Anna Jean Wirth

Associate Physical Scientist
Pittsburgh Office


Ph.D. in chemistry, University of Illinois at Urbana-Champaign; B.S. in chemistry, College of William and Mary


Anna Jean Wirth is an associate physical scientist at the RAND Corporation. For her graduate thesis work she studied protein dynamics, a multi-disciplinary field encompassing chemistry, biology, and physics. Her most recent work sought to bridge the gap between experiment and simulation of biomolecule dynamics. Her research interests fall in the realms of national security, science and technology policy, and K-12 science education policy. Wirth received her B.S. in chemistry from the College of William and Mary and her Ph.D. in chemistry from the University of Illinois at Urbana-Champaign.

Selected Publications

Wirth, A., Liu, Y., Prigozhin, M., Schulten, K., Gruebele, M., "Comparing fast pressure jump and temperature jump protein folding experiments and simulations," Journal of the American Chemical Society, 137(22):7152-7159, 2015

Wirth, A., Gruebele, M., "Leaving the test-tube behind: Quinary protein structure and the consequences of crowding in living cells," BioEssays, 35(11):984-993, 2013

Wirth, A., Platkov, M., Gruebele, M., "Temporal variation of a protein folding energy landscape in the cell," Journal of the American Chemical Society, 135(51):19215-19221, 2013