The Clinical Significance of Simulation and Modeling in Leukemia Chemotherapy.

Thomas L. Lincoln

Expert InsightsPublished 1972

Describes the use of mathematical modeling and computer simulation in the management of leukemia through chemotherapy. Treatment of leukemia is quantitative and offers a spectrum of options. The objective of chemotherapy is to kill encroaching leukemic cells without injuring normal ones. Computer programs have been written that incorporate rules of thumb as well as objective measures. The BIOMOD system can enter models in mathematical formats and can keep track of evolving output curves. The simulation can be stopped, changed, then proceed. Ultimately the models must incorporate a variety of information on blood and blood-forming tissue through the organized analysis of experimental and clinical data. Present efforts are aimed primarily at a teaching model. Each patient must now be considered as an average case of the teaching model. A patient-specific model will require that parameters be modified to account for individual biological differences. (To be presented at the Spring Joint Computer Conference, New Jersey, May 18, 1972.) 14 pp. Ref.

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Document Details

  • Copyright: RAND Corporation
  • Availability: Web Only
  • Year: 1972
  • Pages: 14
  • Document Number: P-4775

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Lincoln, Thomas L., The Clinical Significance of Simulation and Modeling in Leukemia Chemotherapy. Santa Monica, CA: RAND Corporation, 1972. https://www.rand.org/pubs/papers/P4775.html.
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