 2019
Report
Factors affecting access to treatment of early breast cancer: Case studies from Brazil, Canada, Italy, Spain and UK: Implications for future research, policy and practice
RAND Europe conducted a study on the societal impact of early breast cancer, divided into three interconnected phases. The third phase was a qualitative study assessing the factors affecting access and delivery of treatment for early breast cancer.
Jun 11, 2019
Report
A Review of the Research Landscape for Treatment of Early Breast Cancer: Implications for future research, policy and practice
RAND Europe conducted a study on the societal impact of early breast cancer. This study was divided into three interconnected phases. The first phase was a mapping review on the published literature on the impacts of treatment of early breast cancer.
Jun 11, 2019
Report
Findings from a systematic review to explore the patient and societal impacts of disease progression in women who were treated for early breast cancer: Implications for future research, policy and practice
RAND Europe conducted a study on the societal impact of early breast cancer. This study was divided into three connected phases. The second phase was a systematic review on non-clinical outcomes of recurrence after treatment of early breast cancer.
Jun 11, 2019
Report
Understanding the societal impact of treatment of early breast cancer: What are the non-clinical outcomes associated with disease progression?
RAND Europe conducted a study on the societal impact of early breast cancer. This study was divided into three interconnected phases. This is the summary report of the cross-analysis of data gathered through the three phases.
Jun 11, 2019
Journal Article
Describing Care Coordination of Gynecologic Oncology in Western Healthcare Settings: A Rapid Review
This article discusses a rapid review of the literature on characteristics of care coordination for gynecologic malignancies.
Jul 6, 2018
Journal Article
Variations in Oncologist Recommendations for Chemotherapy for Stage IV Lung Cancer: What Is the Role of Performance Status?
Oncologists often recommend chemotherapy to stage-IV non-small-cell lung cancer patients who are unlikely to benefit from this treatment.
Nov 4, 2016
Journal Article
Association Between Number of Endoscopic Resections and Utilization of Bacillus Calmette-Guérin Therapy for Patients with High-Grade, Non-Muscle-Invasive Bladder Cancer
Using induction Bacillus Calmette-Guérin (the reference standard treatment) early when treating non–muscle-invasive bladder cancer could help prevent reoccurrences rather than just reacting to them.
Aug 26, 2016
Journal Article
The Impact of Cancer and Quality of Life Among Long-Term Survivors of Breast Cancer in Austria
Perceptions of breast cancer's effect among long term survivors in Austria are influenced by, and in term potentially influence, the survivors' physical and mental health-related quality of life.
Jul 14, 2016

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Research conducted by

RAND Health Care