Prioritizing Feasible and Impactful Actions to Enable Secure Artificial Intelligence Development and Use in Biology

Josh Dettman, Emily Lathrop, Aurelia Attal-Juncqua, Matthew L. Nicotra, Allison Berke

Published Sep 25, 2025

Although significant work has been done to evaluate general-purpose artificial intelligence (AI) and specialized biological design tools for biothreat creation risks, actionable steps to mitigate the risk of AI-enabled biothreat creation are underdeveloped.

In this paper, the authors provide policy and technology strategies in an organizing framework and prioritize the development of seven mitigation strategies.

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Dettman, Josh, Emily Lathrop, Aurelia Attal-Juncqua, Matthew L. Nicotra, and Allison Berke, Prioritizing Feasible and Impactful Actions to Enable Secure Artificial Intelligence Development and Use in Biology. Santa Monica, CA: RAND Corporation, 2025. https://www.rand.org/pubs/working_papers/WRA4213-1.html.
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