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Genetics

Recent breakthroughs in genetics have the potential to significantly improve health outcomes. RAND research examines the impact of genetics on personal and public health, disease prevention, diagnosis, and treatment.

Journal Article

B-cell Lymphoma and Non-Hodgkin's Lymphoma Treatment: How Do Participants of Chimeric Antigen Receptor T-cell (CAR-T) Therapy Research Studies Compare With Patients in the US Population?

Chimeric antigen receptor (CAR)-T-cell therapy appears to be a promising treatment for B-cell and non-Hodgkin's lymphoma. CAR-T therapy effectiveness in the general population of patients may differ from effectiveness demonstrated in trials.

Jun 17, 2021
Journal Article

An Evidence Map of Randomised Controlled Trials Evaluating Genetic Therapies

This evidence map provides a broad overview of the genetic therapies that have been evaluated in randomised controlled trials for efficacy and safety.

Mar 12, 2021
Report

What Is the Value of Invention?

Inventions help people around the world live longer, healthier, and more-productive lives. The inventions of Lemelson-MIT Prize winners illustrate the scientific, technological, economic, and social effects that inventions can have on society.

Feb 10, 2021
Report

Wellcome Sanger Institute and Wellcome Genome Campus Landscape Review

RAND Europe was commissioned by Wellcome to analyse the role and contribution of the Sanger Institute and the Wellcome Genome Campus within the field of genetics and genomics, set within the context of four comparator organisations.

Jan 19, 2021
Journal Article

Global Public Perceptions of Genomic Data Sharing: What Shapes the Willingness to Donate DNA and Health Data?

Analyzing genomic data across populations is central to understanding the role of genetic factors in health and disease. This paper presents results from a very large public survey on attitudes toward genomic data sharing.

Sep 22, 2020
Journal Article

Trust in Genomic Data Sharing Among Members of the General Public in the UK, USA, Canada and Australia

Trust may be important in shaping public attitudes to genetics and intentions to participate in genomics research and big data initiatives. This study examined trust in data sharing among the general public in the USA, Canada, UK and Australia.

Oct 10, 2019
Tool

Forensic DNA Surveillance Tool

This tool shows criminal justice policymakers how state policies affect the size and racial composition of forensic DNA databases. Users can view current state policies or change inputs and assumptions to see how database composition is impacted.

Aug 12, 2019
Report

Forensic Familial and Moderate Stringency DNA Searches: Policies and Practices in the United States, England, and Wales

Forensic DNA databases help solve crimes. When an exact DNA match is not found, familial DNA and moderate stringency search may provide investigative leads. Evidence-based practices can guide policymakers on the use and effectiveness of this method.

Aug 12, 2019
Commentary

Ethics of Germline Editing Must Keep Up with Technology

Mainstream interest in genome editing is now surging. If this research is to go forward, the science should be well understood by those conducting the research. Best practices and the highest scientific standards should be employed to limit risks and prevent unintended consequences.

Jan 10, 2019
Report

Best Practices for Participant and Stakeholder Engagement in the All of Us Research Program

RAND researchers identified best practices for engaging participants in the All of Us Research Program, which collects long-term health data from 1 million U.S. adults. Engagement involves awareness, enrollment, and retention of program participants.

Aug 17, 2018
Journal Article

Genome-Wide Scan of Depressive Symptomatology in Two Representative Cohorts in the United States and the United Kingdom

This exploration of genomic associations with depression found no compelling evidence of a single genetic variant's significant role in depressive symptomatology.

Apr 17, 2018
Journal Article

BMI Loci and Longitudinal BMI from Adolescence to Young Adulthood in an Ethnically Diverse Cohort

Several established BMI genetic variants are positively associated with change in BMI during the period of adolescence and young adulthood.

Mar 14, 2017
Journal Article

Medical Oncologists' Experiences in Using Genomic Testing for Lung and Colorectal Cancer Care

More research is needed to determine whether the observed variation in genomic testing for lung and colorectal cancer reflects appropriate or inappropriate care.

Mar 13, 2017
Journal Article

The Interaction Between Physical Activity and Obesity Gene Variants in Association with BMI: Does the Obesogenic Environment Matter?

This study of a diverse sample of American adolescents found that neighborhood environmental factors did not appear to influence genetic obesity risk.

Nov 15, 2016
Journal Article

Evidence for Association Between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study

In young adults with European heritage, a blood marker used to classify type 2 diabetes, HbA1c, was found to be significantly associated with two variants of a genetic region involved in metabolic control, SH2B1.

Sep 29, 2016
Report

Population-scale sequencing and the future of genomic medicine: Learning from past and present efforts

This paper reflects on the variety and evolution of population-scale genome-sequencing initiatives, examining their diverse aims, activities, management and governance approaches, impacts, and policy and research implications.

Apr 29, 2016
Journal Article

Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-Httlpr) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older

Depending on genetic sensitivity to it, stress may affect depressive symptomatology differentially.

Feb 29, 2016
Journal Article

OXTR Polymorphism Predicts Social Relationships Through Its Effects on Social Temperament

Humans have a fundamental need for strong interpersonal bonds, yet individuals differ appreciably in their degree of social integration.

Jan 12, 2015
Multimedia

Cognitive Aging, Neuropathology, and Resilience

Session from the 21st Annual RAND Summer Institute, held July 7-11, 2014, in Santa Monica, CA, addressing critical issues facing our aging population.

Sep 8, 2014
Commentary

A New Model for Open Innovation: The Structural Genomics Consortium

Open innovation is often suggested as a solution to enhance productivity in under-performing areas of research. Now, the strengths and weaknesses of a new open innovation model in drug discovery have been evaluated.

Mar 25, 2014

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