Three Essays on Hypertension Prevention and Medical Product Safety in China and the United States

by Ying Liu

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This dissertation addresses two important public health problems, namely hypertension prevention and medical product safety in China and the United States. The first essay employs PoPMoD, a life-table based disease model to analyze the long-term costs and effectiveness of eight selected hypertension prevention interventions in China. The results show that selected population-based interventions are more cost-effective than individual-based pharmaceutical therapies. The second essay explores the costs of medical product safety litigation in the U.S. — and thus incentives to invest in product safety — by modeling and estimating changes in the market values of pharmaceutical firms involved in ongoing medical mass torts. The third essay reviews recent changes and remaining problems in China’s drug safety regulation since the occurrence of several high-profile, deadly incidents during 2006-2008.

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This document was submitted as a dissertation in December 2009 in partial fulfillment of the requirements of the doctoral degree in public policy analysis at the Pardee RAND Graduate School. The faculty committee that supervised and approved the dissertation consisted of Steve Garber (Chair), John Graham, and Wei Zhang.

This report is part of the RAND Corporation Dissertation series. Pardee RAND dissertations are produced by graduate fellows of the Pardee RAND Graduate School, the world's leading producer of Ph.D.'s in policy analysis. The dissertations are supervised, reviewed, and approved by a Pardee RAND faculty committee overseeing each dissertation.

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