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Genomic Medicine

Journal Article

B-cell Lymphoma and Non-Hodgkin's Lymphoma Treatment: How Do Participants of Chimeric Antigen Receptor T-cell (CAR-T) Therapy Research Studies Compare With Patients in the US Population?

Chimeric antigen receptor (CAR)-T-cell therapy appears to be a promising treatment for B-cell and non-Hodgkin's lymphoma. CAR-T therapy effectiveness in the general population of patients may differ from effectiveness demonstrated in trials.

Jun 17, 2021
Journal Article

An Evidence Map of Randomised Controlled Trials Evaluating Genetic Therapies

This evidence map provides a broad overview of the genetic therapies that have been evaluated in randomised controlled trials for efficacy and safety.

Mar 12, 2021
Report

What Is the Value of Invention?

Inventions help people around the world live longer, healthier, and more-productive lives. The inventions of Lemelson-MIT Prize winners illustrate the scientific, technological, economic, and social effects that inventions can have on society.

Feb 11, 2021
Journal Article

Global Public Perceptions of Genomic Data Sharing: What Shapes the Willingness to Donate DNA and Health Data?

Analyzing genomic data across populations is central to understanding the role of genetic factors in health and disease. This paper presents results from a very large public survey on attitudes toward genomic data sharing.

Sep 22, 2020
Commentary

Ethics of Germline Editing Must Keep Up with Technology

Mainstream interest in genome editing is now surging. If this research is to go forward, the science should be well understood by those conducting the research. Best practices and the highest scientific standards should be employed to limit risks and prevent unintended consequences.

Jan 10, 2019
Report

Best Practices for Participant and Stakeholder Engagement in the All of Us Research Program

RAND researchers identified best practices for engaging participants in the All of Us Research Program, which collects long-term health data from 1 million U.S. adults. Engagement involves awareness, enrollment, and retention of program participants.

Aug 17, 2018
Journal Article

Genome-Wide Scan of Depressive Symptomatology in Two Representative Cohorts in the United States and the United Kingdom

This exploration of genomic associations with depression found no compelling evidence of a single genetic variant's significant role in depressive symptomatology.

Apr 17, 2018
Journal Article

Medical Oncologists' Experiences in Using Genomic Testing for Lung and Colorectal Cancer Care

More research is needed to determine whether the observed variation in genomic testing for lung and colorectal cancer reflects appropriate or inappropriate care.

Mar 13, 2017
Report

Population-scale sequencing and the future of genomic medicine: Learning from past and present efforts

This paper reflects on the variety and evolution of population-scale genome-sequencing initiatives, examining their diverse aims, activities, management and governance approaches, impacts, and policy and research implications.

Apr 29, 2016
Commentary

A New Model for Open Innovation: The Structural Genomics Consortium

Open innovation is often suggested as a solution to enhance productivity in under-performing areas of research. Now, the strengths and weaknesses of a new open innovation model in drug discovery have been evaluated.

Mar 25, 2014
News Release

The Structural Genomics Consortium, an Innovative Open-Access, Public–Private Partnership, Is a Viable Model for Drug ...

The Structural Genomics Consortium is a viable model for drug discovery that appeals to investors, not least for advantages in efficiency over current models of public or commercial health research.

Mar 10, 2014
Report

Structural Genomics Consortium Offers Knowledge Platform for Drug Discovery

An independent evaluation of the Structural Genomics Consortium (SGC) examined the strengths and weaknesses of its efforts to support drug discovery efforts through a unique, open access model of public-private collaboration.

Mar 10, 2014
Report

The Structural Genomics Consortium: A knowledge platform for drug discovery: A summary

This report summarises the results of an independent evaluation of the Structural Genomics Consortium, an open access model of public-private collaboration, conducted by RAND Europe with the Institute on Governance.

Mar 10, 2014
Journal Article

The Value of Diagnostic Testing in Personalized Medicine

A framework derived from information economics for assessing the value of diagnostics demonstrates that the social value of such diagnostics can be very large, both by avoiding unnecessary treatment and by identifying patients who otherwise would not get treated.

Jun 1, 2013
Journal Article

Effective Communication of Molecular Genetic Test Results

Using a template for molecular genetic test reports, developed to reduce communication errors between the laboratory and ordering clinician, was found to improve physician ratings compared to standard laboratory templates—especially with doctors who were least familiar with the reports.

Dec 6, 2012
Commentary

What Will Change Most About Our Routine Physicals Over the Next Decade?

Don't forget—an American's odds of living a long and healthy life still depend more on his zip code than his genetic code. That won't change until we make healthcare more affordable, writes Dr. Arthur Kellermann.

Aug 31, 2012
Journal Article

A Report Template for Molecular Genetic Tests Designed to Improve Communication Between the Clinician and Laboratory

With input from key stakeholders and building upon prior work, we created a template for molecular genetic test reports designed to improve clinical decision making at the point of care.

Jul 16, 2012
Journal Article

Diagnostics as Essential Tools for Containing Antibacterial Resistance

Appropriate use of existing diagnostic tests for infections, and development of better ones, could reduce overuse of antibacterial drugs.

Apr 1, 2011
Journal Article

Population Prevalence of Familial Cancer and Common Hereditary Cancer Syndromes: The 2005 California Health Interview Survey

We provide population-based prevalence estimates for moderate and strong familial risk for five common cancers and hereditary breast-ovarian cancer and hereditary nonpolyposis colon cancer.

Nov 1, 2010
Journal Article

Are Electronic Health Records Ready for Genomic Medicine?

The goal of this project was to assess genetic/genomic content in electronic health records.

Jul 1, 2009

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RAND Topic:
Genomic Medicine

Topic Synonyms:
Genomics