Recent breakthroughs in genetics have the potential to significantly improve health outcomes. RAND research examines the impact of genetics on personal and public health, disease prevention, diagnosis, and treatment.
Human performance enhancement (HPE) will have implications for military and intelligence operations. A variety of HPE could be of potential military and intelligence operational value. What are some approaches to HPE?
Chimeric antigen receptor (CAR)-T-cell therapy appears to be a promising treatment for B-cell and non-Hodgkin's lymphoma. CAR-T therapy effectiveness in the general population of patients may differ from effectiveness demonstrated in trials.
Inventions help people around the world live longer, healthier, and more-productive lives. The inventions of Lemelson-MIT Prize winners illustrate the scientific, technological, economic, and social effects that inventions can have on society.
RAND Europe was commissioned by Wellcome to analyse the role and contribution of the Sanger Institute and the Wellcome Genome Campus within the field of genetics and genomics, set within the context of four comparator organisations.
Analyzing genomic data across populations is central to understanding the role of genetic factors in health and disease. This paper presents results from a very large public survey on attitudes toward genomic data sharing.
Trust may be important in shaping public attitudes to genetics and intentions to participate in genomics research and big data initiatives. This study examined trust in data sharing among the general public in the USA, Canada, UK and Australia.
Forensic DNA databases help solve crimes. When an exact DNA match is not found, familial DNA and moderate stringency search may provide investigative leads. Evidence-based practices can guide policymakers on the use and effectiveness of this method.
This tool shows criminal justice policymakers how state policies affect the size and racial composition of forensic DNA databases. Users can view current state policies or change inputs and assumptions to see how database composition is impacted.
Mainstream interest in genome editing is now surging. If this research is to go forward, the science should be well understood by those conducting the research. Best practices and the highest scientific standards should be employed to limit risks and prevent unintended consequences.
RAND researchers identified best practices for engaging participants in the All of Us Research Program, which collects long-term health data from 1 million U.S. adults. Engagement involves awareness, enrollment, and retention of program participants.
In young adults with European heritage, a blood marker used to classify type 2 diabetes, HbA1c, was found to be significantly associated with two variants of a genetic region involved in metabolic control, SH2B1.
This paper reflects on the variety and evolution of population-scale genome-sequencing initiatives, examining their diverse aims, activities, management and governance approaches, impacts, and policy and research implications.