Using health status measures adapted from the MOS scale and contained in the HIV-PARSE survey instrument, RAND developed a perceived health index for people with advanced HIV disease. The scale was demonstrated to be a reliable and valid means of summarizing self-reported current health, correlating strongly with clinical indicators. Conclusions were based on data from approximately 2,000 clinical trial participants (over 7,000 observations). The mean CD4 count was 131. Measures of internal consistency ranged from 0.86-0.90, and items demonstrated excellent discrimination across scales. The reliability in the index was estimated to be 0.94. The Perceived Health Index should be a useful outcome measure for patients enrolling in clinical trials of therapies for advanced HIV disease.
This report is part of the RAND Corporation External publication series. Many RAND studies are published in peer-reviewed scholarly journals, as chapters in commercial books, or as documents published by other organizations.
Our mission to help improve policy and decisionmaking through research and analysis is enabled through our core values of quality and objectivity and our unwavering commitment to the highest level of integrity and ethical behavior. To help ensure our research and analysis are rigorous, objective, and nonpartisan, we subject our research publications to a robust and exacting quality-assurance process; avoid both the appearance and reality of financial and other conflicts of interest through staff training, project screening, and a policy of mandatory disclosure; and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. For more information, visit www.rand.org/about/research-integrity.
The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.