A Review of the Scientific Literature as it Pertains to Gulf War Illnesses

Volume 8: Pesticides

by Gary Cecchine, Beatrice A. Golomb, Lee H. Hilborne, Dalia M. Spektor, C. Ross Anthony

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This report summarizes the scientific literature on 12 of the 35 pesticides that are likely to have been used during the Persian Gulf War. Where possible, it focuses on known pesticide exposures or doses and related health outcomes that may be relevant to symptoms reported by some Gulf War veterans. Particular attention is paid to long-term, chronic effects of reported exposures to organophosphate and carbamate pesticides. Evidence from epidemiological studies, studies of genetic and biological differences between ill and healthy subjects, and studies of the physiological mechanisms of organophosphate and carbamate pesticides is suggestive, but not conclusive, that these pesticides could be among the potential contributing agents to some of the undiagnosed illnesses seen in Gulf War veterans. However, no prospective studies have been conducted that positively identify pesticides as causative agents. More research is needed to confirm or refute a causal link between pesticides and other agents and the symptoms associated with Gulf War illnesses.

Table of Contents

  • Preface

  • Figures

  • Tables

  • Summary

  • Acknowledgments

  • Acronyms and Abbreviations

  • Chapter One

    Introduction

  • Chapter Two

    Pesticides

  • Chapter Three

    Health Problems in PGWV

  • Chapter Four

    Lindane

  • Chapter Five

    DEET

  • Chapter Six

    Pyrethroids

  • Chapter Seven

    Organophosphates and Carbamates

  • Chapter Eight

    Confounding Factors: Individual Differences and Interactions

  • Chapter Nine

    Concluding Remarks

  • Appendix

    Comparison by Symptom Category of Subjects with AChE-Inhibitor Exposure (Organophosphate or Carbamate) and Ill PGWV

  • Bibliography

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This research was sponsored by the RAND National Security Research Division and RAND Health.

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