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The Structural Genomics Consortium

A knowledge platform for drug discovery

by Molly Morgan Jones, Sophie Castle-Clarke, Daniel Brooker, Edward Nason, Farah Huzair, Joanna Chataway

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The Structural Genomics Consortium (SGC) supports drug discovery efforts through a unique, open access model of public-private collaboration. This report presents the results of an independent evaluation of the Structural Genomics Consortium, conducted by RAND Europe with the Institute on Governance. The evaluation aimed to establish the role of the SGC within the wider drug discovery and public-private partnership (PPP) landscape, assessing the merits of the SGC open access model relative to alternative models of funding R&D in this space, as well as the key trends and opportunities in the external environment that may impact on the future of the SGC. It also established the incentives and disincentives for investment, strengths and weaknesses of the SGC's model, and the opportunities and threats the SGC will face in the future. This enabled us to assess the most convincing arguments for funding the SGC at present; important trade-offs or limitations that should be addressed in moving towards the next funding phase; and whether funders are anticipating changes either to the SGC or the wider PPP landscape. Finally, we undertook a quantitative analysis to ascertain what judgements can be made about the SGC's past and current performance track record, before unpacking the role of the external environment and particular actors within the SGC in developing scenarios for the future.

Table of Contents

  • Chapter One

    Introduction

  • Chapter Two

    The SGC in context: A review of relevant literature

  • Chapter Three

    The SGC as a model for investing in knowledge: Perspectives on the approach

  • Chapter Four

    The SGC as a model for generating knowledge: The model in practice

  • Chapter Five

    Extracting the value of knowledge: Outputs, outcomes and impacts of the SGC

  • Chapter Six

    Learning from the past to inform the future

  • Chapter Seven

    What comes next for the knowledge platform?

  • Appendix A

    Literature review material

  • Appendix B

    SGC Researcher Survey Analysis

  • Appendix C

    Methodology

Research conducted by

The research described in this report was prepared for and primarily funded by the Structural Genomics Consortium. It was also funded in part by the Policy Research Programme in the Department of Health. The research conducted by RAND Europe.

This report is part of the RAND Corporation Research report series. RAND reports present research findings and objective analysis that address the challenges facing the public and private sectors. All RAND reports undergo rigorous peer review to ensure high standards for research quality and objectivity.

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