Research Brief
Project Retrosight: Understanding the returns from cardiovascular and stroke research
Mar 6, 2011
Project Retrosight
Understanding the returns from cardiovascular and stroke research: Case Studies
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This project explores the impacts arising from cardiovascular and stroke research funded 15-20 years ago and attempts to draw out aspects of the research, researcher or environment that are associated with high or low impact. The project is a case study-based review of 29 cardiovascular and stroke research grants, funded in Australia, Canada and UK between 1989 and 1993. The case studies focused on the individual grants but considered the development of the investigators and ideas involved in the research projects from initiation to the present day. Grants were selected through a stratified random selection approach that aimed to include both high- and low-impact grants. The key messages are as follows: 1) The cases reveal that a large and diverse range of impacts arose from the 29 grants studied. 2) There are variations between the impacts derived from basic biomedical and clinical research. 3) There is no correlation between knowledge production and wider impacts 4) The majority of economic impacts identified come from a minority of projects. 5) This report identified factors that appear to be associated with high and low impact. This report presents the full set of case studies.
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Table of Contents
Chapter One
To conduct studies of a high density lipoprotein conversion factor
Chapter Two
Fibrillin deficiency in Marfan syndrome and overlapping syndromes (familial mitral valve prolapse, familial ascending aortic aneurysm): diagnosis and risk stratification
Chapter Three
'Heartstart Scotland' – analysis of the results of a national programme
Chapter Four
Haemostatic markers in acute transient ischaemic attacks
Chapter Five
A follow-up study of heart attack patients
Chapter Six
Coronary lesions and vasoactivity
Chapter Seven
The organisation and nature of formed elements within the paracellular clefts of capillary endothelia
Chapter Eight
Low-intensity warfarin and thrombosis
Chapter Nine
Analysis of the glucose transporter compliment and function in metabolically important tissues of the Milan hypertensive rat
Chapter Ten
The role of coagulation and fibrinolysis in the pathogenesis of recurrent stroke
Chapter Eleven
Nimodipine binding in cerebral ischaemia
Chapter Twelve
Genetic and cellular determinants of increased growth of vascular smooth muscle in spontaneously hypertensive rats
Chapter Thirteen
The study of the role of the regulatory gene, Mlx1, in cardiac development and disease, and the creation of animal models for myocardial dysfunction
Chapter Fourteen
Effect of simulated stroke on developing astrocytes
Chapter Fifteen
The effects of alcohol consumption on blood pressure, plasma lipoprotein cholesterol fractions and sympathetic nervous system function in man
Chapter Sixteen
Electrophysiologic properties of cardiac myocytes in cardiomyopathy
Chapter Seventeen
To study the effects of angiotensin-converting enzyme inhibitors on tissue and cardiac angiotensin-converting enzyme
Chapter Eighteen
Vasoactive substances and pathogenesis of essential hypertension
Chapter Nineteen
Immunoelectron microscopy of amine and peptide synapses on sympathetic preganglionic neurons
Chapter Twenty
Right-hemisphere stroke: incidence, severity and recovery of language disorders
Chapter Twenty-One
To study secondary prevention of hypertension
Chapter Twenty-Two
The effects of lean meat diets on plasma lipids and haemostatic functions
Chapter Twenty-Three
Cell–cell interactions in the disposition of natriuretic peptides in the bovine chromaffin cells
Chapter Twenty-Four
Is hepatic synthesis and secretion of lecithin-cholesterol acyltransferase (LCAT) linked to lipoprotein production by the liver and intestine?
Chapter Twenty-Five
Modulation of nitric oxide biosynthesis by polyamines
Chapter Twenty-Six
Antiarrhythmic drug receptor
Chapter Twenty-Seven
Biobehavioural influences on hypertension and atherosclerosis
Chapter Twenty-Eight
Prolonged heart and lung allograft preservation
Chapter Twenty-Nine
Stroke prevention in the elderly in primary care
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