Protecting the Most Vulnerable by Vaccinating the Most Active
Download Free Electronic Document
|PDF file||0.2 MB||
Use Adobe Acrobat Reader version 10 or higher for the best experience.
In this Perspective, the authors used a network simulation model to illustrate five different vaccination strategies for coronavirus disease 2019 (COVID-19), showing that vaccinating the most-active members of the population might be the best way to save lives overall and still protect the vulnerable.
Recent models of COVID-19 vaccination have tended not to take into account the person-to-person contact structure that results in the disease's spread. The authors used a model based on a realistic contact network (derived from a data set of 2.2 billion mobile device location points) to run five different vaccination models. What varied between each case was the number of contacts of the people who were vaccinated. The base case assumes no vaccination; the low-contact model vaccinates those with the fewest contacts (corresponding to those already identified as high risk who are able to limit contacts); the uniform model vaccinates 15 percent of the population at random; and the final two models vaccinate those with the most contacts—the high-contact model vaccinates the 15 percent of people with the most contacts, and the high-contact imperfect model vaccinates one-half of the 30 percent of people with the most contacts.
The authors found that the high-contact imperfect strategy is at least as effective (and probably more effective) at protecting the vulnerable than direct vaccination and indicates that the United States might be able to provide more protection for vulnerable people by vaccinating people with many contacts than by vaccinating vulnerable people directly.
Research conducted by
Funding for this Perspective was provided by gifts from RAND supporters and income from operations. This research was conducted in the Community Health and Environmental Policy Program within RAND Social and Economic Well-Being.
This publication is part of the RAND Corporation Perspective series. RAND Perspectives present expert insights on timely policy issues. All RAND Perspectives undergo peer review to ensure high standards for quality and objectivity.
This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited; linking directly to this product page is encouraged. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial purposes. For information on reprint and reuse permissions, please visit www.rand.org/pubs/permissions.
The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. RAND's publications do not necessarily reflect the opinions of its research clients and sponsors.