Cover: Association of Pregnancy and Insurance Status With Treatment Access for Opioid Use Disorder

Association of Pregnancy and Insurance Status With Treatment Access for Opioid Use Disorder

Published in: JAMA Network Open, Volume 3, Issue 8 (2020). doi: 10.1001/jamanetworkopen.2020.13456

Posted on Sep 3, 2020

by Stephen W. Patrick, Michael R. Richards, William D. Dupont, Elizabeth McNeer, Melinda Beeuwkes Buntin, Peter R. Martin, Matthew A. Davis, Corey S. Davis, Katherine E. Hartmann, Ashley A. Leech, et al.

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Medications for opioid use disorder, including buprenorphine hydrochloride and methadone hydrochloride, are highly effective at improving outcomes for individuals with the disorder. For pregnant women, use of these medications also improves pregnancy outcomes, including the risk of preterm birth. Despite the known benefits of medications for opioid use disorder, many pregnant and nonpregnant women with the disorder are not receiving them.


To determine whether pregnancy and insurance status are associated with a woman's ability to obtain an appointment with an opioid use disorder treatment clinician.

Design, Setting, and Participants

In this cross-sectional study with random assignment of clinicians and simulated-patient callers (performed in "secret shopper" format), outpatient clinics that provide buprenorphine and methadone were randomly selected from publicly available treatment lists in 10 US states (selected for variability in opioid-related outcomes and policies) from March 7 to September 5, 2019. Pregnant vs nonpregnant woman and private vs public insurance assigned randomly to callers to create unique patient profiles. Simulated patients called the clinics posing as pregnant or nonpregnant women to obtain an initial appointment with a clinician.

Main Outcomes and Measures

Appointment scheduling, wait time, and out-of-pocket costs.


A total of 10,871 unique patient profiles were assigned to 6324 clinicians. Among all women, 2312 of 3420 (67.6%) received an appointment with a clinician who prescribed buprenorphine, with lower rates among pregnant vs nonpregnant callers (1055 of 1718 [61.4%] vs 1257 of 1702 [73.9%]; relative risk, 0.83; 95% CI, 0.79–0.87). For clinicians who prescribed methadone, there was no difference in appointment access for pregnant vs nonpregnant callers (240 of 271 [88.6%] vs 237 of 265 [89.4%]; relative risk, 0.99; 95% CI, 0.93–1.05). Insurance was frequently not accepted, with 894 of 3420 buprenorphine-waivered prescribers (26.1%) and 174 of 536 opioid treatment programs (32.5%) granting appointments only when patients agreed to pay cash. Median wait times did not differ between pregnant and nonpregnant callers among buprenorphine prescribers (3 days [interquartile range, 1–7 days] vs 3 days [interquartile range, 1–7 days]; P = .43) but did differ among methadone prescribers (1 day [interquartile range, 1–4 days] vs 2 days [interquartile range, 1–6 days]; P = .049). For patients agreeing to pay cash, the median out-of-pocket costs for initial appointments were $250 (interquartile range, $155–$300) at buprenorphine prescribers and $34 (interquartile range, $15–$120) at methadone prescribers.

Conclusions and Relevance

In this cross-sectional study with random assignment of clinicians and simulated-patient callers, many women, especially pregnant women, faced barriers to accessing treatment. Given the high out-of-pocket costs and lack of acceptance of insurance among many clinicians, access to affordable opioid use disorder treatment is a significant concern.

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